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Urinalysis and Urinary GGT-to-Urinary Creatinine Ratio in Dogs with Acute Pancreatitis

Department of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, 56121 Pisa, Italy
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Vet. Sci. 2019, 6(1), 27; https://doi.org/10.3390/vetsci6010027
Received: 4 December 2018 / Revised: 28 February 2019 / Accepted: 12 March 2019 / Published: 13 March 2019
(This article belongs to the Special Issue Italian Society of the Veterinary Sciences SISVet 2018)
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Abstract

In acute pancreatitis (AP), kidney injury (KI) can occur. Urinalysis and some urinary biomarkers have been proposed as prognostic tools in human AP. The aim of the study was to evaluate urinalysis and urinary GGT-to-urinary creatinine (uGGT/uCr) in canine AP and their association with possible outcomes. AP diagnosis was based on clinical and laboratory parameters, abnormal SNAP® cPL™ test and compatible imaging. Urinary KI (uKI) was defined if dogs had urinary casts and/or proteinuria. Dogs (n = 70) were divided in survivors and non-survivors according to the 15-day outcome. Data were analyzed using statistical software. Seventy dogs were retrospectively included, of which 24 dogs (34%) died. uKI was detected in 36 dogs (37%) which was associated with mortality (p = 0.01, Odds ratio (OR) 3.9, 95% CI 1.3–11.56). Non-survivors showed higher dipstick bilirubin levels than survivors (p = 0.0022). By excluding active sediments, urine protein-to-creatinine ratio (UPC) ≥2 was associated with mortality (p = 0.001, OR 47.5, 95% CI 4–571.9). The uGGT/uCr was available in 40 dogs, although no association of this factor with any outcome was found. The UPC ≥2 can be a negative prognostic factor in canine AP and further studies on uGGT/uCr are warranted. View Full-Text
Keywords: urinalysis; dog; acute pancreatitis; kidney injury; urinary GGT-to-creatinine ratio; prognosis urinalysis; dog; acute pancreatitis; kidney injury; urinary GGT-to-creatinine ratio; prognosis
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Gori, E.; Pierini, A.; Lippi, I.; Boffa, N.; Perondi, F.; Marchetti, V. Urinalysis and Urinary GGT-to-Urinary Creatinine Ratio in Dogs with Acute Pancreatitis. Vet. Sci. 2019, 6, 27.

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