Journal of Mind and Medical Sciences

6 pages, 399 KiB

Open AccessCase Report

Giant Gastric Polyp Mimicking a Duodenal Tumor

by Ioana Duca, Florin Mihaileanu, Alexandra Chira, Romeo Chira, Teodora Surdea Blaga, Diana Popovici, Adriana Albu and Dan Lucian Dumitrascu

J. Mind Med. Sci. 2022, 9(2), 324-329; https://doi.org/10.22543/2392-7674.1316 - 15 Oct 2022

Cited by 1 | Viewed by 90

Abstract

Inflammatory fibroid polyps are very rare gastrointestinal tumors. We present the case of a 66-year-old woman with severe anemia and a giant gastric polyp which had intermittent duodenal intussusception. Ultrasonography showed increased gastric wall thickness and suspected an ampulloma, as revealed also by [...] Read more.

Inflammatory fibroid polyps are very rare gastrointestinal tumors. We present the case of a 66-year-old woman with severe anemia and a giant gastric polyp which had intermittent duodenal intussusception. Ultrasonography showed increased gastric wall thickness and suspected an ampulloma, as revealed also by endoscopy and computed tomography. Ultrasonography reassessment showed later the intragastric mass, which was confirmed by endosonography: giant pediculated hypervascular polyp suggesting malignancy. Challenging phenomena at different investigation methods were due to intermittent protrusion into the first duodenal segment mimicking an ampulloma, but without gastric outlet syndrome or a malignant component, despite the severe anemia. Abnormal US aspect of the stomach in clinical context of anemic syndrome, requires EUS with biopsies in order to confirm underlying lesions. The particularities of this case are the: discordance between imaging aspects and the protrusion into the first duodenal segments with consecutive cholestasis mimicking an ampulloma and the lack of gastric outlet syndrome. Full article

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6 pages, 251 KiB

Open AccessArticle

Nasal Surgery Versus Pharyngeal Surgery in the Treatment of Obstructive Sleep Apnea

by Ruxandra Oana Alius, Viorel Zainea, Catalina Voiosu, Irina Gabriela Ionita, Andreea Rusescu, Oana Denisa Balalau, Catalin Alius, Raluca Oana Pulpa and Razvan Hainarosie

J. Mind Med. Sci. 2022, 9(2), 318-323; https://doi.org/10.22543/2392-7674.1347 - 15 Oct 2022

Cited by 4 | Viewed by 103

Abstract

The endemic spread of obesity and unhealthy behaviors of modern society led to revisiting the real prevalence related to obstructive sleep apnea. Recent data support a paradigm shift towards individually tailored treatments which include functional surgery of the upper airways. This paper presents [...] Read more.

The endemic spread of obesity and unhealthy behaviors of modern society led to revisiting the real prevalence related to obstructive sleep apnea. Recent data support a paradigm shift towards individually tailored treatments which include functional surgery of the upper airways. This paper presents the results of a randomized interventional, prospective study on 68 patients referred by the general practitioner for obstructive sleep apnea. The eligible cohort consisted of 28 patients who were offered functional surgery for definitive relief of obstructive symptoms. After topographic diagnosis of the obstruction site and grading of the severity of the obstructive sleep apnea, the eligible lot was randomized for either nasal surgery or pharyngeal surgery. Subjective and objective measurements were carried out at presentation and three months after surgery. Results showed a significant reduction in AHI (more than 50%) after functional surgery, with marginal benefit for those treated with nasal surgery. Functional improvement is unequivocal for both surgical methods, but the superior results reported in the nasal surgery group could be related to the relatively small size of the study group. The involvement of a larger cohort in subsequent studies with a similar design could confirm these results. Full article

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8 pages, 219 KiB

Open AccessArticle

Clinical and Biological Factors With Prognostic Value in Acute Pancreatitis

by Mihai Faur, Dan Dumitrescu, Dan Sabau, Ciprian Tanasescu, Dan Cretu, Denisa Tanasescu, Vlad Denis Constantin and Calin Mohor

J. Mind Med. Sci. 2022, 9(2), 310-317; https://doi.org/10.22543/2392-7674.1352 - 15 Oct 2022

Cited by 3 | Viewed by 85

Abstract

Acute pancreatitis is an acute inflammatory process of the pancreas, which can remain localized at the level of the gland or can extend to the peripancreatic and retroperitoneal tissues. The use and interpretation of paraclinical examinations at the onset can predict the form [...] Read more.

