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Non-Coding RNA, Volume 8, Issue 4
2022 August - 18 articles
Cover Story: In diabetic kidney disease when various cellular functions are impaired, mesangial cells are crucial for the maintenance of the glomerular environment. However, diabetes-evoked dysregulation can result in both mesangial proliferation and apoptosis. It still needs to be elucidated which factors cause the decision for one or the other way. Here, we analyzed and discussed the relevance of the interplay of the lncRNA NEAT1 and the miRNA miR-339-5p for mesangial cell physiology in several injury models. While NEAT1 is mainly upregulated in cancer cells promoting, e.g., proliferation, we observed a reduced mesangial NEAT1 expression. Silencing NEAT1 resulted in differential expression of various coding genes and miRNAs, especially miR-339-5p, which was upregulated. Overexpression of miR-339-5p caused a similar phenotype, such as a knockdown of NEAT1. View this paper
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Non-Coding RNA - ISSN 2311-553X