Table of Contents
Toxics, Volume 6, Issue 4 (December 2018)
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Cover Story (view full-size image) Methylmercury (MeHg) is a ubiquitous environmental pollutant known to be neurotoxic, particularly [...] Read more. Methylmercury (MeHg) is a ubiquitous environmental pollutant known to be neurotoxic, particularly during fetal development. However, the mechanisms responsible for prenatal MeHg-induced changes in adult neuronal functions are not yet understood. Our experiments showed that cortical precursor exposed to a sub-nanomolar dose of MeHg led to increased neuronal differentiation, while its proliferation was inhibited. Reduced neuronal differentiation, however, was observed in the higher-dose groups. Our results suggest that sub-nanomolar MeHg exposure may deplete the pool of neural precursors by increasing premature neuronal differentiation, which can lead to long-term neurological effects in adulthood. View this paper.