Regulation and Analysis of Noncoding RNA Sub- and Extra-Cellular Localization

Dear Colleagues,

Deciphering the functions and modes of action of noncoding RNAs (ncRNAs) constitute a major challenge in RNA biology. The questions of whether and how ncRNAs act are tightly linked to spatial parameters. ncRNAs are found in diverse, more or less structured subcellular compartments, where they can be either sequestered or acting. Some ncRNAs are associated with chromatin where they might control chromosome organization. Other ncRNAs travel within the nucleoplasm or are addressed to cytoplasmic organelles and macromolecular structures. ncRNAs can also be found in the extracellular space following their secretion through extracellular vesicles. Subcellularly localized ncRNAs and circulating extracellular ncRNAs found in body fluids might provide convenient biomarkers of diseases. Finally targeting the proper localization of ncRNA might provide new therapeutic opportunities.

In this special issue, we welcome original as well as review articles addressing:

• the mechanisms regulating ncRNA spatial distribution (from RNA motifs to interacting factors and beyond)
• the mechanisms involved in the intricate relationship between ncRNA localization and function
• the experimental approaches and strategies to investigate and modulate ncRNA sub- and extra-cellular localization.

Dr. Claire Rougeulle
Dr. Stéphan Vagner
Guest Editors

Manuscript Submission Information

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