Acute pancreatitis is an acute inflammatory process of the pancreas, which can remain localized at the level of the gland or can extend to the peripancreatic and retroperitoneal tissues. The use and interpretation of paraclinical examinations at the onset can predict the form of evolution of acute pancreatitis (mild or severe). Depending on the evolution, these data are useful in determining the type of surgical intervention that might be necessary based on severity. We present a retrospective study consisting of 118 patients diagnosed and hospitalized with acute pancreatitis during 2016–2020 in the Surgery I section of the Sibiu County Emergency Clinical Hospital. Several parameters were taken into account at hospitalization such as age, sex, the environment of origin, etiology of pancreatitis, biochemical parameters with their repetition at 24, 72 hours, and at discharge, and clinical signs at hospitalization. surgeries performed depending on the severity of pancreatitis specifying their complications. Full article

6 pages, 226 KiB

Open AccessArticle

Prostate Imaging Reporting and Data System Score (Pi-Rads) and Glutathione S-Transferase P1 Methylation Status (Gst-P1) in the Diagnosis of Prostate Cancer Patients With Borderline PSA Values

by Marius Stan, Vladimir Botnarciuc, Andra I. Suceveanu, Andreea C. Costea, Adrian P. Suceveanu, Laura Mazilu, Ciprian Iorga, Tony Hangan, Corneliu Tudor, Dragos Epistatu, Sergiu Chirila, Viorel Gherghina and Felix Voinea

J. Mind Med. Sci. 2022, 9(2), 304-309; https://doi.org/10.22543/2392-7674.1354 - 15 Oct 2022

Viewed by 149

Abstract

Objectives. The objective of this study was to evaluate the potential use of Prostate Imaging – Reporting and Data System version 2 (PI-RADS) in combination with Glutathione S-transferase P1 (GST-P1) expression for an improved diagnosis of prostate cancer, in patients with inconclusive [...] Read more.

Objectives. The objective of this study was to evaluate the potential use of Prostate Imaging – Reporting and Data System version 2 (PI-RADS) in combination with Glutathione S-transferase P1 (GST-P1) expression for an improved diagnosis of prostate cancer, in patients with inconclusive values of prostate-specific antigen (PSA). Materials and Methods. The study was conducted on 80 patients for whom PSA values were evaluated and were found to be inconclusive (4–10 ng/ml). These patients underwent imagistic evaluation (PI-RADS), followed by transurethral prostate biopsy, with the evaluation of GST-P1 expression and histopathological examination (for diagnosis confirmation). Results. By combining the results of PI-RADS and GST-P1 the capacity of the tests to correctly identify healthy subjects, with an area under curve of 0.832 (95% CI 0.732–0.907), with a sensitivity of 73.25% and a specificity of 77.78%. Conclusions. PI-RADS lesions and GST-P1 methylation testing when PSA levels are in a “grey zone”, provide a better specificity and sensitivity by comparison through single testing. Testing patients with inconclusive PSA levels allows for a more accurate diagnosis and less over-diagnosis by non-invasive procedures, such as repeated biopsies. Full article

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10 pages, 528 KiB

Open AccessArticle

Innovative Therapeutic Approach to Chemical Burns Produced by Vesicants; An Experimental Study

by Cristina Anca Secară, Otilia Liudmila Cinteză, Diana Popescu, Claudia Valentina Popa, Camelia Andreea Hîrjeu, Oana Cristina Voinea, Luiza Georgia Șerbănescu, Andreea Marilena Păuna and Mihail Silviu Tudosie

J. Mind Med. Sci. 2022, 9(2), 294-303; https://doi.org/10.22543/2392-7674.1355 - 15 Oct 2022

Cited by 1 | Viewed by 131

Abstract

Vesicants are compounds that cause severe toxic effects on various tissues. Such chemical action causes tissue necrosis, with clinical expression of skin lesions with a burning character and characteristic blisters. Clinical toxic effects of cutaneous vesicles are correlated with the absorbed dose and [...] Read more.

