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Clocks & Sleep, Volume 2, Issue 3 (September 2020) – 10 articles

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9 pages, 262 KiB  
Article
Nightmares, Chronotype, Urbanicity, and Personality: An Online Study
by Michael Schredl and Anja S. Göritz
Clocks & Sleep 2020, 2(3), 390-398; https://doi.org/10.3390/clockssleep2030029 - 22 Sep 2020
Cited by 2 | Viewed by 3227
Abstract
Chronotype refers to individual differences in sleep timing (“owls” and “larks”) and “eveningness” has been associated with nightmares. However, it has not been tested as to whether neuroticism mediates this relationship. Urbanicity refers to being raised in an urban region and/or currently living [...] Read more.
Chronotype refers to individual differences in sleep timing (“owls” and “larks”) and “eveningness” has been associated with nightmares. However, it has not been tested as to whether neuroticism mediates this relationship. Urbanicity refers to being raised in an urban region and/or currently living in an urban region and is associated with heightened risk for developing mental disorders, and thus might be related to nightmare frequency and nightmare distress. Overall, 2492 persons (1437 women, 1055 men) completed an online survey between 23 March 2015 and 8 April 2015. The mean age of the sample was 47.75 ± 14.41 years. The findings indicate that the previously reported relationship between chronotype and nightmare frequency was mediated by neuroticism and “morningness” was related to higher dream recall compared to persons with a late bedtime preference. Urbanicity was not related to nightmare frequency but to lower nightmare distress, raising the interesting question as to whether beliefs about nightmares might be an important variable that contributes to nightmare distress. Based on the few studies so far, there are still many unresolved questions about the interaction between nightmares, chronotype, and urbanicity. Full article
(This article belongs to the Section Disorders)
15 pages, 1925 KiB  
Article
The Parent’s Chronotype and Child’s Sleeping Quality in Association with Relationship Satisfaction
by Cristian Ricci, Zaida Parra-Robledo, Dietrich Rothenbacher, Juan Francisco Díaz-Morales and Jon Genuneit
Clocks & Sleep 2020, 2(3), 375-389; https://doi.org/10.3390/clockssleep2030028 - 18 Sep 2020
Cited by 3 | Viewed by 2865
Abstract
The prospective Ulm-SPATZ study was investigated to assess the role of child sleeping quality between 4 to 6 years of age in affecting a partner’s sleeping and relationship satisfaction within a couple. The study was conducted using a triadic approach in which the [...] Read more.
The prospective Ulm-SPATZ study was investigated to assess the role of child sleeping quality between 4 to 6 years of age in affecting a partner’s sleeping and relationship satisfaction within a couple. The study was conducted using a triadic approach in which the child was included in the Actor-Partner-Interdependence Model (APIM). Sleeping quality of the child was determined by using the German version of the children’s sleep habits questionnaire, sleeping features of the parents were assessed by using the Munich chronotype questionnaire, and the partner relationship assessment was performed by employing the German version of the parenting stress index questionnaire. In 211 German triads, we observed that sleeping characteristics and partner relationship scores at different child ages are consistent for both men and women. Higher and statistically significant sleep duration, time spent in bed, the midpoint of sleep, time getting out of bed, and sleep onset in women compared to men during the working days were observed. The APIM analyses showed a significant direct effect of child sleep quality on the partner relationship satisfaction. In women, a mediated effect of child sleep quality acted through sleep duration and time spent in bed on the partner relationship satisfaction score during both free and working days. In men, low child sleep quality was found to be associated with increased sleep onset during both free and working days. Child sleep quality influences relationship satisfaction mostly in mothers, likely because of their higher involvement in childcare during working days. Distress in the couple could be counteracted by a major involvement of the fathers in child management. Full article
(This article belongs to the Section Society)
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11 pages, 2361 KiB  
Article
Validation of Oximetry for Diagnosing Obstructive Sleep Apnea in a Clinical Setting
by Kazuki Ito, Masahiro Uetsu and Hiroshi Kadotani
Clocks & Sleep 2020, 2(3), 364-374; https://doi.org/10.3390/clockssleep2030027 - 29 Aug 2020
Cited by 5 | Viewed by 3615
Abstract
A large epidemiological study using oximetry to analyze obstructive sleep apnea (OSA) and metabolic comorbidities was performed in Japan; however, reliability and validity of oximetry in the Japanese population remains poorly understood. In this study, oximetry data from the epidemiological study were compared [...] Read more.
