Dear Colleagues,

Deciphering the functions and modes of action of noncoding RNAs (ncRNAs) constitute a major challenge in RNA biology. The questions of whether and how ncRNAs act are tightly linked to spatial parameters. ncRNAs are found in diverse, more or less structured subcellular compartments, where they can be either sequestered or acting. Some ncRNAs are associated with chromatin where they might control chromosome organization. Other ncRNAs travel within the nucleoplasm or are addressed to cytoplasmic organelles and macromolecular structures. ncRNAs can also be found in the extracellular space following their secretion through extracellular vesicles. Subcellularly localized ncRNAs and circulating extracellular ncRNAs found in body fluids might provide convenient biomarkers of diseases. Finally targeting the proper localization of ncRNA might provide new therapeutic opportunities.

In this special issue, we welcome original as well as review articles addressing:

• the mechanisms regulating ncRNA spatial distribution (from RNA motifs to interacting factors and beyond)
• the mechanisms involved in the intricate relationship between ncRNA localization and function
• the experimental approaches and strategies to investigate and modulate ncRNA sub- and extra-cellular localization.

Dr. Claire Rougeulle
Dr. Stéphan Vagner
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Non-Coding RNA is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• noncoding RNA
• subcellular localization
• chromatin
• nuclear bodies
• extracellular ncRNAs
• phase separation