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Reports, Volume 7, Issue 2

June 2024 - 28 articles

Cover Story: This study estimated the prevalence of drug interactions with chloroquine (CQ) or hydroxychloroquine (HCQ) in COVID-19 inpatients during the pandemic waves and their association with hospitalization-related outcomes. In a sample of 487 patients with a mean age of 77.1 years (47.8% females), hospitalized for COVID-19 from March to December 2020, and treated with CQ or HCQ, we found that 255 (52.4%) had one drug interaction with CQ or HCQ, and 114 (23.4%) had ≥2 interactions. The most frequent drugs interacting with CQ or HCQ were lopinavir/ritonavir, azithromycin, tocilizumab, levofloxacin, clarithromycin, amlodipine, and trazodone. The presence of drug–drug interactions did not seem to impact the hospitalization duration and outcomes. View this paper
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Articles (28)

  • Case Report
  • Open Access
1 Citations
1,874 Views
10 Pages

Primary Melanoma of the Pineal Gland Case Report and Review of the Literature

  • Daniel Rotariu,
  • Bogdan F. Iliescu,
  • Gabriela Dumitrescu,
  • Antonia Nita and
  • Bogdan Costachescu

20 June 2024

Pineal-region tumors are a histologically heterogeneous group of tumors and represent a rare occurrence, accounting for less than 1% of all adult intracranial tumors. Among these, primary pineal malignant melanomas (PPM) represent an even rarer entit...

  • Case Report
  • Open Access
1,946 Views
6 Pages

Complete Left-Sided Pericardial Congenital Absence

  • Petar Kalaydzhiev,
  • Anelia Partenova,
  • Radostina Ilieva,
  • Kamelia Genova and
  • Elena Kinova

20 June 2024

Background: Congenital absence of pericardium is a rare cardiac disorder with a reported incidence of less than 1 in 10,000. Although most of the cases are of little clinical significance, some of them are associated with serious complications, inclu...

  • Case Report
  • Open Access
1,921 Views
6 Pages

14 June 2024

Background: Airway management in Duchenne patients can be challenging. We present a case of an anticipated difficult airway in a 24-year-old Duchenne patient that was managed by planning different suitable strategies based on the unanticipated diffic...

  • Case Report
  • Open Access
1 Citations
2,138 Views
6 Pages

Endoscopic Surgical Approach for a Mesiodens in the Nasal Cavity: A Rare Phenomenon

  • Enzo Iacomino,
  • Chiara Fratini,
  • Federica Zoccali,
  • Francesca Cambria,
  • Matteo Laudani,
  • Alberto Eibenstein,
  • Christian Barbato,
  • Marco de Vincentiis and
  • Antonio Minni

13 June 2024

The nasal cavity is a sporadic site for mesiodens, and if it is impacted in the lower nasal floor or localized in the nasal septum, it may cause various nasal symptoms such as nasal obstruction, recurrent rhinitis, and epistaxis. Early diagnosis is m...

  • Interesting Images
  • Open Access
3,501 Views
5 Pages

Febrile Rash: An Early Diagnostic Clue to Infectious Illness in Travelers Returning from Thailand

  • Hisham Ahmed Imad,
  • Anastasia Putri,
  • Ratchata Charoenwisedsil,
  • Sakarn Charoensakulchai and
  • Eric Caumes

The eruption of a rash along with spiking fever in travelers returning from the tropics may be suspicious of arboviral diseases, and isolation prevent further transmission in non-endemic countries. The case presented here was seen at the Fever Clinic...

  • Case Report
  • Open Access
1 Citations
2,718 Views
9 Pages

Tibial Periprosthetic fractures (PPF) after primary total knee arthroplasty (TKA) are uncommon and mainly occur after trauma. Various management options have been proposed; however, the decision mainly relies on the location of the fracture and the t...

  • Interesting Images
  • Open Access
1,233 Views
3 Pages

While insertion of a central venous catheter (CVC) for intravascular access, diagnosis, and intensive care medical treatment is frequently needed in critically ill patients, retention of the guidewire used for CVC placement with Seldinger’s tec...

  • Article
  • Open Access
2 Citations
2,605 Views
9 Pages

Drug–Drug Interactions of Hydroxychloroquine and Chloroquine in Older Patients with COVID-19 during the First Pandemic Waves: The GeroCovid Observational Study

  • Caterina Trevisan,
  • Andrea Cignarella,
  • Andrea Grandieri,
  • Giuseppe Sergi,
  • Stefano Fumagalli,
  • Fabio Monzani,
  • Chukwuma Okoye,
  • Giuseppe Bellelli,
  • Alba Malara and
  • Pietro Gareri
  • + 3 authors

Objective: Chloroquine (CQ) and hydroxychloroquine (HCQ) were used as off-label treatments for SARS-CoV-2 infection during the first pandemic waves. The urgency of combatting COVID-19 led to the dissemination of medical recommendations with a scarce...

  • Article
  • Open Access
1 Citations
2,091 Views
12 Pages

Background: This study aimed to compare the clinical outcomes of using two different devices to treat upper palatal discrepancies evaluated with a digital intraoral scanner. Methods: A total of 64 patients were enrolled and treated with either an ela...

  • Case Report
  • Open Access
1 Citations
4,171 Views
9 Pages

Descending Necrotizing Mediastinitis in Healthy Young Adults: The Fatal Consequence of the Delayed Help

  • Petar Uchikov,
  • Maria Kraeva,
  • Krasimir Kraev,
  • Bozhidar Hristov,
  • Dzhevdet Chakarov,
  • Nedzhat Ali,
  • Chavdar Stefanov,
  • Angelina Mollova-Kyosebekirova,
  • Tihomir Tenchev and
  • Snezhanka Dragusheva
  • + 2 authors

Introduction: Descending necrotizing mediastinitis is one of the most lethal forms of acute mediastinitis. It originates from an odontogenic or deep neck infection, which descends to the mediastinum through the fascial planes. It is a rare condition,...

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Reports - ISSN 2571-841X