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Tomography, Volume 11, Issue 6

June 2025 - 13 articles

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Cover Story: This study investigates whether advanced CZT SPECT technology’s superior image quality translates to improved diagnostic accuracy for Alzheimer’s disease. We compared conventional SPECT (eCAM) with CZT SPECT in 29 patients with suspected neurodegenerative diseases. Despite CZT SPECT showing significantly higher gray matter/white matter contrast (1.615 vs. 1.458, p < 0.001), diagnostic accuracy for AD did not improve. Both participating clinicians experienced decreased sensitivity or specificity with CZT images. These findings reveal an important paradox: enhanced image clarity does not automatically enhance diagnostic performance, highlighting the need for specialized training to fully leverage advanced imaging technology in neurodegenerative disease diagnosis. View this paper

Articles (13)

  • Article
  • Open Access
1 Citations
774 Views
15 Pages
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Longitudinal Overlap and Metabolite Analysis in Spectroscopic MRI-Guided Proton Beam Therapy in Pediatric High-Grade Glioma

  • Abinand C. Rejimon,
  • Anuradha G. Trivedi,
  • Vicki Huang,
  • Karthik K. Ramesh,
  • Natia Esiashvilli,
  • Eduard Schreibmann,
  • Hyunsuk Shim,
  • Kartik Reddy and
  • Bree R. Eaton
Tomography2025, 11(6), 71;https://doi.org/10.3390/tomography11060071

19 June 2025

Background: Pediatric high-grade glioma (pHGG) is a highly aggressive cancer with unique biology distinct from adult high-grade glioma, limiting the effectiveness of standard treatment protocols derived from adult research. Objective: The purpose of...

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  • Article
  • Open Access
1 Citations
643 Views
14 Pages
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Assessment of Mandibular Bone Architecture in Patients with Endocrine Disorders Using Fractal Dimension and Histogram Analysis

  • Elif Yıldızer,
  • Saliha Kubra Sari,
  • Fatih Peker,
  • Ali Riza Erdogan,
  • Kevser Sancak and
  • Sinan Yasin Ertem
Tomography2025, 11(6), 70;https://doi.org/10.3390/tomography11060070

18 June 2025

Objective: Endocrine disorders, including diabetes mellitus and thyroid dysfunctions, can significantly impact bone metabolism and structure. This study aimed to assess mandibular trabecular architecture in patients with type 1 diabetes mellitus (T1D...

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  • Article
  • Open Access
904 Views
19 Pages
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Structured Transformation of Unstructured Prostate MRI Reports Using Large Language Models

  • Luca Di Palma,
  • Fatemeh Darvizeh,
  • Marco Alì and
  • Deborah Fazzini
Tomography2025, 11(6), 69;https://doi.org/10.3390/tomography11060069

17 June 2025

Objectives: to assess the ability of high-performing open-weight large language models (LLMs) in extracting key radiological features from prostate MRI reports. Methods: Five LLMs (Llama3.3, DeepSeek-R1-Llama3.3, Phi4, Gemma-2, and Qwen2.5-14B) were...

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  • Review
  • Open Access
1,873 Views
26 Pages
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Applications of Advanced Imaging for Radiotherapy Planning and Response Assessment in the Central Nervous System

  • Liam S. P. Lawrence,
  • Rachel W. Chan,
  • Amit Singnurkar,
  • Jay Detsky,
  • Chris Heyn,
  • Pejman J. Maralani,
  • Hany Soliman,
  • Greg J. Stanisz,
  • Arjun Sahgal and
  • Angus Z. Lau
Tomography2025, 11(6), 68;https://doi.org/10.3390/tomography11060068

12 June 2025

Background/Objectives: Radiotherapy for tumors of the central nervous system (CNS) could be improved by incorporating advanced imaging techniques into treatment planning and response assessment. The objective of this narrative review is to highlight...

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  • Article
  • Open Access
957 Views
12 Pages
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Determination of the Most Suitable Cut-Off Point of the Cervical Foraminal Cross-Sectional Area at the C5/6 Level to Predict Cervical Foraminal Bony Stenosis

  • Joohyun Lee,
  • Jee Young Lee,
  • Keum Nae Kang,
  • Jae Ni Jang,
  • Sukhee Park and
  • Young Uk Kim
Tomography2025, 11(6), 67;https://doi.org/10.3390/tomography11060067

10 June 2025

Background: Cervical foraminal bony stenosis (CFBS) is a common degenerative spinal condition that causes radicular pain and functional impairment in the upper extremities. Accurate and objective diagnosis of CFBS remains challenging due to the absen...