Vesicants are compounds that cause severe toxic effects on various tissues. Such chemical action causes tissue necrosis, with clinical expression of skin lesions with a burning character and characteristic blisters. Clinical toxic effects of cutaneous vesicles are correlated with the absorbed dose and exposure time. The goals of the study are to evaluate in vitro the skin toxicity produced by the vesicant chemical compound 2-chloroethyl-ethyl sulfide (CEES), to develop a complex antidote formula, and to optimize the therapeutic efficacy by inclusion in controlled release systems. The experimental protocol aims at the in vitro evaluation of the cytotoxicity of the vesicant compound CEES and of the optimized complex antidote, using the MTT cell viability test. Optimization of the complex antidote formula was achieved by developing and in vitro and in vivo testing of a fixed combination of active substances with anti-inflammatory and antioxidant effects, formulated as a solution with cutaneous administration. In vitro cytotoxicity tests on fibroblast cultures revealed the protective effect of the newly developed antidote solution, specifically a dose-related effect in the case of vesicant exposure. Full article

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9 pages, 417 KiB

Open AccessArticle

Modern Therapeutic Options in Diabetic Foot Ulcer

by Denisa Tanasescu, Andrei Moisin, Radu Fleaca, Carmen Popa, Ciprian Bacila, Cosmin Mohor, Claudia Diana Gherman, Bogdan Gaspar and Ciprian Tanasescu

J. Mind Med. Sci. 2022, 9(2), 285-293; https://doi.org/10.22543/2392-7674.1351 - 15 Oct 2022

Cited by 8 | Viewed by 124

Abstract

Diabetic foot is a severe complication of diabetes that occurs as a result of poor glycemic control, being associated with significant morbidity and mortality. Mortality associated with this disease is estimated at 5% in the first 12 months, and about 42% in the [...] Read more.

Diabetic foot is a severe complication of diabetes that occurs as a result of poor glycemic control, being associated with significant morbidity and mortality. Mortality associated with this disease is estimated at 5% in the first 12 months, and about 42% in the next 5 years. On average, it affects about 15% of people with diabetes during their lifetime, including as possible manifestations neuropathy, peripheral vascular disease, and subsequent ulceration which, if treated incorrectly, can lead to amputation. This paper presents a retrospective and descriptive study of patients diagnosed and treated for diabetic foot ulcers in the Proctoven Clinic. The study includes a group of 50 cases diagnosed with diabetic foot over a period of 5 years, from 01.01.2017 to 31.12.2021. In this study, the effectiveness of the modern treatment methods most frequently used in the surgical treatment of the diabetic foot is analyzed based on several parameters. Full article

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9 pages, 256 KiB

Open AccessArticle

Upper Gastrointestinal Bleeding During the COVID-19 Pandemic; Particularities of Diagnosis and Therapy

by Adrian Silaghi, Bogdan Severus Gaspar, Dragos Epistatu, Daniela Gabriela Bălan, Ioana Păunică, Anca Silvia Dumitriu, Stana Paunica, Bogdan Socea and Vlad Denis Constantin

J. Mind Med. Sci. 2022, 9(2), 276-284; https://doi.org/10.22543/2392-7674.1363 - 15 Oct 2022

Cited by 10 | Viewed by 81

Abstract

SARS-COV 2 recently caused a global pandemic, with the first case being reported in Romania in February 2020. Important restrictive measures were imposed, so that the addressability of patients to medical services decreased. Upper gastrointestinal bleeding had more severe forms of evolution at [...] Read more.

SARS-COV 2 recently caused a global pandemic, with the first case being reported in Romania in February 2020. Important restrictive measures were imposed, so that the addressability of patients to medical services decreased. Upper gastrointestinal bleeding had more severe forms of evolution at the time of presentation, which required additional methods of diagnosis and treatment. This is a retrospective study performed on 268 patients, which aims to evaluate the type and effectiveness of different treatment methods for upper gastrointestinal bleeding during the COVID 19 pandemic. Severity assessment was performed by measuring the Rockall score and additional methods of diagnosis. The association of COVID-19 with upper gastrointestinal bleeding can lead to much more severe outcomes for the patient, so treatment must be sustained and fast established. If the initial therapeutic methods fail, the other available therapeutic measures should be introduced progressively and without delay to achieve the best possible outcomes. Full article

