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Gels, Volume 10, Issue 9

September 2024 - 65 articles

Cover Story: Hydrogels are essential in tissue engineering due to their 3D structure and ability to support cellular functions, but dextran-based hydrogels lack intrinsic biological activity. This study introduces bioactive hydrogels using sequential thiol–maleimide bio-functionalization and enzyme-catalyzed crosslinking. The hydrogel network forms through the crosslinking of tyramine moieties with horseradish peroxidase (HRP) and hydrogen peroxide (H2O2), enabling tunable gelation and stiffness. Maleimide groups allow the coupling of thiol-containing bioactive molecules like RGD peptides to enhance biological activity. Human mesenchymal stem cells (hMSCs) showed over 88% viability on day 1 and 60–81% by day 14, with adipogenic differentiation observed. Hence, DexTA–Mal hydrogels offer a biocompatible, adaptable platform for tissue engineering. View this paper
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Articles (65)

  • Article
  • Open Access
7 Citations
2,400 Views
20 Pages

23 September 2024

Hybrid hydrogels with superabsorbent properties based on acrylic acid (20%), sodium alginate (0.5%) and poly(ethylene oxide) (0.1%) were obtained by electron-beam irradiation between 5 and 20 kGy, and are characterized by different physical and chemi...

  • Article
  • Open Access
4 Citations
1,921 Views
21 Pages

Development of Glycerosomal pH Triggered In Situ Gelling System to Ameliorate the Nasal Delivery of Sulpiride for Pediatric Psychosis

  • Mona M. Shahien,
  • Alia Alshammari,
  • Somaia Ibrahim,
  • Enas Haridy Ahmed,
  • Hanan Abdelmawgoud Atia,
  • Hemat A. Elariny and
  • Marwa H. Abdallah

23 September 2024

Sulpiride (Sul) is a medication that blocks dopamine D2 receptors. It is used to treat gastrointestinal disturbances and has antipsychotic effects depending on the dose given. Sulpiride is subject to P-glycoprotein efflux, resulting in limited bioava...

  • Article
  • Open Access
2 Citations
2,023 Views
11 Pages

23 September 2024

Cellulose has garnered attention in the textile industry, but it exhibits limitations in applications that require high strength and modulus. In this study, regenerated cellulose fiber with enhanced mechanical properties was fabricated from a gel-lik...

  • Article
  • Open Access
2 Citations
1,619 Views
13 Pages

Antibacterial Properties of Grape Seed Extract-Enriched Cellulose Hydrogels for Potential Dental Application: In Vitro Assay, Cytocompatibility, and Biocompatibility

  • Karla Lizette Tovar-Carrillo,
  • Lizett Trujillo-Morales,
  • Juan Carlos Cuevas-González,
  • Judith Virginia Ríos-Arana,
  • León Francisco Espinosa-Cristobal and
  • Erasto Armando Zaragoza-Contreras

23 September 2024

Hydrogels elaborated from Dasylirion spp. and enriched with grape seed extract (GSE) were investigated for tentative use in dental treatment. Cellulose-GSE hydrogels were elaborated with varying GSE contents from 10 to 50 wt%. The mechanical and phys...

  • Article
  • Open Access
7 Citations
2,014 Views
15 Pages

Composite Polysaccharide Hydrogel Loaded with Scutellaria baicalensis Extract for Diabetic Wound Treatment

  • Yumeng Zhu,
  • Fangyan Li,
  • Shuo Wang,
  • Hongmei Shi,
  • Minqian Zhao,
  • Shaohong You,
  • Sibo Su and
  • Gang Cheng

23 September 2024

Diabetic wounds present significant burdens to both patients and the healthcare system due to their prolonged inflammatory phase and adverse microenvironment. Traditional Chinese medicine (TCM), particularly Scutellaria baicalensis extract (SE), has...

  • Article
  • Open Access
2 Citations
2,275 Views
12 Pages

23 September 2024

Recently, cellulose and other biomass nanofibers (NFs) have been increasingly utilized in the design of sustainable materials for environmental, biomedical, and other applications. However, the past literature lacks a comparison of the macromolecular...

  • Article
  • Open Access
2 Citations
1,986 Views
19 Pages

Anti-Biofouling Polyzwitterion–Poly(amidoxime) Composite Hydrogel for Highly Enhanced Uranium Extraction from Seawater

  • Lang Yang,
  • Ye Sun,
  • Yue Sun,
  • Jiawen Wang,
  • Lin Chen,
  • Xueliang Feng,
  • Jinggang Wang,
  • Ning Wang,
  • Dong Zhang and
  • Chunxin Ma

22 September 2024

Amidoxime-functionalized hydrogels are one of most promising adsorbents for high-efficiency uranium (U) extraction from seawater, but bioadhesion on their surface seriously decreases their adsorption efficiency and largely shortens their service life...

  • Article
  • Open Access
2,040 Views
14 Pages

A pH-Responsive Hydrogel for the Oral Delivery of Ursolic Acid: A Pentacyclic Triterpenoid Phytochemical

  • Carlos D. Gutierrez,
  • Rosana L. Aranzábal,
  • Ana M. Lechuga,
  • Carlos A. Serrano,
  • Flor Meza,
  • Carlos Elvira,
  • Alberto Gallardo and
  • Michael A. Ludeña

22 September 2024

In this study, poly(HEMA-PEGxMEM-IA) hydrogels were prepared by radical copolymerization of poly(ethylene glycol) methyl ether methacrylate (PEGxMEM), 2-hydroxyethyl methacrylate (HEMA), and itaconic acid (IA). The reaction was carried out in ethanol...

  • Article
  • Open Access
1 Citations
2,124 Views
18 Pages

In Vitro Culture of Human Dermal Fibroblasts on Novel Electrospun Polylactic Acid Fiber Scaffolds Loaded with Encapsulated Polyepicatechin Physical Gels

  • Eliza Miranda-Buendia,
  • Gertrudis H. González-Gómez,
  • Alfredo Maciel-Cerda and
  • Maykel González-Torres

20 September 2024

Polyepicatechin (PEC) in a hydrogel has previously shown promise in enhancing physiological properties and scaffold preparation. However, it remains unclear whether PEC-based fibers can be applied in skin tissue engineering (STE). This study aimed to...

  • Article
  • Open Access
3 Citations
2,230 Views
18 Pages

20 September 2024

Objectives: The study addresses the challenge of cross-infection in dentistry, focusing on improving disinfection protocols for dental hydrocolloid gel materials. This research aimed to incorporate chlorhexidine, natural plant extracts, and green-syn...

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Gels - ISSN 2310-2861