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Open AccessFeature PaperArticle

Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation

1
Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, 3-3-35 Yamate, Suita, Osaka 564-8680, Japan
2
Organization for Research and Development of Innovative Science and Technology (ORDIST), Kansai University, Suita, Osaka 564-8680, Japan
3
Research Fellow of Japan Society for the promotion of Science, Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan
*
Author to whom correspondence should be addressed.
Received: 4 October 2017 / Revised: 13 October 2017 / Accepted: 13 October 2017 / Published: 15 October 2017
(This article belongs to the Special Issue Stimuli-Responsive Gels)
We investigated the release behavior of glucagon-like peptide-1 (GLP-1) from a biodegradable injectable polymer (IP) hydrogel. This hydrogel shows temperature-responsive irreversible gelation due to the covalent bond formation through a thiol-ene reaction. In vitro sustained release of GLP-1 from an irreversible IP formulation (F(P1/D+PA40)) was observed compared with a reversible (physical gelation) IP formulation (F(P1)). Moreover, pharmaceutically active levels of GLP-1 were maintained in blood after subcutaneous injection of the irreversible IP formulation into rats. This system should be useful for the minimally invasive sustained drug release of peptide drugs and other water-soluble bioactive reagents. View Full-Text
Keywords: injectable polymers; sustained release; sol-to-gel transition; hydrogel; peptide drug delivery injectable polymers; sustained release; sol-to-gel transition; hydrogel; peptide drug delivery
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MDPI and ACS Style

Takata, K.; Takai, H.; Yoshizaki, Y.; Nagata, T.; Kawahara, K.; Yoshida, Y.; Kuzuya, A.; Ohya, Y. Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation. Gels 2017, 3, 38.

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