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Clinical and Basic Studies on Therapeutic Efficacy of Herbal Medicines against Mycobacterial Infections

1
Department of Basic Medical Science for Nursing, Department of Primary Education, Yasuda Women’s University, Hiroshima 731-0153, Japan
2
Department of Microbiology and Immunology, Shimane University School of Medicine, Izumo 693-8501, Japan
3
Department of Pharmaceutical Sciences, International University of Health and Welfare, Otawara 324-8501, Japan
4
Department of Nutritional Sciences, Yasuda Women’s University, Hiroshima 731-0153, Japan
5
Department of Community Medicine Management, Shimane University School of Medicine, Izumo 693-8501, Japan
*
Author to whom correspondence should be addressed.
Medicines 2019, 6(2), 67; https://doi.org/10.3390/medicines6020067
Received: 14 May 2019 / Revised: 13 June 2019 / Accepted: 14 June 2019 / Published: 19 June 2019
(This article belongs to the Special Issue Natural Compounds as Potential Antibacterial Agents)
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PDF [287 KB, uploaded 19 June 2019]

Abstract

The high incidence of tuberculosis (TB) in developing countries, the resurgence of TB in industrialized countries, and the worldwide increase in the prevalence of Mycobacterium avium complex infections are important global health concerns. However, the development of novel antimycobacterial drugs is currently making very slow progress. Therefore, it is considered that devising improved administration protocols for clinical treatment against intractable mycobacteriosis using existing chemotherapeutics is more practical than awaiting the development of new antimycobacterial drugs. The regulation of host immune responses using immunoadjunctive agents may increase the efficacy of antimicrobial treatment against mycobacteriosis. In particular, the mild and long-term up-regulation of host immune reactions against mycobacterial pathogens using herbal medicines may be beneficial for such immunoadjunctive therapy. This review focuses on the current status regarding basic and clinical studies on protocols using herbal medicines, including medicinal plants, useful for the clinical treatment of intractable mycobacterial infections. View Full-Text
Keywords: herbal medicines; medicinal plants; immunoadjunctive agents; host-directed therapeutics; mycobacterial infections herbal medicines; medicinal plants; immunoadjunctive agents; host-directed therapeutics; mycobacterial infections
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Tomioka, H.; Tatano, Y.; Shimizu, T.; Sano, C. Clinical and Basic Studies on Therapeutic Efficacy of Herbal Medicines against Mycobacterial Infections. Medicines 2019, 6, 67.

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