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10 pages, 324 KiB

Open AccessArticle

Fear of COVID-19, Anxiety, Depression and Suicide Among Elderly Patients With Chronic Physical or Mental Diseases

by Vasiliki Holeva, Vasiliki Aliki Nikopoulou, Eleni Parlapani, Konstantinos Karkaletsis, Styliani Kokkoni, Dimitrios Nouvakis, Patroklos Theocharis and Ioannis Diakogiannis

J. Mind Med. Sci. 2022, 9(2), 266-275; https://doi.org/10.22543/2392-7674.1318 - 15 Oct 2022

Cited by 3 | Viewed by 98

Abstract

Older age renders individuals vulnerable during public emergency crises. Considering that older adults are a highly heterogeneous and continuously growing demographic subgroup, this study aimed to assess the mental health impact of COVID-19 on two groups of older patients: a group of chronic [...] Read more.

Older age renders individuals vulnerable during public emergency crises. Considering that older adults are a highly heterogeneous and continuously growing demographic subgroup, this study aimed to assess the mental health impact of COVID-19 on two groups of older patients: a group of chronic physical disease and a group of chronic mental disease. A total of 102 patients completed the Fear of COVID-19 Scale, the Generalized Anxiety Disorder scale, the Brief Patient Health Questionnaire (PHQ-9) and several questions regarding demographic characteristics. Suicidality was assessed by the 9th item of the PHQ-9. According to the results, older chronic disease patients showed higher levels of fear, whereas anxiety and depressive symptoms were present mainly in the group of older psychiatric patients. Suicidality was reported from a subtotal of 25.4% that was composed of 7.8% chronic disease patients and 17.6% psychiatric patients. Chronic physical disease and higher anxiety predicted more severe COVID-19-related fear. Full article

11 pages, 377 KiB

Open AccessArticle

Psychological and Psychiatric Characterization of Various Groups of Drugs Users

by Daniela-Mădălina Ciucă Anghel, Elena-Elisabeta Anghel, Miriana Stan, Gheorghe Tudor, Anca Silvia Dumitriu, Stana Paunica and Daniela Luiza Baconi

J. Mind Med. Sci. 2022, 9(2), 255-265; https://doi.org/10.22543/2392-7674.1356 - 15 Oct 2022

Cited by 5 | Viewed by 129

Abstract

Aim. We aimed to assess the differences among various groups of drugs users, especially in the psychiatric and psychological domains. Materials and Methods. A retrospective study was carried out in collaboration with C.E.T.T.T `St. Stelian` Institute from Bucharest. There were analyzed [...] Read more.

Aim. We aimed to assess the differences among various groups of drugs users, especially in the psychiatric and psychological domains. Materials and Methods. A retrospective study was carried out in collaboration with C.E.T.T.T `St. Stelian` Institute from Bucharest. There were analyzed the medical records of 604 hospitalized patients with heroin or polydrug addiction. Results. Significant differences in diagnosis at submission among groups were outlined (personality and behavior disorders, p-value = 0.04298, psychotic disorders, p-value = 0.004274, schizophrenia, p-value = 0.000141) as well as significant differences among psychiatric parameters: perception (legal highs, opiates), attention (cannabis), consciousness (legal highs), thinking (legal highs), and, instinctive life (legal highs). Conclusions. Personality and behavioral disorders have been particularly linked to opiate use, the psychotic disorder was related to cannabis and legal highs intake, while schizophrenia was related to legal highs intake. Full article

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6 pages, 179 KiB

Open AccessReview

Eating Disorders in Men: A Comprehensive Summary

by Connor James Spratt, Liam Alexander MacKenzie Myles and Emanuele Maria Merlo

J. Mind Med. Sci. 2022, 9(2), 249-254; https://doi.org/10.22543/2392-7674.1362 - 15 Oct 2022

Cited by 11 | Viewed by 163

Abstract

Eating disorders (EDs) have detrimental effects on an individual’s physical and mental health, along with significant interpersonal, social and economic effects. Furthermore, men who are suffering with an ED face unique challenges with this. Men suffering with EDs have historically received little attention [...] Read more.

