Special Issue "Regulation and Analysis of Noncoding RNA Sub- and Extra-Cellular Localization"

A special issue of Non-Coding RNA (ISSN 2311-553X).

Deadline for manuscript submissions: closed (30 May 2022) | Viewed by 903

Special Issue Editors

Dr. Claire Rougeulle
E-Mail Website
Guest Editor
Department of Epigenetics and Cell Fate, Paris Diderot University, Paris, France
Interests: long non-coding RNAs; X-inactivation; stem cells; differentiation; development; non-coding RNA evolution; epigenetics
Special Issues, Collections and Topics in MDPI journals
Dr. Stéphan Vagner
E-Mail Website
Guest Editor
Institut Curie, PSL Research University, Paris-Saclay University, CNRS UMR3348, Inserm U1278, 91405 Orsay Cedex, France
Interests: genome integrity; RNA; cancer

Special Issue Information

Dear Colleagues,

Deciphering the functions and modes of action of noncoding RNAs (ncRNAs) constitute a major challenge in RNA biology. The questions of whether and how ncRNAs act are tightly linked to spatial parameters. ncRNAs are found in diverse, more or less structured subcellular compartments, where they can be either sequestered or acting. Some ncRNAs are associated with chromatin where they might control chromosome organization. Other ncRNAs travel within the nucleoplasm or are addressed to cytoplasmic organelles and macromolecular structures. ncRNAs can also be found in the extracellular space following their secretion through extracellular vesicles. Subcellularly localized ncRNAs and circulating extracellular ncRNAs found in body fluids might provide convenient biomarkers of diseases. Finally targeting the proper localization of ncRNA might provide new therapeutic opportunities.

In this special issue, we welcome original as well as review articles addressing:

  • the mechanisms regulating ncRNA spatial distribution (from RNA motifs to interacting factors and beyond)
  • the mechanisms involved in the intricate relationship between ncRNA localization and function
  • the experimental approaches and strategies to investigate and modulate ncRNA sub- and extra-cellular localization.

Dr. Claire Rougeulle
Dr. Stéphan Vagner
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Non-Coding RNA is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • noncoding RNA
  • subcellular localization
  • chromatin
  • nuclear bodies
  • extracellular ncRNAs
  • phase separation

Published Papers (1 paper)

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Review

Review
Tumor Suppressive Effects of GAS5 in Cancer Cells
Non-Coding RNA 2022, 8(3), 39; https://doi.org/10.3390/ncrna8030039 - 28 May 2022
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Abstract
In recent years, long non-coding RNAs (lncRNAs) have been shown to play important regulatory roles in cellular processes. Growth arrests specific transcript 5 (GAS5) is a lncRNA that is highly expressed during the cell cycle arrest phase but is downregulated in actively growing [...] Read more.
In recent years, long non-coding RNAs (lncRNAs) have been shown to play important regulatory roles in cellular processes. Growth arrests specific transcript 5 (GAS5) is a lncRNA that is highly expressed during the cell cycle arrest phase but is downregulated in actively growing cells. Growth arrests specific transcript 5 was discovered to be downregulated in several cancers, primarily solid tumors, and it is known as a tumor suppressor gene that regulates cell proliferation, invasion, migration, and apoptosis via multiple molecular mechanisms. Furthermore, GAS5 polymorphism was found to affect GAS5 expression and functionality in a cell-specific manner. This review article focuses on GAS5’s tumor-suppressive effects in regulating oncogenic signaling pathways, cell cycle, apoptosis, tumor-associated genes, and treatment-resistant cells. We also discussed genetic polymorphisms of GAS5 and their association with cancer susceptibility. Full article
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