A large epidemiological study using oximetry to analyze obstructive sleep apnea (OSA) and metabolic comorbidities was performed in Japan; however, reliability and validity of oximetry in the Japanese population remains poorly understood. In this study, oximetry data from the epidemiological study were compared with data from clinically performed polysomnography (PSG) and out-of-center sleep testing (OCST) in epidemiological study participants who later attended our outpatient units. The oxygen desaturation index (ODI) from oximetry showed a moderate positive relationship (correlation coefficient r = 0.561, p < 0.001) with apnea/hypopnea data from PSG/OCST. The area under the receiver operating characteristic curve showed moderate accuracy of this method in the detection of moderate-to-severe or severe OSA. However, the optimal ODI thresholds to detect moderate-to-severe OSA and severe OSA were the same (ODI > 20.1). Oximetry may be a useful tool for screening moderate-to-severe or severe sleep apnea. However, it may be difficult to set an appropriate threshold to distinguish between moderate and severe sleep apnea by oximetry alone. Full article
(This article belongs to the Section Disorders)
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10 pages, 420 KiB  
Article
Mindfulness and Smartphone Addiction before Going to Sleep among College Students: The Mediating Roles of Self-Control and Rumination
by Shi-Shi Cheng, Chun-Qing Zhang and Jiang-Qiu Wu
Clocks & Sleep 2020, 2(3), 354-363; https://doi.org/10.3390/clockssleep2030026 - 29 Aug 2020
Cited by 16 | Viewed by 5243
Abstract
This study aims to examine the effects among college students of mindfulness on smartphone addiction before going to bed at night. We examined the mediating roles of self-control and rumination on the mindfulness–smartphone addiction path. Participants (n = 270, 59.3% females, 18–24 [...] Read more.
This study aims to examine the effects among college students of mindfulness on smartphone addiction before going to bed at night. We examined the mediating roles of self-control and rumination on the mindfulness–smartphone addiction path. Participants (n = 270, 59.3% females, 18–24 years old) completed self-reporting questionnaires measuring mindfulness, self-control, smartphone addiction, and rumination. In addition to the correlation analysis, we adopted a stepwise regression analysis with bootstrapping to test the mediating effects. It was found that mindfulness was inversely related to smartphone addiction before going to sleep. Most importantly, self-control and rumination significantly mediated the effects of mindfulness on smartphone addiction among college students. The findings of this study indicated that mindfulness training is beneficial to improve the ability of self-control and reduce rumination levels, thereby inhibiting the negative impact of smartphone addiction on college students before they go to sleep, and further promoting their sleep health and mental health. Full article
(This article belongs to the Section Human Basic Research & Neuroimaging)
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20 pages, 537 KiB  
Article
Increased Resilience Weakens the Relationship between Perceived Stress and Anxiety on Sleep Quality: A Moderated Mediation Analysis of Higher Education Students from 7 Countries
by Chen Du, Megan Chong Hueh Zan, Min Jung Cho, Jenifer I. Fenton, Pao Ying Hsiao, Richard Hsiao, Laura Keaver, Chang-Chi Lai, HeeSoon Lee, Mary-Jon Ludy, Wan Shen, Winnie Chee Siew Swee, Jyothi Thrivikraman, Kuo-Wei Tseng, Wei-Chin Tseng and Robin M. Tucker
Clocks & Sleep 2020, 2(3), 334-353; https://doi.org/10.3390/clockssleep2030025 - 11 Aug 2020
Cited by 47 | Viewed by 11065
Abstract
High levels of perceived stress and anxiety among university students are a global concern and are known to negatively influence sleep. However, few studies have explored how stress response styles, like psychological resilience and rumination, might alter these relationships. Using validated tools, perceived [...] Read more.
