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Non-Coding RNA, Volume 6, Issue 3
September 2020 - 16 articles
Cover Story: Non-coding RNAs are grouped by size, where those smaller than 200 nucleotides are defined as small non-coding RNAs and those longer than 200 nt are defined as long non-coding RNAs. The ncRNAs are key regulators in a wide range of cellular processes such as transcription, translation, RNA processing, and signalling. The lncRNAs can function via three general mechanisms: interaction with DNA, RNA modulation, and protein modulation. They are commonly dysregulated in disease and have recently been implicated in cancer. Many lncRNAs are differentially expressed in NSCLC, where, generally, upregulated lncRNAs function as tumour promoters and downregulated lncRNAs function as tumour suppressors. However, their precise mechanisms that lead to alterations in cancer cell proliferation, survival, migration, invasion, epithelial-to-mesenchymal transition (EMT), and metastasis are not fully understood. View this paper
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Non-Coding RNA - ISSN 2311-553X