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Non-Coding RNA, Volume 5, Issue 1
March 2019 - 30 articles
Cover Story: Gastrotrichs—’hairy bellies’—are microscopic free-living animals that were historically placed close to nematodes, but recent phylogenomic analyses have suggested a close relationship to flatworms. To resolve this long-standing question, in a ‘multi-omics’ approach, we used small-RNA sequencing and available transcriptome and genomic data to unravel the miRNA- and piRNA complements along with the RNAi protein machinery of Lepidodermella squamata. We identified 52 miRNA genes with overall high similarities to flatworm miRNA complements. In addition, we found four large piRNA clusters that also resemble flatworm piRNAs but not those earlier described for nematodes. Congruently, transcriptomic annotation revealed that the Lepidodermella protein machinery is highly similar to flatworms, too. View this paper.
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Non-Coding RNA - ISSN 2311-553X