High levels of perceived stress and anxiety among university students are a global concern and are known to negatively influence sleep. However, few studies have explored how stress response styles, like psychological resilience and rumination, might alter these relationships. Using validated tools, perceived stress, anxiety, stress response styles, and sleep behaviors of undergraduate and graduate students from seven countries during the height of the COVID-19 pandemic were characterized in order to examine the relationships between these factors using mediation and moderation analyses. Students enrolled in universities in China, Ireland, Malaysia, Taiwan, South Korea, the Netherlands, and the United States were recruited in May 2020. A total of 2254 students completed this cross-sectional study. Perceived stress and anxiety were negatively associated with sleep quality through the mediation of rumination. Increased psychological resilience weakened the relationships between perceived stress and anxiety on sleep quality. The majority of students reported that COVID-19 negatively influenced their mental health and sleep quality but not sleep duration. Based on these results, university students would likely benefit from sleep education and mental health promotion programs that include trainings to increase psychological resilience and reduce rumination, particularly during times of increased stress. Full article
(This article belongs to the Special Issue Sleep, Rhythms, and Mental Health)
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9 pages, 1137 KiB  
Article
Adverse Neurological Effects of Short-Term Sleep Deprivation in Aging Mice Are Prevented by SS31 Peptide
by Jinzi Wu, Yan Dou and Warren C. Ladiges
Clocks & Sleep 2020, 2(3), 325-333; https://doi.org/10.3390/clockssleep2030024 - 6 Aug 2020
Cited by 8 | Viewed by 4080
Abstract
Sleep deprivation is a potent stress factor that disrupts regulatory pathways in the brain resulting in cognitive dysfunction and increased risk of neurodegenerative disease with increasing age. Prevention of the adverse effects of sleep deprivation could be beneficial in older individuals by restoring [...] Read more.
Sleep deprivation is a potent stress factor that disrupts regulatory pathways in the brain resulting in cognitive dysfunction and increased risk of neurodegenerative disease with increasing age. Prevention of the adverse effects of sleep deprivation could be beneficial in older individuals by restoring healthy brain function. We report here on the ability of SS31, a mitochondrial specific peptide, to attenuate the negative neurological effects of short-term sleep deprivation in aging mice. C57BL/6 female mice, 20 months old, were subcutaneously injected with SS31 (3 mg/kg) or saline daily for four days. Sleep deprivation was 4 h daily for the last two days of SS31 treatment. Mice were immediately tested for learning ability followed by collection of brain and other tissues. In sleep deprived mice treated with SS31, learning impairment was prevented, brain mitochondrial ATP levels and synaptic plasticity regulatory proteins were restored, and reactive oxygen species (ROS) and inflammatory cytokines levels were decreased in the hippocampus. This observation suggests possible therapeutic benefits of SS31 for alleviating adverse neurological effects of short-term sleep loss. Full article
(This article belongs to the Section Animal Basic Research)
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17 pages, 4408 KiB  
Article
Sleep Network Deterioration as a Function of Dim-Light-At-Night Exposure Duration in a Mouse Model
by Maria Panagiotou, Jos H.T. Rohling and Tom Deboer
Clocks & Sleep 2020, 2(3), 308-324; https://doi.org/10.3390/clockssleep2030023 - 23 Jul 2020
Cited by 4 | Viewed by 3543
Abstract
Artificial light, despite its widespread and valuable use, has been associated with deterioration of health and well-being, including altered circadian timing and sleep disturbances, particularly in nocturnal exposure. Recent findings from our lab reveal significant sleep and sleep electroencephalogram (EEG) changes owing to [...] Read more.