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  • Article
  • Open Access
1,471 Views
15 Pages
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Image Quality and Lesion Detectability with Low-Monoenergetic Imaging: A Study of Low-Concentration Iodine Contrast in Hepatic Multiphase CT for Chronic Liver Disease

  • Jae En Kim,
  • Yewon Lim,
  • Jin Sil Kim,
  • Hyo Jeong Lee,
  • Jeong Kyong Lee and
  • Hye Ah Lee
Tomography2025, 11(6), 66;https://doi.org/10.3390/tomography11060066

4 June 2025

Background: This study aimed to evaluate whether low-concentration iodine contrast-enhanced multiphase low-monoenergetic computed tomography (LCLM CT; 270 mg I/mL, 40 keV) is non-inferior to standard-dose computed tomography (SDCT; 350 mg I/mL) in im...

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  • Article
  • Open Access
2,170 Views
15 Pages
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Optimizing Radiation Risk Assessment in CT Imaging: Establishing Institutional Diagnostic Reference Levels and Personalized Dose Strategies for Chest, Abdomen, and Pelvis Scans

  • Zuhal Y. Hamd,
  • Huda I. Almohammed,
  • Elbagir Mansour,
  • Abdoelrahman Hassan A. B. and
  • Awadia Gareeballah
Tomography2025, 11(6), 65;https://doi.org/10.3390/tomography11060065

3 June 2025

Background: As a diagnostic radiology procedure, computed tomography (CT) contributes to patient radiation exposure; hence, it deserves special consideration. The use of diagnostic reference levels (DRLs) is an efficient way to optimize patient radia...

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  • Article
  • Open Access
3,403 Views
19 Pages
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Role of Amide Proton Transfer Weighted MRI in Predicting MGMTp Methylation Status, p53-Status, Ki-67 Index, IDH-Status, and ATRX Expression in WHO Grade 4 High Grade Glioma

  • Faris Durmo,
  • Jimmy Lätt,
  • Anna Rydelius,
  • Elisabet Englund,
  • Tim Salomonsson,
  • Patrick Liebig,
  • Johan Bengzon,
  • Peter C. M. van Zijl,
  • Linda Knutsson and
  • Pia C. Sundgren
Tomography2025, 11(6), 64;https://doi.org/10.3390/tomography11060064

31 May 2025

Objectives: To assess amide proton transfer weighted (APTw) MR imaging capabilities in differentiating high-grade glial tumors across alpha-thalassemia/mental retardation X-linked (ATRX) expression, tumor-suppressor protein p53 expression (p53), O6-m...

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  • Review
  • Open Access
1,523 Views
18 Pages
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Current Update on DWI-MRI and Its Radiomics in Liver Fibrosis—A Review of the Literature

  • Ali S. Alyami
Tomography2025, 11(6), 63;https://doi.org/10.3390/tomography11060063

30 May 2025

Introduction: Diffusion-weighted imaging (DWI) is a non-invasive technique for acquiring liver pathology data and characterizing liver lesions. This modality shows promise for applications in the initial diagnosis and monitoring of liver diseases, pr...

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  • Review
  • Open Access
1,523 Views
15 Pages
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Development of Cardiac Computed Tomography for Evaluation of Aortic Valve Stenosis

  • Hiroyuki Takaoka,
  • Haruka Sasaki,
  • Joji Ota,
  • Yoshitada Noguchi,
  • Moe Matsumoto,
  • Kazuki Yoshida,
  • Katsuya Suzuki,
  • Shuhei Aoki,
  • Satomi Yashima and
  • Makiko Kinoshita
  • + 2 authors
Tomography2025, 11(6), 62;https://doi.org/10.3390/tomography11060062

28 May 2025

Aortic valve stenosis (AS) is a valvular heart disease that imposes a high afterload on the left ventricle (LV) due to restricted opening of the aortic valve, resulting in LV hypertrophy. Severe AS can lead to syncope, angina pectoris, and heart fail...

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