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Article

Yeast Nanometric Scale Oscillations Highlights Fibronectin Induced Changes in C. albicans

1
Laboratoire de Physique de la Matière Vivante, EPFL, 1015 Lausanne, Switzerland
2
Institute of Microbiology, Lausanne University Hospital, CH-1011 Lausanne, Switzerland
3
International Joint Research Group VUB-EPFL NanoBiotechnology & NanoMedicine (NANO), Vrije Universiteit Brussel, 1050 Brussels, Belgium
4
Research Group Structural Biology Brussels, Alliance Research Group VUB-UGent NanoMicrobiology (NAMI), 1050 Ixelles, Belgium
5
Department Bioscience Engineering, University Antwerp, 2000 Antwerp, Belgium
6
Plateforme de Morphologie UFAM, CUMRL, University of Lausanne, 1015 Lausanne, Switzerland
*
Author to whom correspondence should be addressed.
Fermentation 2020, 6(1), 28; https://doi.org/10.3390/fermentation6010028
Received: 18 December 2019 / Revised: 12 February 2020 / Accepted: 19 February 2020 / Published: 21 February 2020
(This article belongs to the Special Issue Yeast Biotechnology 3.0)
Yeast resistance to antifungal drugs is a major public health issue. Fungal adhesion onto the host mucosal surface is still a partially unknown phenomenon that is modulated by several actors among which fibronectin plays an important role. Targeting the yeast adhesion onto the mucosal surface could lead to potentially highly efficient treatments. In this work, we explored the effect of fibronectin on the nanomotion pattern of different Candida albicans strains by atomic force microscopy (AFM)-based nanomotion detection and correlated the cellular oscillations to the yeast adhesion onto epithelial cells. Preliminary results demonstrate that strongly adhering strains reduce their nanomotion activity upon fibronectin exposure whereas low adhering Candida remain unaffected. These results open novel avenues to explore cellular reactions upon exposure to stimulating agents and possibly to monitor in a rapid and simple manner adhesive properties of C. albicans. View Full-Text
Keywords: Candida albicans; adhesion; fibronectin; nanomotion; atomic force microscope (AFM) Candida albicans; adhesion; fibronectin; nanomotion; atomic force microscope (AFM)
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MDPI and ACS Style

Kohler, A.-C.; Venturelli, L.; Kannan, A.; Sanglard, D.; Dietler, G.; Willaert, R.; Kasas, S. Yeast Nanometric Scale Oscillations Highlights Fibronectin Induced Changes in C. albicans. Fermentation 2020, 6, 28. https://doi.org/10.3390/fermentation6010028

AMA Style

Kohler A-C, Venturelli L, Kannan A, Sanglard D, Dietler G, Willaert R, Kasas S. Yeast Nanometric Scale Oscillations Highlights Fibronectin Induced Changes in C. albicans. Fermentation. 2020; 6(1):28. https://doi.org/10.3390/fermentation6010028

Chicago/Turabian Style

Kohler, Anne-Céline, Leonardo Venturelli, Abhilash Kannan, Dominique Sanglard, Giovanni Dietler, Ronnie Willaert, and Sandor Kasas. 2020. "Yeast Nanometric Scale Oscillations Highlights Fibronectin Induced Changes in C. albicans" Fermentation 6, no. 1: 28. https://doi.org/10.3390/fermentation6010028

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