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Epigenetic Regulation of Organ Regeneration in Zebrafish

Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100871, China
Authors to whom correspondence should be addressed.
J. Cardiovasc. Dev. Dis. 2018, 5(4), 57;
Received: 18 November 2018 / Revised: 11 December 2018 / Accepted: 12 December 2018 / Published: 14 December 2018
(This article belongs to the Special Issue Cardiac Regeneration in Non-Mammalian Vertebrates)
The zebrafish is broadly used for investigating de novo organ regeneration, because of its strong regenerative potential. Over the past two decades of intense study, significant advances have been made in identifying both the regenerative cell sources and molecular signaling pathways in a variety of organs in adult zebrafish. Epigenetic regulation has gradually moved into the center-stage of this research area, aided by comprehensive work demonstrating that DNA methylation, histone modifications, chromatin remodeling complexes, and microRNAs are essential for organ regeneration. Here, we present a brief review of how these epigenetic components are induced upon injury, and how they are involved in sophisticated organ regeneration. In addition, we highlight several prospective research directions and their potential implications for regenerative medicine. View Full-Text
Keywords: regeneration; zebrafish; DNA methylation; histone modification; SWI/SNF complex; miRNA regeneration; zebrafish; DNA methylation; histone modification; SWI/SNF complex; miRNA
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Zhu, X.; Xiao, C.; Xiong, J.-W. Epigenetic Regulation of Organ Regeneration in Zebrafish. J. Cardiovasc. Dev. Dis. 2018, 5, 57.

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