Eating disorders (EDs) have detrimental effects on an individual’s physical and mental health, along with significant interpersonal, social and economic effects. Furthermore, men who are suffering with an ED face unique challenges with this. Men suffering with EDs have historically received little attention within ED research, diagnosis and intervention. However, the number of men suffering with these issues is significant and growing. Understanding of EDs tend to ignore male experiences, meaning many are left to suffer in silence until the ED has developed to a critical point. However, many now recognize the need to understand the issues facing men suffering with an ED. By improving our understanding, we can better improve early detection, diagnosis and treatment for those who are suffering. This paper aims to provide a comprehensive general introduction to this growing area of research and it is hoped that it will be of good use to interested researchers, students and the general public. Prevalence, presentation, history, diagnosis and more will be covered in order to provide a well-rounded understanding of EDs in men. Full article

7 pages, 404 KiB

Open AccessReview

An Algorithm for Indoor SARS-CoV-2 Transmission

by Daniel Maxin and Spencer Gannon

J. Mind Med. Sci. 2022, 9(2), 242-248; https://doi.org/10.22543/2392-7674.1313 - 15 Oct 2022

Viewed by 88

Abstract

We propose a computer modeling approach for SARS-CoV-2 transmission that can be preferable to a purely mathematical framework. It is illustrated its functionality in a specific case of indoor transmission. Based on literature, we assume that infection is due to aerosols with viral [...] Read more.

We propose a computer modeling approach for SARS-CoV-2 transmission that can be preferable to a purely mathematical framework. It is illustrated its functionality in a specific case of indoor transmission. Based on literature, we assume that infection is due to aerosols with viral particles that persist and accumulate for hours in the air even after the persons who produced them left the space. We incorporate also restricted opening hours as a mitigation measure and one possible behavioral change in response to this measure. It is shown via several examples how this algorithmic modeling approach can be used to run various scenarios in order to predict the efficacy of the intervention. Full article

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6 pages, 256 KiB

Open AccessReview

Management of Systemic Lupus Erythematosus in Pregnancy

by Oana Denisa Bălălău, Mihai George Loghin, Delia Maria Bogheanu, Nicolae Bacalbasa, Anca Daniela Stănescu, Daniela Gabriela Bălan, Ioana Păunică and Octavian Gabriel Olaru

J. Mind Med. Sci. 2022, 9(2), 236-241; https://doi.org/10.22543/2392-7674.1358 - 15 Oct 2022

Cited by 1 | Viewed by 131

Abstract

Systemic lupus erythematosus is one of the most common autoimmune disorders affecting young women. Pregnant women with lupus are generally at higher risk for certain pregnancy complications than women without comorbidities. Even so, a pregnancy with lupus can be carried to term in [...] Read more.

Systemic lupus erythematosus is one of the most common autoimmune disorders affecting young women. Pregnant women with lupus are generally at higher risk for certain pregnancy complications than women without comorbidities. Even so, a pregnancy with lupus can be carried to term in optimal conditions if it is properly managed by a doctor. Monitoring is generally recommended six months after the onset of lupus symptoms, and ideally there should be no active lupus symptoms prior to conception. General screening tests should include the anti-phospholipid, anti-Ro and anti-La antibodies. Women who are positive for these antibodies have an increased risk of congenital heart block in the fetus. In addition, pregnant women with lupus have an increased risk of spontaneous abortion, intrauterine fetal growth restriction, pre-term birth, while neonatal lupus syndrome is a major fetal condition. The maternal risks are faced with disease flares, pre-eclampsia and other complications. Treatment options during pregnancy are limited to a few safe medications. For example, prednisone is unlikely to cause fetal malformations, but it increases the risk of diabetes and high blood pressure in the mother. Consequently, a careful multidisciplinary monitoring is essential for optimal results in pregnancy with lupus. Full article

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12 pages, 525 KiB

Open AccessReview

SARS-CoV-2 Omicron (B.1.1.529) Variant: Structural Features, Biological Characteristics, Impact on Scientific Research, General Precautions and Protective Procedures; A Systematic Review

by Prithivi Nagarajan, Anitha Vetrivel, Jayanthi Kumar, Anusheela Howlader, Kumar Rangarajalu, Satheesh Kumar Sabapathy, Muthu Gopal and Saravanaavel Kumar

J. Mind Med. Sci. 2022, 9(2), 224-235; https://doi.org/10.22543/2392-7674.1343 - 15 Oct 2022

Cited by 3 | Viewed by 93

Abstract

The SARS-CoV-2 mutations that have occurred have alarmed the entire medical community. Thus, global concerns have been expressed regarding the transmission, pathogenicity and immune evasion of the Omicron strain, which shares mutations with the variants of concern Alpha, Beta, and Gamma strains. Still, [...] Read more.

