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Allergies, Volume 5, Issue 2

2025 June - 13 articles

Cover Story: Herein, we investigate the molecular puzzle linking atopic dermatitis (AD), allergic rhinitis (AR), and chronic rhinosinusitis with nasal polyps (CRSwNP)—three interconnected type two inflammatory diseases. By integrating alterations in DNA methylation, histone modifications, and microRNAs—combined with genetic predispositions and microbial dysbiosis—that converge to drive inflammation, barrier dysfunction, and tissue remodeling across skin and airway diseases, we highlight common molecular markers such as Th2 cytokines (IL-4, IL-5, and IL-13), periostin, matrix metalloproteinases, and key regulatory miRNAs such as miR-146a and miR-155. This review underscores the promise of biologics, miRNA-targeted therapies, and MMP inhibitors in advancing personalized care. View this paper
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Articles (13)

  • Article
  • Open Access
2,143 Views
10 Pages

Pneumococcal Vaccine in Patients with Recurrent Infections

  • Mariana de Gouveia-Pereira Pimentel,
  • Carolina Sanchez Aranda,
  • Rafaela Rola Guimarães,
  • Edson Kiyotaka Ishizuka,
  • Dirceu Solé and
  • Antônio Condino-Neto

Purpose: This study aimed to evaluate the immunological response to the 23-valent pneumococcal polysaccharide vaccine (PPV23) in patients investigated for immunodeficiencies due to recurrent infections at EPM-UNIFESP Clinical Immunology outpatient cl...

  • Review
  • Open Access
3,276 Views
14 Pages

Hidradenitis suppurativa (HS) and atopic dermatitis (AD) are both inflammatory dermatoses that can significantly impact patient quality of life, however, limited research exists regarding their association. The purpose of this comprehensive review is...

  • Review
  • Open Access
5 Citations
14,859 Views
13 Pages

New Therapies in the Biological Treatment of Psoriasis: A Review

  • Mateusz Kamil Ożóg,
  • Alicja Derkacz,
  • Dawid Klimczak,
  • Sara Winkler and
  • Laura Wojciuch

Psoriasis is a chronic inflammatory autoimmune disease primarily affecting the skin and, in some cases, the joints, and is characterized by erythematous, scaling lesions. Building up the doses has been conventional, but many patients will not obtain...

  • Review
  • Open Access
1 Citations
5,189 Views
17 Pages

The interplay between allergic diseases and neurological disorders has gained increasing attention over the past decades, highlighting potential shared pathophysiological pathways. Allergic diseases, including asthma, eczema, and allergic rhinitis, a...

  • Review
  • Open Access
3,866 Views
21 Pages

Endoscopic Dilation for Fibrostenotic Complications in Eosinophilic Esophagitis—A Narrative Review

  • Marco Michelon,
  • Edoardo Vincenzo Savarino,
  • Michele Montori,
  • Maria Eva Argenziano,
  • Pieter Jan Poortmans,
  • Pierfrancesco Visaggi,
  • Roberto Penagini,
  • David J. Tate,
  • Marina Coletta and
  • Andrea Sorge

Esophageal fibrotic remodeling is a major complication of chronic inflammation in eosinophilic esophagitis (EoE) and represents one of the main determinants of symptoms in adult patients with EoE, with a remarkable impact on patients’ quality o...

  • Article
  • Open Access
2 Citations
3,604 Views
17 Pages

Allergic rhinitis and asthma are significant public health concerns worldwide. While previous studies have explored how nasal and buccal bacteriotas influence these conditions, few have directly compared their bacteriomes within the same cohort. To b...

  • Review
  • Open Access
4 Citations
6,761 Views
18 Pages

Population growth and the depletion of natural resources have driven the incorporation of edible insects into the human food matrix. Despite their high nutritional value and the environmental benefits of insect farming compared to conventional protei...

  • Article
  • Open Access
2,094 Views
13 Pages

Pediatric asthma is the most common chronic childhood disease in the US and a major public health concern. It is considered to comprise multiple clinical variants or phenotypes with different etiologies and pathophysiologies. Former research has show...

  • Article
  • Open Access
1,344 Views
8 Pages

D-2-Hydroxyglutarate Attenuates Sinonasal Inflammation in Murine Allergic Rhinitis

  • Anuj Tharakan,
  • Ankit Kumar,
  • Carmen Camarena,
  • Daniel H. Conrad and
  • Rebecca K. Martin

Introduction: Allergic rhinitis (AR) is largely driven by IgE-induced immune cell activation, which promotes allergen-induced upper airway inflammation. The regulatory mechanisms of IgE synthesis in AR are poorly understood. Several analyses associat...

  • Review
  • Open Access
10,483 Views
11 Pages

Should the Cat Stay Home? A Guide to Managing Cat Allergies

  • Ramin Beheshti,
  • Polly Huang,
  • Megan Le,
  • Rachel Peterson and
  • Jody R. Tversky

Worldwide, cat allergies affect 15% of the population. Cat allergens are ubiquitous and challenging to eliminate from homes, making it difficult to implement effective allergen reduction strategies. Developing strategies to reduce cat allergens in ho...

  • Article
  • Open Access
2,510 Views
19 Pages

Aptamer-Enhanced Surface Decontamination: A Novel Approach for Neutralizing Peanut Allergens and Preventing Cell-Degranulation

  • Mohamad Ammar Ayass,
  • Trivendra Tripathi,
  • Natalya Griko,
  • Ramya Ramankutty Nair,
  • Tutku Okyay,
  • Jin Zhang,
  • Kevin Zhu,
  • Victor Pashkov and
  • Lina Abi-Mosleh

Peanut allergies, driven by sensitization to key allergens Ara h1, Ara h2, and Ara h3, present significant health risks, particularly in food processing and consumer settings where accidental exposure is frequent. To mitigate this risk, we developed...

  • Review
  • Open Access
4,384 Views
14 Pages

(1) Background: Allergic disorders and systemic lupus erythematosus (SLE) are immune dysregulation conditions that are increasingly prevalent, with growing evidence suggesting shared pathogenesis. (2) Results: Patients with SLE have a higher risk of...

  • Review
  • Open Access
1 Citations
5,964 Views
26 Pages

Genetic and Epigenetic Interconnections Between Atopic Dermatitis, Allergic Rhinitis, and Rhinitis with Nasal Polyps

  • Alexandra Danielidi,
  • Spyridon Lygeros,
  • Alexandra Anastogianni,
  • Gerasimos Danielidis,
  • Sophia Georgiou,
  • Constantinos Stathopoulos and
  • Katerina Grafanaki

Background: Atopic dermatitis (AD), allergic rhinitis (AR), and chronic rhinosinusitis with nasal polyps (CRSwNP) represent interconnected conditions within the spectrum of type 2 inflammatory diseases. While these conditions share common genetic and...

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Allergies - ISSN 2313-5786