Artificial light, despite its widespread and valuable use, has been associated with deterioration of health and well-being, including altered circadian timing and sleep disturbances, particularly in nocturnal exposure. Recent findings from our lab reveal significant sleep and sleep electroencephalogram (EEG) changes owing to three months exposure to dim-light-at-night (DLAN). Aiming to further explore the detrimental effects of DLAN exposure, in the present study, we continuously recorded sleep EEG and the electromyogram for baseline 24-h and following 6-h sleep deprivation in a varied DLAN duration scheme. C57BL/6J mice were exposed to a 12:12 h light:DLAN cycle (75lux:5lux) vs. a 12:12 h light:dark cycle (75lux:0lux) for one day, one week, and one month. Our results show that sleep was already affected by a mere day of DLAN exposure with additional complications emerging with increasing DLAN exposure duration, such as the gradual delay of the daily 24-h vigilance state rhythms. We conducted detrended fluctuation analysis (DFA) on the locomotor activity data following 1-month and 3-month DLAN exposure, and a significantly less healthy rest-activity pattern, based on the decreased alpha values, was found in both conditions compared to the control light-dark. Taking into account the behavioral, sleep and the sleep EEG parameters, our data suggest that DLAN exposure, even in the shortest duration, induces deleterious effects; nevertheless, potential compensatory mechanisms render the organism partly adjustable and able to cope. We think that, for this reason, our data do not always depict linear divergence among groups, as compared with control conditions. Chronic DLAN exposure impacts the sleep regulatory system, but also brain integrity, diminishing its adaptability and reactivity, especially apparent in the sleep EEG alterations and particular low alpha values following DFA. Full article
(This article belongs to the Section Impact of Light & other Zeitgebers)
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26 pages, 1165 KiB  
Review
MicroRNA: A Key Player for the Interplay of Circadian Rhythm Abnormalities, Sleep Disorders and Neurodegenerative Diseases
by Chisato Kinoshita, Yayoi Okamoto, Koji Aoyama and Toshio Nakaki
Clocks & Sleep 2020, 2(3), 282-307; https://doi.org/10.3390/clockssleep2030022 - 23 Jul 2020
Cited by 29 | Viewed by 6674
Abstract
Circadian rhythms are endogenous 24-h oscillators that regulate the sleep/wake cycles and the timing of biological systems to optimize physiology and behavior for the environmental day/night cycles. The systems are basically generated by transcription–translation feedback loops combined with post-transcriptional and post-translational modification. Recently, [...] Read more.
Circadian rhythms are endogenous 24-h oscillators that regulate the sleep/wake cycles and the timing of biological systems to optimize physiology and behavior for the environmental day/night cycles. The systems are basically generated by transcription–translation feedback loops combined with post-transcriptional and post-translational modification. Recently, evidence is emerging that additional non-coding RNA-based mechanisms are also required to maintain proper clock function. MicroRNA is an especially important factor that plays critical roles in regulating circadian rhythm as well as many other physiological functions. Circadian misalignment not only disturbs the sleep/wake cycle and rhythmic physiological activity but also contributes to the development of various diseases, such as sleep disorders and neurodegenerative diseases. The patient with neurodegenerative diseases often experiences profound disruptions in their circadian rhythms and/or sleep/wake cycles. In addition, a growing body of recent evidence implicates sleep disorders as an early symptom of neurodegenerative diseases, and also suggests that abnormalities in the circadian system lead to the onset and expression of neurodegenerative diseases. The genetic mutations which cause the pathogenesis of familial neurodegenerative diseases have been well studied; however, with the exception of Huntington’s disease, the majority of neurodegenerative diseases are sporadic. Interestingly, the dysfunction of microRNA is increasingly recognized as a cause of sporadic neurodegenerative diseases through the deregulated genes related to the pathogenesis of neurodegenerative disease, some of which are the causative genes of familial neurodegenerative diseases. Here we review the interplay of circadian rhythm disruption, sleep disorders and neurodegenerative disease, and its relation to microRNA, a key regulator of cellular processes. Full article
(This article belongs to the Special Issue Crosstalk between Circadian Rhythm and Diseases)
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9 pages, 222 KiB  
Article
Work-Related Dreams: An Online Survey
by Michael Schredl, Lilian Marie Anderson, Lea Katharina Kahlert and Celine Sophie Kumpf
Clocks & Sleep 2020, 2(3), 273-281; https://doi.org/10.3390/clockssleep2030021 - 17 Jul 2020
Cited by 6 | Viewed by 3220
Abstract
Professional work is an integral part of modern life. According to the continuity hypothesis of dreaming, which states that dreams reflect waking life, work-related dreams should be quite common. As most dream content analytic studies are carried out in student samples, the topic [...] Read more.
