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Reports, Volume 7, Issue 2

June 2024 - 28 articles

Cover Story: This study estimated the prevalence of drug interactions with chloroquine (CQ) or hydroxychloroquine (HCQ) in COVID-19 inpatients during the pandemic waves and their association with hospitalization-related outcomes. In a sample of 487 patients with a mean age of 77.1 years (47.8% females), hospitalized for COVID-19 from March to December 2020, and treated with CQ or HCQ, we found that 255 (52.4%) had one drug interaction with CQ or HCQ, and 114 (23.4%) had ≥2 interactions. The most frequent drugs interacting with CQ or HCQ were lopinavir/ritonavir, azithromycin, tocilizumab, levofloxacin, clarithromycin, amlodipine, and trazodone. The presence of drug–drug interactions did not seem to impact the hospitalization duration and outcomes. View this paper
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Articles (28)

  • Case Report
  • Open Access
1 Citations
2,583 Views
5 Pages

Management of Pregnancy in a Patient with Familial Hypercholesterolemia and Previous Myocardial Infarction—Treatment with LDL Apheresis: A Case Report

  • Milos Milincic,
  • Jovana Todorovic,
  • Stefan Dugalic,
  • Ivana Novakovic,
  • Maja Macura,
  • Katarina Lalic and
  • Miroslava Gojnic Dugalic

Familial hypercholesterolemia, a genetic disorder marked by elevated low-density lipoprotein cholesterol (LDL-C), poses significant risks for premature atherosclerosis and cardiovascular diseases, particularly during pregnancy. One of the safe method...

  • Case Report
  • Open Access
2,929 Views
10 Pages

Cost-Effectiveness in Alternative Treatment Options for Pancreatic Pseudocysts

  • Nikola Boyanov,
  • Nikol Milinich,
  • Katina Shtereva,
  • Katerina Madzharova,
  • Stoilka Tufkova,
  • Mariana Penkova-Radicheva,
  • Daniela Radicheva and
  • Neno Shopov

Background and Objectives: Pancreatic pseudocysts often arise as complications of pancreatitis and present unique challenges in clinical management, encompassing considerations for both technical aspects and financial implications. Before the advance...

  • Article
  • Open Access
2,551 Views
10 Pages

Trophoblast Cell Surface Antigen 2 (Trop2) Is Expressed in Cases of EBV-Positive Diffuse Large B-Cell Lymphoma Emerging from Angioimmunoblastic T-Cell Lymphoma

  • Susanne Ghandili,
  • Judith Dierlamm,
  • Carsten Bokemeyer,
  • Clara Marie von Bargen,
  • Anne Menz and
  • Sören Alexander Weidemann

Although trophoblast cell surface antigen 2 (Trop2)-targeting drugs are already approved or under investigation in various solid tumors, the significance of Trop2 in lymphoma is unknown. Thus, our objective was to investigate the expression of Trop2...

  • Case Report
  • Open Access
17,128 Views
5 Pages

Gardasil 4, a human papilloma virus vaccine, has been shown to protect against various cancers, including cervical cancer. Common side effects include injection site pain, fever, headaches, and muscle aches. In some individuals, the severe side effec...

  • Article
  • Open Access
1,735 Views
15 Pages

Development and Validation of the Bone Tumor Surgery Complexity Score

  • Annika Frei,
  • Georg Schelling,
  • Philip Heesen,
  • Pietro Giovanoli and
  • Bruno Fuchs

Bone tumors often manifest with non-specific symptoms such as pain and swelling, often posing diagnostic challenges. Optimal treatment requires centralized care in specialized centers, emphasizing the need for complete tumor removal and interdiscipli...

  • Case Report
  • Open Access
2,741 Views
7 Pages

Waldenstrom Macroglobulinemia Recurrence with Bing–Neel Syndrome Presentation

  • Raffaella Capasso,
  • Miriam Buonincontro,
  • Ferdinando Caranci and
  • Antonio Pinto

Bing–Neel syndrome (BNS) is a rare condition that may occur in patients with Waldenstrom macroglobulinemia (WM) and is caused by lymphoplasmacytic infiltration into the central nervous system. BNS is an extramedullary manifestation of WM which...

  • Case Report
  • Open Access
2 Citations
3,770 Views
7 Pages

Proton Pump Inhibitors Induced Hyponatremia in a Liver Transplanted Patient—The Role of Deprescribing: A Case Report and Literature Review

  • Gianmarco Marcianò,
  • Benedetto Caroleo,
  • Luca Catarisano,
  • Donatella Cocchis,
  • Caterina Palleria,
  • Giovambattista De Sarro and
  • Luca Gallelli

Liver transplant patients are frail subjects due to lifelong therapy with immunosuppressants. In these patients, comorbidity and polytherapy increase the risk of adverse drug reactions. In this study, we report the development of hyponatremia, probab...

  • Case Report
  • Open Access
1 Citations
2,986 Views
12 Pages

Leukocyte-Platelet-Rich Fibrin in Bone Regeneration after Periapical Surgery: A 30-Month Follow-Up Clinical Report

  • Hatim A. Qurban,
  • Hatem Hazzaa Hamadallah,
  • Mohammad A. Madkhaly,
  • Muhannad M. Hakeem and
  • Ahmed Yaseen Alqutaibi

26 April 2024

Aim and background: Periapical lesions, which occur due to the infection and necrosis of dental pulp, are a significant dental pathology that poses risks to oral and systemic health. These lesions often require interventions such as root canal treatm...

  • Article
  • Open Access
2 Citations
2,165 Views
8 Pages

26 April 2024

Background: Resistant bacteria causing urinary tract infections (UTI) are becoming increasingly common worldwide. Patients suffering from such UTIs are often elderly, with complex medical backgrounds, and require prolonged hospital stays due to the f...

  • Case Report
  • Open Access
2,865 Views
7 Pages

Complex Presentation of Lung Cancer with Obstructive Jaundice

  • Ruxandra Oprita,
  • Bogdan Oprita,
  • Ioana Adriana Serban,
  • Lidia Aurelia Stefan,
  • Ciprian Mihai Neacsu,
  • Alice Elena Diaconu and
  • Valentin Enache

24 April 2024

Background: Lung cancer, particularly small-cell lung carcinoma (SCLC), often presents with respiratory symptoms. However, atypical manifestations including jaundice and abdominal pain can obscure the diagnosis, leading to challenges in early detecti...

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Reports - ISSN 2571-841X