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SUMOylation in Human Pathogenic Fungi: Role in Physiology and Virulence

1
Laboratory of Fungal Pathogenesis, Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500039, Telangana, India
2
Graduate studies, Regional Centre for Biotechnology, Faridabad 121001, Haryana, India
3
Graduate studies, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India
*
Author to whom correspondence should be addressed.
J. Fungi 2020, 6(1), 32; https://doi.org/10.3390/jof6010032
Received: 14 February 2020 / Revised: 2 March 2020 / Accepted: 3 March 2020 / Published: 4 March 2020
(This article belongs to the Special Issue Epigenetic Regulation of Fungal Virulence)
The small ubiquitin-related modifier (SUMO) protein is an important component of the post-translational protein modification systems in eukaryotic cells. It is known to modify hundreds of proteins involved in diverse cellular processes, ranging from nuclear pore dynamics to signal transduction pathways. Owing to its reversible nature, the SUMO-conjugation of proteins (SUMOylation) holds a prominent place among mechanisms that regulate the functions of a wide array of cellular proteins. The dysfunctional SUMOylation system has been associated with many human diseases, including neurodegenerative and autoimmune disorders. Furthermore, the non-pathogenic yeast Saccharomyces cerevisiae has served as an excellent model to advance our understanding of enzymes involved in SUMOylation and proteins modified by SUMOylation. Taking advantage of the tools and knowledge obtained from the S. cerevisiae SUMOylation system, research on fungal SUMOylation is beginning to gather pace, and new insights into the role of SUMOylation in the pathobiology of medically important fungi are emerging. Here, we summarize the known information on components of the SUMOylation machinery, and consequences of overexpression or deletion of these components in the human pathogenic fungi, with major focus on two prevalent Candida bloodstream pathogens, C. albicans and C. glabrata. Additionally, we have identified SUMOylation components, through in silico analysis, in four medically relevant fungi, and compared their sequence similarity with S. cerevisiae counterparts. SUMOylation modulates the virulence of C. albicans and C. glabrata, while it is required for conidia production in Aspergillus nidulans and A. flavus. In addition to highlighting these recent developments, we discuss how SUMOylation fine tunes the expression of virulence factors, and influences survival of fungal cells under diverse stresses in vitro and in the mammalian host. View Full-Text
Keywords: small ubiquitin-like modifier (SUMO); human pathogenic fungi; Candida glabrata; Candida albicans; SUMO-specific proteases and ligases; virulence; stress survival small ubiquitin-like modifier (SUMO); human pathogenic fungi; Candida glabrata; Candida albicans; SUMO-specific proteases and ligases; virulence; stress survival
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MDPI and ACS Style

Sahu, M.S.; Patra, S.; Kumar, K.; Kaur, R. SUMOylation in Human Pathogenic Fungi: Role in Physiology and Virulence. J. Fungi 2020, 6, 32.

AMA Style

Sahu MS, Patra S, Kumar K, Kaur R. SUMOylation in Human Pathogenic Fungi: Role in Physiology and Virulence. Journal of Fungi. 2020; 6(1):32.

Chicago/Turabian Style

Sahu, Mahima S.; Patra, Sandip; Kumar, Kundan; Kaur, Rupinder. 2020. "SUMOylation in Human Pathogenic Fungi: Role in Physiology and Virulence" J. Fungi 6, no. 1: 32.

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