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Journal of Cardiovascular Development and Disease, Volume 2, Issue 1

March 2015 - 3 articles

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Articles (3)

  • Article
  • Open Access
32 Citations
16,463 Views
14 Pages

Evidence of Aortopathy in Mice with Haploinsufficiency of Notch1 in Nos3-Null Background

  • Sara N. Koenig,
  • Kevin M. Bosse,
  • Holly A. Nadorlik,
  • Brenda Lilly and
  • Vidu Garg

Thoracic aortic aneurysms (TAA) are a significant cause of morbidity and mortality in humans. While the exact etiology is unknown, genetic factors play an important role. Mutations in NOTCH1 have been linked to bicuspid aortic valve (BAV) and aortopa...

  • Review
  • Open Access
36 Citations
10,833 Views
15 Pages

Many of the major discoveries in the fields of genetics and developmental biology have been made using the fruit fly, Drosophila melanogaster. With regard to heart development, the conserved network of core cardiac transcription factors that underlie...

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J. Cardiovasc. Dev. Dis. - ISSN 2308-3425Creative Common CC BY license