The SARS-CoV-2 mutations that have occurred have alarmed the entire medical community. Thus, global concerns have been expressed regarding the transmission, pathogenicity and immune evasion of the Omicron strain, which shares mutations with the variants of concern Alpha, Beta, and Gamma strains. Still, Omicron transmission has crossed numerous borders worldwide compared to other types of SARS-CoV-2. The number of confirmed cases has increased and is reappearing in India. Given the worrisome situation created by the Omicron outbreak, scientists and postgraduates have had to make decisions about current research programs at institutions around the globe. The Omicron variants under development have significantly heightened worldwide pandemic concerns. In this review, the authors will outline the molecular features and efficacy of vaccination, highlight possible omicron impacts on scientific research, and provide precautions, procedural guidelines for organizing scientific meetings during a pandemic. Full article

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15 pages, 241 KiB

Open AccessReview

Limb Amputations; Etiopathogenesis, Diagnosis and the Multidisciplinary Therapeutic Approach

by Vlad Denis Constantin, Bogdan Socea, Bogdan Severus Gaspar, Dragos Epistatu, Ioana Paunica, Anca Silvia Dumitriu, Stana Paunica and Adrian Silaghi

J. Mind Med. Sci. 2022, 9(2), 209-223; https://doi.org/10.22543/2392-7674.1361 - 15 Oct 2022

Cited by 6 | Viewed by 91

Abstract

Despite remarkable advances in medicine, limb amputations remain a therapeutic measure that saves the lives of many patients. Given the varied etiopathogenesis, such operations are performed both as an emergency and as an elective procedure. Such interventions address either only the distal segments [...] Read more.

Despite remarkable advances in medicine, limb amputations remain a therapeutic measure that saves the lives of many patients. Given the varied etiopathogenesis, such operations are performed both as an emergency and as an elective procedure. Such interventions address either only the distal segments of a limb, or even the entire limb, having a great psychological, functional and social impact on the patient. Due to these multiple implications, limb amputations must be performed by specialized teams, in order to achieve the best possible functional and aesthetic results to be compatible with the correction of the remaining deficit with a prosthesis. The main causes leading to amputations and the corresponding preventive measures are presented, as well as the general principles of amputations as a therapeutic solution of last resort. In conclusion, reducing the number of traffic/workplace accidents and effective treatment of chronic diseases affecting the vascular system can contribute to decreasing the need for amputations, a life-saving therapeutic solution, but with a devastating impact on the patient and society. Full article

7 pages, 195 KiB

Open AccessReview

Dental Fear, Anxiety, and Phobia; Causes, Diagnostic Criteria and the Medical and Social Impact

by Nadya Tsetsova Avramova

J. Mind Med. Sci. 2022, 9(2), 202-208; https://doi.org/10.22543/2392-7674.1348 - 15 Oct 2022

Cited by 9 | Viewed by 311

Abstract

Despite technological advances in modern medical science and practice, many people still associate dental treatment with unpleasant emotional sensations and pain. According to the current literature, dental fear and anxiety are psychological barriers that negatively affect frequency of patient attendance which results in [...] Read more.

Despite technological advances in modern medical science and practice, many people still associate dental treatment with unpleasant emotional sensations and pain. According to the current literature, dental fear and anxiety are psychological barriers that negatively affect frequency of patient attendance which results in avoidant behavior and poorer oral health-related quality of life. This paper was therefore aimed at discussing basic theoretical aspects concerning diagnostic criteria, causes, and impacts of dental fear, anxiety, and phobia. Clarifying their differential diagnostic characteristics, clinical features and specific causes may play an important role in proper diagnosing, positive influencing, and management of this group of patients, thus providing the opportunity for increasing quality of dental healthcare services as well as improving patient’s dental health and self-perceived quality of life. Full article

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J. Mind Med. Sci., Volume 9, Issue 2 (October 2022) – 15 articles

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