Professional work is an integral part of modern life. According to the continuity hypothesis of dreaming, which states that dreams reflect waking life, work-related dreams should be quite common. As most dream content analytic studies are carried out in student samples, the topic of work in dreams is understudied. A few small studies indicate that the stress levels associated with the job are especially reflected in work-related dreams. Here, a total of 1695 people (960 women, 735 men) completed an online survey that included questions about the estimated percentage of work-related dreams, the overall emotional tone of work-related dreams, and waking-life experiences related to their current job situation (working or not working). The findings indicate that every fifth dream is related to current or previous work. Individuals who are working dreamed more often about work, with jobs that are experienced as being more stressful being more likely to affect dream content. The emotional tone of work-related dreams was related to stress and the emotions related to work in waking life. Overall, the findings demonstrate that professional life has a profound effect on dreaming in many individuals—even after years. The next steps would be to study the dream content of work-related dreams and relate these contents to specific characteristics about the jobs, e.g., professional field, hierarchical position and autonomy, etc. Full article
(This article belongs to the Section Disorders)
15 pages, 1728 KiB  
Article
Validation of an Automatic Arousal Detection Algorithm for Whole-Night Sleep EEG Recordings
by Daphne Chylinski, Franziska Rudzik, Dorothée Coppieters ‘t Wallant, Martin Grignard, Nora Vandeleene, Maxime Van Egroo, Laurie Thiesse, Stig Solbach, Pierre Maquet, Christophe Phillips, Gilles Vandewalle, Christian Cajochen and Vincenzo Muto
Clocks & Sleep 2020, 2(3), 258-272; https://doi.org/10.3390/clockssleep2030020 - 16 Jul 2020
Cited by 6 | Viewed by 3409
Abstract
Arousals during sleep are transient accelerations of the EEG signal, considered to reflect sleep perturbations associated with poorer sleep quality. They are typically detected by visual inspection, which is time consuming, subjective, and prevents good comparability across scorers, studies and research centres. We [...] Read more.
Arousals during sleep are transient accelerations of the EEG signal, considered to reflect sleep perturbations associated with poorer sleep quality. They are typically detected by visual inspection, which is time consuming, subjective, and prevents good comparability across scorers, studies and research centres. We developed a fully automatic algorithm which aims at detecting artefact and arousal events in whole-night EEG recordings, based on time-frequency analysis with adapted thresholds derived from individual data. We ran an automated detection of arousals over 35 sleep EEG recordings in healthy young and older individuals and compared it against human visual detection from two research centres with the aim to evaluate the algorithm performance. Comparison across human scorers revealed a high variability in the number of detected arousals, which was always lower than the number detected automatically. Despite indexing more events, automatic detection showed high agreement with human detection as reflected by its correlation with human raters and very good Cohen’s kappa values. Finally, the sex of participants and sleep stage did not influence performance, while age may impact automatic detection, depending on the human rater considered as gold standard. We propose our freely available algorithm as a reliable and time-sparing alternative to visual detection of arousals. Full article
(This article belongs to the Section Computational Models)
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