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Non-Coding RNA, Volume 6, Issue 2
June 2020 - 10 articles
Cover Story: We hypothesized that circulating microRNAs (miRNAs) act as morphogenetic inhibitors in shaping the tumor border of cancers. Using a reaction diffusion model, we observed that the diffusion coefficient of miRNAs is a major factor influencing the invasion front configuration. Three different cell generations are represented: parental, F1 and F2. If the concertation of activator and miRNA inhibitor does not change in parental cells, F1 and F2 cells preserve the same fate type and the tumor border is smooth (left). If the activator (a) and miRNA inhibitor (h) diffuse into neighboring parental cells, new cell fate types emerge, and the tumor border becomes irregular (right). From a translational perspective, our observations can be used for better diagnosis of cancer aggressiveness. View this paper
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Non-Coding RNA - ISSN 2311-553X