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Journal of Fungi, Volume 8, Issue 5

May 2022 - 132 articles

Cover Story: Yeasts need a lot of potassium to grow. The main K+ uptake system Trk1 has been shown to exist in low- or high-affinity modes according to the K+ availability, but when and how the affinity changes remains unknown. Here, we characterize the Trk1 kinetic parameters under various conditions and find that Trk1’s KT and Vmax change gradually. This gliding adjustment is rapid and controlled by changes in intracellular potassium content and membrane potential. The introduction of mutations to four specific structural segments (P-helices) of Trk1 showed the importance of two P-helices for the transporter’s transition to a high-affinity state, as well as the importance of the other two for proper Trk1 folding and activity at the plasma membrane. View this paper
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Articles (132)

  • Article
  • Open Access
3 Citations
3,211 Views
17 Pages

Secretome Profiling by Proteogenomic Analysis Shows Species-Specific, Temperature-Dependent, and Putative Virulence Proteins of Pythium insidiosum

  • Theerapong Krajaejun,
  • Thidarat Rujirawat,
  • Tassanee Lohnoo,
  • Wanta Yingyong,
  • Pattarana Sae-Chew,
  • Onrapak Reamtong,
  • Weerayuth Kittichotirat and
  • Preecha Patumcharoenpol

20 May 2022

In contrast to most pathogenic oomycetes, which infect plants, Pythium insidiosum infects both humans and animals, causing a difficult-to-treat condition called pythiosis. Most patients undergo surgical removal of an affected organ, and advanced case...

  • Article
  • Open Access
26 Citations
3,913 Views
15 Pages

Sclerotinia sclerotiorum SsCut1 Modulates Virulence and Cutinase Activity

  • Yingdi Gong,
  • Yanping Fu,
  • Jiatao Xie,
  • Bo Li,
  • Tao Chen,
  • Yang Lin,
  • Weidong Chen,
  • Daohong Jiang and
  • Jiasen Cheng

20 May 2022

The plant cuticle is one of the protective layers of the external surface of plant tissues. Plants use the cuticle layer to reduce water loss and resist pathogen infection. Fungi release cell wall-degrading enzymes to destroy the epidermis of plants...

  • Article
  • Open Access
4 Citations
2,749 Views
13 Pages

Synergistic In Vitro Interaction of Isavuconazole and Isoquercitrin against Candida glabrata

  • Petra V. Schwarz,
  • Ilya Nikolskiy,
  • Eric Dannaoui,
  • Frank Sommer,
  • Gert Bange and
  • Patrick Schwarz

20 May 2022

In vitro interactions of broad-spectrum azole isavuconazole with flavonoid isoquercitrin were evaluated by a broth microdilution checkerboard technique based on the European Committee on Antimicrobial Susceptibility Testing (EUCAST) reference methodo...

  • Article
  • Open Access
12 Citations
4,461 Views
12 Pages

Ustilago maydis Metabolic Characterization and Growth Quantification with a Genome-Scale Metabolic Model

  • Ulf W. Liebal,
  • Lena Ullmann,
  • Christian Lieven,
  • Philipp Kohl,
  • Daniel Wibberg,
  • Thiemo Zambanini and
  • Lars M. Blank

20 May 2022

Ustilago maydis is an important plant pathogen that causes corn smut disease and serves as an effective biotechnological production host. The lack of a comprehensive metabolic overview hinders a full understanding of the organism’s environmenta...

  • Article
  • Open Access
15 Citations
3,604 Views
18 Pages

18 May 2022

Tropospheric ozone and nitrogen deposition are two major environmental pollutants. A great deal of research has focused on the negative impacts of elevated O3 and the complementary effect of soil N addition on the physiological properties of trees. H...

  • Article
  • Open Access
3 Citations
4,475 Views
21 Pages

Heme Oxygenase-1 (HMX1) Loss of Function Increases the In-Host Fitness of the Saccharomyces ‘boulardii’ Probiotic Yeast in a Mouse Fungemia Model

  • Alexandra Imre,
  • Renátó Kovács,
  • Zoltán Tóth,
  • László Majoros,
  • Zsigmond Benkő,
  • Walter P. Pfliegler and
  • István Pócsi

18 May 2022

The use of yeast-containing probiotics is on the rise; however, these products occasionally cause fungal infections and possibly even fungemia among susceptible probiotic-treated patients. The incidence of such cases is probably underestimated, which...

  • Article
  • Open Access
27 Citations
3,188 Views
21 Pages

Encephalartos villosus Lem. Displays a Strong In Vivo and In Vitro Antifungal Potential against Candida glabrata Clinical Isolates

  • Moneerah J. Alqahtani,
  • Engy Elekhnawy,
  • Walaa A. Negm,
  • Sebaey Mahgoub and
  • Ismail A. Hussein

18 May 2022

Recently, Candida glabrata has been recognized as one of the most common fungal species that is highly associated with invasive candidiasis. Its spread could be attributed to its increasing resistance to antifungal drugs. Thus, there is a high need f...

  • Article
  • Open Access
10 Citations
4,402 Views
20 Pages

Taxonomy, Phylogenetic and Ancestral Area Reconstruction in Phyllachora, with Four Novel Species from Northwestern China

  • Jin-Chen Li,
  • Hai-Xia Wu,
  • Yuying Li,
  • Xin-Hao Li,
  • Jia-Yu Song,
  • Nakarin Suwannarach and
  • Nalin N. Wijayawardene

18 May 2022

The members of Phyllachora are biotrophic, obligate plant parasitic fungi featuring a high degree of host specificity. This genus also features a high degree of species richness and worldwide distribution. In this study, four species occurring on lea...

  • Article
  • Open Access
24 Citations
3,775 Views
17 Pages

Metabolomics Analysis and Antioxidant Potential of Endophytic Diaporthe fraxini ED2 Grown in Different Culture Media

  • Wen-Nee Tan,
  • Kashvintha Nagarajan,
  • Vuanghao Lim,
  • Juzaili Azizi,
  • Kooi-Yeong Khaw,
  • Woei-Yenn Tong,
  • Chean-Ring Leong and
  • Nelson Jeng-Yeou Chear

18 May 2022

Endophytic fungi are a promising source of bioactive metabolites with a wide range of pharmacological activities. In the present study, MS-based metabolomics was conducted to study the metabolomes variations of endophytic Diaporthe fraxini ED2 grown...

  • Article
  • Open Access
11 Citations
4,628 Views
14 Pages

Stemphylium lycopersici Nep1-like Protein (NLP) Is a Key Virulence Factor in Tomato Gray Leaf Spot Disease

  • Jiajie Lian,
  • Hongyu Han,
  • Xizhan Chen,
  • Qian Chen,
  • Jiuhai Zhao and
  • Chuanyou Li

18 May 2022

The fungus Stemphylium lycopersici (S. lycopersici) is an economically important plant pathogen that causes grey leaf spot disease in tomato. However, functional genomic studies in S. lycopersici are lacking, and the factors influencing its pathogeni...

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J. Fungi - ISSN 2309-608X