Next Article in Journal
Association between Triplex-Forming Sites of Cardiac Long Noncoding RNA GATA6-AS1 and Chromatin Organization
Previous Article in Journal
Tumor Suppressive Effects of GAS5 in Cancer Cells
 
 
Article

LINC00892 Is an lncRNA Induced by T Cell Activation and Expressed by Follicular Lymphoma-Resident T Helper Cells

1
Department of Pathology, Hematopathology Section and Lymph Node Registry, University of Kiel, 24105 Kiel, Germany
2
Institute of Genetics and Biophysics “A. Buzzati-Traverso”, Consiglio Nazionale delle Ricerche, 80131 Naples, Italy
3
Institute of Human Genetics, Ulm University, Ulm University Medical Center, 89081 Ulm, Germany
4
ecSeq Bioinformatics GmbH, 04103 Leipzig, Germany
5
Institute for Transfusion Medicine and Gene Therapy, Medical Center—University of Freiburg, 79106 Freiburg, Germany
6
Leibniz Institute on Aging—Fritz Lipmann Institute (FLI), 07745 Jena, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Dimitris Lagos
Non-Coding RNA 2022, 8(3), 40; https://doi.org/10.3390/ncrna8030040
Received: 20 April 2022 / Revised: 10 May 2022 / Accepted: 25 May 2022 / Published: 1 June 2022
Successful immunotherapy in both solid tumors and in hematological malignancies relies on the ability of T lymphocytes to infiltrate the cancer tissue and mount an immune response against the tumor. Biomarkers able to discern the amount and the types of T lymphocytes infiltrating a given tumor therefore have high diagnostic and prognostic value. Given that lncRNAs are known to have a highly cell-type-specific expression pattern, we searched for lncRNAs specifically expressed by activated T cells and at the same time in a kind of lymphoma, follicular lymphoma, where the microenvironment is known to play a critical role in the regulation of antitumor immunity. We focused on a non-coding transcript, annotated as LINC00892, which reaches extremely high expression levels following cell activation in Jurkat cells. Interestingly LINC00892 has an expression pattern resembling that of genes involved in T cell memory. Accordingly, LINC00892 is mostly expressed by the effector memory and helper CD4+ T cell sub-types but not by naïve T cells. In situ analyses of LINC00892 expression in normal lymph nodes and in follicular lymphoma biopsies show that its expression is limited to CD4+ PD1hi T cells, with a subcellular localization within the germinal center matching that of follicular helper T cells. Our analysis therefore suggests that the previously uncharacterized lncRNA LINC00892 could be a useful biomarker for the detection of CD4+ memory T cells in both normal and tumor tissues. View Full-Text
Keywords: lncRNA; LINC00892; T cell activation; PD1; T helper cells; Follicular Lymphoma lncRNA; LINC00892; T cell activation; PD1; T helper cells; Follicular Lymphoma
Show Figures

Figure 1

MDPI and ACS Style

Iaccarino, I.; Mourtada, F.; Reinke, S.; Patil, P.; Doose, G.; Monaco, G.; Hoffmann, S.; Siebert, R.; Klapper, W. LINC00892 Is an lncRNA Induced by T Cell Activation and Expressed by Follicular Lymphoma-Resident T Helper Cells. Non-Coding RNA 2022, 8, 40. https://doi.org/10.3390/ncrna8030040

AMA Style

Iaccarino I, Mourtada F, Reinke S, Patil P, Doose G, Monaco G, Hoffmann S, Siebert R, Klapper W. LINC00892 Is an lncRNA Induced by T Cell Activation and Expressed by Follicular Lymphoma-Resident T Helper Cells. Non-Coding RNA. 2022; 8(3):40. https://doi.org/10.3390/ncrna8030040

Chicago/Turabian Style

Iaccarino, Ingram, Fatme Mourtada, Sarah Reinke, Paurnima Patil, Gero Doose, Gianni Monaco, Steve Hoffmann, Reiner Siebert, and Wolfram Klapper. 2022. "LINC00892 Is an lncRNA Induced by T Cell Activation and Expressed by Follicular Lymphoma-Resident T Helper Cells" Non-Coding RNA 8, no. 3: 40. https://doi.org/10.3390/ncrna8030040

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop