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Journal of Cardiovascular Development and Disease, Volume 10, Issue 12

2023 December - 29 articles

Cover Story: In recent decades, new techniques have been developed that provide accurate information about necrotic myocardial tissue following acute myocardial infarction. Cardiac magnetic resonance imaging (CMR) has emerged as a tool for the precise estimation of the development of infarct size when measured serially. There is a growing body of evidence that suggests coronary collaterals may play an important role in myocardial salvage and cardiac function. What is the relationship between infarct size measured using serial CMR and well-developed coronary collaterals? Could stratifying patients in acute situations according to the Cohen–Rentrop score prove beneficial? View this paper
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Articles (29)

  • Correction
  • Open Access
1,712 Views
2 Pages

Correction: Hlavicka et al. Long-Term Outcomes after Aortic Valve and Root Replacement in a Very High-Risk Population. J. Cardiovasc. Dev. Dis. 2022, 9, 197

  • Jan Hlavicka,
  • Kiril Antonov,
  • Razan Salem,
  • Florian Hecker,
  • Spiros Marinos,
  • Medhat Radwan,
  • Fabian Emrich,
  • Arnaud Van Linden,
  • Anton Moritz and
  • Tomas Holubec
  • + 1 author

The authors would like to make the following corrections to the published paper [...]

  • Review
  • Open Access
3 Citations
4,604 Views
10 Pages

Revolutionizing the Management of Large-Core Ischaemic Strokes: Decoding the Success of Endovascular Therapy in the Recent Stroke Trials

  • Gareth Zigui Lim,
  • Jonathan Yexian Lai,
  • Christopher Ying Hao Seet,
  • Carol Huilian Tham,
  • Narayanaswamy Venketasubramanian,
  • Benjamin Yong Qiang Tan,
  • Mingxue Jing,
  • Joshua Yee Peng Yeo,
  • May Zin Myint and
  • Leonard Leong Litt Yeo
  • + 7 authors

Endovascular therapy (EVT) has revolutionized the management of acute ischaemic strokes with large vessel occlusion, with emerging evidence suggesting its benefit also in large infarct core volume strokes. In the last two years, four randomised contr...

  • Systematic Review
  • Open Access
11 Citations
5,096 Views
15 Pages

Pulmonary Vasodilator Therapy in Severe Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease (Severe PH-COPD): A Systematic Review and Meta-Analysis

  • Ahmed Elkhapery,
  • M. Bakri Hammami,
  • Roxana Sulica,
  • Hemanth Boppana,
  • Zeinab Abdalla,
  • Charoo Iyer,
  • Hazem Taifour,
  • Chengu Niu and
  • Himanshu Deshwal

Background: Chronic obstructive pulmonary disease-associated pulmonary hypertension (PH-COPD) results in a significant impact on symptoms, quality of life, and survival. There is scant and conflicting evidence about the use of pulmonary hypertension...

  • Article
  • Open Access
3 Citations
2,785 Views
9 Pages

Perinatal Stressors and Consequences for Neonates with Critical Congenital Heart Disease

  • Christina Ronai,
  • Isabel Katlaps,
  • Amanda Kim,
  • Amy M. Valent,
  • Kent L. Thornburg and
  • Erin Madriago

Introduction: The prenatal diagnosis of congenital heart disease (CHD) is a traumatic event that can cause expectant parents to experience anxiety, depression, and toxic stress. Prenatal exposure to stress may impact neonatal postoperative outcomes....

  • Article
  • Open Access
1 Citations
3,964 Views
11 Pages

Embolization of Perforated Coronary Artery with a Fragment of Balloon Catheter (Cut Balloon Technique)—Multicenter Study

  • Grzegorz Sobieszek,
  • Bartosz Zięba,
  • Wojciech Dworzański,
  • Rafał Celiński,
  • Umberto Barbero and
  • Maksymilian P. Opolski

Background: Iatrogenic distal coronary artery perforation can be a life-threatening complication. While there are different dedicated devices for the embolization of distal perforations, there are scarce data about the embolization using the fragment...

  • Review
  • Open Access
14 Citations
8,453 Views
21 Pages

Genetics in Ischemic Stroke: Current Perspectives and Future Directions

  • Ka Zhang,
  • Shaun S. E. Loong,
  • Linus Z. H. Yuen,
  • Narayanaswamy Venketasubramanian,
  • Hui-Lin Chin,
  • Poh San Lai and
  • Benjamin Y. Q. Tan

Ischemic stroke is a heterogeneous condition influenced by a combination of genetic and environmental factors. Recent advancements have explored genetics in relation to various aspects of ischemic stroke, including the alteration of individual stroke...

  • Review
  • Open Access
5 Citations
3,107 Views
13 Pages

Drosophila as a Model to Understand Second Heart Field Development

  • Cayleen Bileckyj,
  • Brenna Blotz and
  • Richard M. Cripps

The genetic model system Drosophila has contributed fundamentally to our understanding of mammalian heart specification, development, and congenital heart disease. The relatively simple Drosophila heart is a linear muscular tube that is specified and...

  • Review
  • Open Access
12 Citations
4,304 Views
15 Pages

Biological Age in Congenital Heart Disease—Exploring the Ticking Clock

  • Tijs K. Tournoy,
  • Philip Moons,
  • Bo Daelman and
  • Julie De Backer

Over the past 50 years, there has been a major shift in age distribution of patients with congenital heart disease (CHD) thanks to significant advancements in medical and surgical treatment. Patients with CHD are, however, never cured and face unique...

  • Article
  • Open Access
5 Citations
2,896 Views
14 Pages

Association between Psychiatric Disorders and the Incidence of Heart Failure in Women

  • Daniel Antwi-Amoabeng,
  • Vijay Neelam,
  • Mark Bilinyi Ulanja,
  • Bryce David Beutler,
  • Tokunbo David Gbadebo and
  • Prasanna Sugathan

Background: Depression and anxiety occur more frequently in women and are associated with an increased risk of cardiovascular disease. Objectives: Data on the association between these psychiatric conditions and the incidence of acute heart failure (...

  • Article
  • Open Access
20 Citations
5,515 Views
18 Pages

The Effects of Interphase and Interpulse Delays and Pulse Widths on Induced Muscle Contractions, Pain and Therapeutic Efficacy in Electroporation-Based Therapies

  • Aleksandra Cvetkoska,
  • Alenka Maček-Lebar,
  • Tamara Polajžer,
  • Matej Reberšek,
  • Weston Upchurch,
  • Paul A. Iaizzo,
  • Daniel C. Sigg and
  • Damijan Miklavčič

Electroporation is used in medicine for drug and gene delivery, and as a nonthermal ablation method in tumor treatment and cardiac ablation. Electroporation involves delivering high-voltage electric pulses to target tissue; however, this can cause ef...

  • Review
  • Open Access
11 Citations
5,085 Views
19 Pages

Trastuzumab is the primary treatment for all stages of HER2-overexpressing breast cancer in patients. Though discovered over 20 years ago, trastuzumab-induced cardiotoxicity (TIC) remains a research topic in cardio-oncology. This review explores the...

  • Review
  • Open Access
7 Citations
4,762 Views
11 Pages

Biomarkers for Heart Failure Prediction and Prevention

  • Prasanti Alekhya Kotta,
  • Vijay Nambi and
  • Biykem Bozkurt

Heart failure (HF) is a global pandemic affecting over 64 million people worldwide. Its prevalence is on an upward trajectory, with associated increasing healthcare expenditure. Organizations including the American College of Cardiology (ACC) and the...

  • Article
  • Open Access
2 Citations
2,541 Views
13 Pages

Intravenous Cavutilide for Pharmacological Conversion of Paroxysmal and Persistent Atrial Fibrillation in Patients with Heart Failure

  • Maria M. Beliaeva,
  • Khava M. Dzaurova,
  • Yulia A. Yuricheva,
  • Peter S. Novikov,
  • Nikolay Yu. Mironov,
  • Gennady S. Tarasovskiy,
  • Maksim A. Zelberg,
  • Sergey F. Sokolov and
  • Sergey P. Golitsyn

This work aimed to study the efficacy and safety of the class III antiarrhythmic agent cavutilide (Niferidil, Refralon) for pharmacological cardioversion in patients with paroxysmal and persistent atrial fibrillation (AF) and heart failure (HF). Meth...

  • Perspective
  • Open Access
4 Citations
2,650 Views
10 Pages

The healthcare sector generates approximately 30% of all the world’s data volume, mostly for record keeping, compliance and regulatory requirements, and patient care. Healthcare data often exist in silos or on different systems and platforms du...

  • Review
  • Open Access
12 Citations
5,333 Views
54 Pages

Deep Learning Paradigm and Its Bias for Coronary Artery Wall Segmentation in Intravascular Ultrasound Scans: A Closer Look

  • Vandana Kumari,
  • Naresh Kumar,
  • Sampath Kumar K,
  • Ashish Kumar,
  • Sanagala S. Skandha,
  • Sanjay Saxena,
  • Narendra N. Khanna,
  • John R. Laird,
  • Narpinder Singh and
  • Jasjit S. Suri
  • + 3 authors

Background and Motivation: Coronary artery disease (CAD) has the highest mortality rate; therefore, its diagnosis is vital. Intravascular ultrasound (IVUS) is a high-resolution imaging solution that can image coronary arteries, but the diagnosis soft...

  • Review
  • Open Access
6 Citations
6,626 Views
14 Pages

Monoclonal Gammopathy of Undetermined Cardiovascular Significance; Current Evidence and Novel Insights

  • Anastasios Tentolouris,
  • Ioannis Ntanasis-Stathopoulos,
  • Maria Gavriatopoulou,
  • Ioanna Andreadou and
  • Evangelos Terpos

Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant condition characterized by the presence of low levels of a monoclonal protein in the serum and a low percentage of clonal plasma cells in the bone marrow. MGUS may progress t...

  • Article
  • Open Access
5 Citations
3,240 Views
15 Pages

Hippo Signaling Mediates TGFβ-Dependent Transcriptional Inputs in Cardiac Cushion Mesenchymal Cells to Regulate Extracellular Matrix Remodeling

  • Mrinmay Chakrabarti,
  • Ahad Chattha,
  • Abhijith Nair,
  • Kai Jiao,
  • Jay D. Potts,
  • Lianming Wang,
  • Scotty Branch,
  • Shea Harrelson,
  • Saeed Khan and
  • Mohamad Azhar

The transforming growth factor beta (TGFβ) and Hippo signaling pathways are evolutionarily conserved pathways that play a critical role in cardiac fibroblasts during embryonic development, tissue repair, and fibrosis. TGFβ signaling and Hip...

  • Article
  • Open Access
10 Citations
2,782 Views
15 Pages

Objectives: To assess whether competing risks help explain why regions with initially high serum cholesterol have higher mortality from coronary heart disease (CHD) and lower mortality from stroke and other major heart diseases, while the reverse is...

  • Article
  • Open Access
6 Citations
3,669 Views
12 Pages

Virtual Reality for Patient Education about Hypertension: A Randomized Pilot Study

  • Bogna Jiravska Godula,
  • Otakar Jiravsky,
  • Gabriela Matheislova,
  • Veronika Kuriskova,
  • Alena Valkova,
  • Kristina Puskasova,
  • Martin Dokoupil,
  • Veronika Dvorakova,
  • Arber Prifti and
  • Roman Miklik
  • + 5 authors

Background: Hypertension challenges arise in part from poor adherence due to inadequate patient education. VR offers immersive learning to improve hypertension knowledge. Objective: To compare VR education with traditional verbal education to improve...

  • Review
  • Open Access
16 Citations
13,684 Views
13 Pages

Exercise-Induced Blood Pressure Dynamics: Insights from the General Population and the Athletic Cohort

  • Petra Pesova,
  • Bogna Jiravska Godula,
  • Otakar Jiravsky,
  • Libor Jelinek,
  • Marketa Sovova,
  • Katarina Moravcova,
  • Jaromir Ozana,
  • Libor Gajdusek,
  • Roman Miklik and
  • Eliska Sovova
  • + 2 authors

Blood pressure (BP) dynamics during graded exercise testing provide important insights into cardiovascular health, particularly in athletes. These measurements, taken during intense physical exertion, complement and often enhance our understanding be...

  • Article
  • Open Access
7 Citations
4,498 Views
18 Pages

Males and females differ in the basic anatomy and physiology of the heart. Sex differences are evident in cardiac repolarization in humans; women have longer corrected QT and JT intervals. However, the molecular mechanisms that lead to these differen...

  • Review
  • Open Access
3 Citations
3,544 Views
11 Pages

SGLT2 Inhibitors in Long COVID Syndrome: Is There a Potential Role?

  • Paul Zimmermann,
  • Harald Sourij,
  • Felix Aberer,
  • Sian Rilstone,
  • Janis Schierbauer and
  • Othmar Moser

The coronavirus disease (COVID)-19 has turned into a pandemic causing a global public health crisis. While acute COVID-19 mainly affects the respiratory system and can cause acute respiratory distress syndrome, an association with persistent inflamma...

  • Systematic Review
  • Open Access
4 Citations
3,418 Views
11 Pages

Objective: To conduct a systematic review to determine if there are exercise mobile applications (apps) that can produce evidence-based, individualized exercise plans. Materials and Methods: We searched the Apple Store and Google Play for exercise ap...

  • Review
  • Open Access
6 Citations
4,544 Views
10 Pages

The Transcatheter Closure of Patent Ductus Arteriosus in Extremely Low-Birth-Weight Infants: Technique and Results

  • Alban-Elouen Baruteau,
  • Alain Fraisse,
  • Gianfranco Butera and
  • Carles Bautista-Rodriguez

Persistent patent ductus arteriosus is a very common condition in preterm infants. Although there is no management agreed by consensus, despite numerous randomized controlled trials, hemodynamically significant patent ductus arteriosus increases morb...

  • Article
  • Open Access
3 Citations
5,968 Views
10 Pages

Efficacy and Safety of Isoprenaline during Unstable Third-Degree Atrioventricular Block

  • Manuel De Lazzari,
  • Nicolò Martini,
  • Federico Migliore,
  • Filippo Donato,
  • Luciano Babuin,
  • Giuseppe Tarantini,
  • Martina Perazzolo Marra,
  • Luisa Cacciavillani,
  • Emanuele Bertaglia and
  • Alessandro Zorzi
  • + 4 authors

Unstable and symptomatic complete atrioventricular block represents a potentially fatal condition that requires prompt therapy while waiting for definitive pacemaker implantation. Although transcutaneous pacing is included in acute management, it cou...

  • Article
  • Open Access
2 Citations
2,881 Views
10 Pages

Reference Values for Inward Displacement in the Normal Left Ventricle: A Novel Method of Regional Left Ventricular Function Assessment

  • Romy R. M. J. J. Hegeman,
  • Sean McManus,
  • Attila Tóth,
  • Ricardo Ladeiras-Lopes,
  • Pieter Kitslaar,
  • Viet Bui,
  • Kayleigh Dukker,
  • Serge C. Harb,
  • Martin J. Swaans and
  • Rishi Puri
  • + 2 authors

Background: Regional functional left ventricular (LV) assessment using current imaging techniques remains limited. Inward displacement (InD) has been developed as a novel technique to assess regional LV function via measurement of the regional displa...

  • Article
  • Open Access
3 Citations
2,961 Views
10 Pages

Association of Coronary Collaterals and Myocardial Salvage Measured by Serial Cardiac Magnetic Resonance Imaging after Acute Myocardial Infarction

  • Jan Pec,
  • Stefan Buchner,
  • Michael Wester,
  • Kurt Debl,
  • Okka W. Hamer,
  • Florian Poschenrieder,
  • Lars S. Maier,
  • Michael Arzt and
  • Stefan Stadler

Background: Coronary collateral flow in angiography has been linked with lower mortality rates in patients with coronary artery disease. However, the relevance of the underlying mechanism is sparse. Therefore, we tested the hypothesis that in patient...

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J. Cardiovasc. Dev. Dis. - ISSN 2308-3425