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Allergies, Volume 4, Issue 1

March 2024 - 2 articles

Cover Story: Allergens can be subdivided into a limited number of families based on their structure, despite originating from various sources. However, this family affiliation does not necessarily indicate the allergen’s origin or route of administration, and the molecular basis of allergenicity remains unclear. Understanding the allergenicity of proteins requires their structural characterization and the study of conformational diversity. Allergic reactions are affected by pH, proteolytic susceptibility, and endosomal degradation, which are correlated with conformational changes and secondary structure rearrangement events. It is important to consider structural diversity, dynamics, proteolytic susceptibility, and pH-dependent factors to fully comprehend allergenicity. View this paper

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Review

6 Citations

11,417 Views

13 Pages

Mechanisms and Comparative Treatments of Allergic Rhinitis including Phototherapy

Roy Kennedy

Allergies2024, 4(1), 17-29;https://doi.org/10.3390/allergies4010002

16 February 2024

The treatment of allergic conditions presents a challenge for both seasonal allergic rhinitis and perennial rhinitis sufferers. The increasing prevalence of both of these types of allergic responses requires the use of a range of treatments which can...

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Review

8 Citations

6,417 Views

16 Pages

Allergenicity and Conformational Diversity of Allergens

Clarissa A. Seidler,
Ricarda Zeindl,
Monica L. Fernández-Quintero,
Martin Tollinger and
Klaus R. Liedl

Allergies2024, 4(1), 1-16;https://doi.org/10.3390/allergies4010001

11 January 2024

Allergens are substances that cause abnormal immune responses and can originate from various sources. IgE-mediated allergies are one of the most common and severe types of allergies, affecting more than 20% of the population in Western countries. All...

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Allergies - ISSN 2313-5786|Creative Common CC BY license

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