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Special Issue "Epigenetic Regulation of Fungal Virulence"
A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Genomics, Genetics and Molecular Biology".
Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 12498
Special Issue Editors
Interests: Candidiasis; antifungal drug resistance; Chromatin; epigenetics; host-fungal interactions; fungal pathogenesis
Interests: host-fungal interactions; innate/adaptive antifungal immunity; immune signaling; fungal pathogens; Candida spp.
Special Issue Information
Conrad Waddington conied the term “epigenetics” in 1942 to explain the presence of other mechanisms of inheritance of certain traits in addition to genetics. Since then, it has been shown that epigenetic changes such as chromatin remodeling involving histone acetylation and methylation play a critical role in the regulation of gene expression. New evidence indicates that chromatin structure impacts fungal virulence and/or pathogen fitness in the host. Furthermore, chromatin remodeling and assembly pathways regulate the dynamic interplay with host immune surveillance, facilitate immune evasion, and drive antifungal drug resistance.
During host-pathogen interactions, the host immune system often triggers epigenetic changes in the pathogen, which in turn activate transcriptional networks to coordinate an adaptive response. Conversely, it has also been noted that certain pathogens manipulate the post-translational modification of host proteins to promote their replication and to evade the host immune system.
To continue a discussion on the spirit of epigenetics and of the recent exciting discoveries in the field, we would like to dedicate a Special Issue to “Epigenetic regulation of fungal virulence.” Research articles that include, but are not limited to, current and emerging therapies targeting chromatin, phenotypes of fungal epigenetic (lysine acetyltransferases (KATs)/lysine deacetylases (KDACs) and methyltransferases) regulatory mutants, inhibitors of KATs/KDACs and methyltransferases, and antifungal drugs and their mechanism(s) of action will be of special interest.
Dr. Neeraj Chauhan
Prof. Dr. Karl Kuchler
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.