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Inorganics 2018, 6(4), 126; https://doi.org/10.3390/inorganics6040126

Iron and Copper Intracellular Chelation as an Anticancer Drug Strategy

1
Department of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA
2
Department of Biology, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 28 September 2018 / Revised: 24 November 2018 / Accepted: 29 November 2018 / Published: 30 November 2018
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Abstract

A very promising direction in the development of anticancer drugs is inhibiting the molecular pathways that keep cancer cells alive and able to metastasize. Copper and iron are two essential metals that play significant roles in the rapid proliferation of cancer cells and several chelators have been studied to suppress the bioavailability of these metals in the cells. This review discusses the major contributions that Cu and Fe play in the progression and spreading of cancer and evaluates select Cu and Fe chelators that demonstrate great promise as anticancer drugs. Efforts to improve the cellular delivery, efficacy, and tumor responsiveness of these chelators are also presented including a transmetallation strategy for dual targeting of Cu and Fe. To elucidate the effectiveness and specificity of Cu and Fe chelators for treating cancer, analytical tools are described for measuring Cu and Fe levels and for tracking the metals in cells, tissue, and the body. View Full-Text
Keywords: copper and iron chelators in cancer; transmetalation; metastasis; angiogenesis; metallomics copper and iron chelators in cancer; transmetalation; metastasis; angiogenesis; metallomics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Gaur, K.; Vázquez-Salgado, A.M.; Duran-Camacho, G.; Dominguez-Martinez, I.; Benjamín-Rivera, J.A.; Fernández-Vega, L.; Carmona Sarabia, L.; Cruz García, A.; Pérez-Deliz, F.; Méndez Román, J.A.; Vega-Cartagena, M.; Loza-Rosas, S.A.; Rodriguez Acevedo, X.; Tinoco, A.D. Iron and Copper Intracellular Chelation as an Anticancer Drug Strategy. Inorganics 2018, 6, 126.

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