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Non-Coding RNA, Volume 8, Issue 3

June 2022 - 15 articles

Cover Story: Small RNA sequencing (sRNA-Seq) approaches reveal potentially functional RNA sequences derived from longer non-coding RNAs. However, RNAs shorter than 16 nucleotides (nt) are often removed from sequencing libraries/analyses, although they may be functional. Here, we compiled a comprehensive repertoire of small RNAs from 6 different eukaryotic organisms in an extended window of 8 to 30 nt RNA length. Among others, we show in this study that unusually short RNAs <16 nt appear to be more abundant than those >16 nt in bilaterian organisms. Notably, RNAs between 8 and 15 nt predominantly represent non-coding RNA fragments, such as semi-microRNAs, pRFs, sdRNAs, tRFs, and rRFs. We propose that the lower threshold of RNA length be reduced in sRNA-Seq analyses and datasets, as their abundance and diversity support their potential role as biomarkers of disease and/or mediators of cell function. View this paper

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Article

3,640 Views

12 Pages

Identification of Two Exosomal miRNAs in Circulating Blood of Cancer Patients by Using Integrative Transcriptome and Network Analysis

Andrés Rincón-Riveros,
Josefa Antonia Rodríguez,
Victoria E. Villegas and
Liliana López-Kleine

Non-Coding RNA2022, 8(3), 33;https://doi.org/10.3390/ncrna8030033

12 May 2022

Exosomes carry molecules of great biological and clinical interest, such as miRNAs. The contents of exosomes vary between healthy controls and cancer patients. Therefore, miRNAs and other molecules transported in exosomes are considered a potential s...

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Article

6 Citations

4,415 Views

19 Pages

Comprehensive Transcriptional Profiling and Mouse Phenotyping Reveals Dispensable Role for Adipose Tissue Selective Long Noncoding RNA Gm15551

Christoph Andreas Engelhard,
Chien Huang,
Sajjad Khani,
Petr Kasparek,
Jan Prochazka,
Jan Rozman,
David Pajuelo Reguera,
Radislav Sedlacek and
Jan-Wilhelm Kornfeld

Non-Coding RNA2022, 8(3), 32;https://doi.org/10.3390/ncrna8030032

6 May 2022

Cold and nutrient-activated brown adipose tissue (BAT) is capable of increasing systemic energy expenditure via the uncoupled respiration and secretion of endocrine factors, thereby protecting mice against diet-induced obesity and improving insulin r...

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Editorial

1 Citations

3,305 Views

5 Pages

The Non-Coding RNA Journal Club: Highlights on Recent Papers—11

Hélène Bonnet,
Baptiste Bogard,
Florent Hubé,
Mirolyuba Ilieva,
Shziuka Uchida,
Maria Ascensión Ariza-Mateos,
Alexander Serganov,
Barbara Pardini,
Alessio Naccarati and
Gaetano Santulli
+ 3 authors

Non-Coding RNA2022, 8(3), 31;https://doi.org/10.3390/ncrna8030031

5 May 2022

We are delighted to share with you our eleventh Journal Club and highlight some of the most interesting papers published recently [...]

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Article

5 Citations

4,443 Views

16 Pages

ITAS: Integrated Transcript Annotation for Small RNA

Alexey Stupnikov,
Vitaly Bezuglov,
Ivan Skakov,
Victoria Shtratnikova,
J. Richard Pilsner,
Alexander Suvorov and
Oleg Sergeyev

Non-Coding RNA2022, 8(3), 30;https://doi.org/10.3390/ncrna8030030

2 May 2022

Transcriptomics analysis of various small RNA (sRNA) biotypes is a new and rapidly developing field. Annotations for microRNAs, tRNAs, piRNAs and rRNAs contain information on transcript sequences and loci that is vital for downstream analyses. Severa...

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Review

16 Citations

6,293 Views

28 Pages

Context-Dependent Regulation of Gene Expression by Non-Canonical Small RNAs

Kinga Plawgo and
Katarzyna Dorota Raczynska

Non-Coding RNA2022, 8(3), 29;https://doi.org/10.3390/ncrna8030029

29 April 2022

In recent functional genomics studies, a large number of non-coding RNAs have been identified. It has become increasingly apparent that noncoding RNAs are crucial players in a wide range of cellular and physiological functions. They have been shown t...

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