Next Article in Journal
Fluorolytic Sol–Gel Synthesis of Nanometal Fluorides: Accessing New Materials for Optical Applications
Next Article in Special Issue
Development and Validation of Liquid Chromatography-Based Methods to Assess the Lipophilicity of Cytotoxic Platinum(IV) Complexes
Previous Article in Journal / Special Issue
Iron and Copper Intracellular Chelation as an Anticancer Drug Strategy
Open AccessArticle

Synthesis, Reactivity Studies, and Cytotoxicity of Two trans-Iodidoplatinum(II) Complexes. Does Photoactivation Work?

1
Departamento de Química Inorgánica, Universidad Autónoma de Madrid, 28049-Madrid, Spain
2
IBIS, Campus Hospital Universitario Virgen del Rocío, 41013-Sevilla, Spain
3
Donostia International Physics Center, 20018-Donostia, Spain
*
Author to whom correspondence should be addressed.
Inorganics 2018, 6(4), 127; https://doi.org/10.3390/inorganics6040127
Received: 19 October 2018 / Revised: 21 November 2018 / Accepted: 23 November 2018 / Published: 3 December 2018
trans-Platinum complexes have been the landmark in unconventional drugs prompting the development of innovative structures that might exhibit chemical and biological profiles different to cisplatin. Iodido complexes signaled a new turning point in the platinum drug design field when their cytotoxicity was reevaluated and reported. In this new study, we have synthesized and evaluated diodidoplatinum complexes trans-[PtI2(amine)(pyridine)] bearing aliphatic amines (isopropylamine and methylamine) and pyridines in trans configuration. X-ray diffraction data support the structural characterization. Their cytotoxicity has been evaluated in tumor cell lines such as SAOS-2, A375, T-47D, and HCT116. Moreover, we report their solution behavior and reactivity with biological models. Ultraviolet-a (UVA) irradiation induces an increase in their reactivity towards model nucleobase 5′-GMP in early stages, and promotes the release of the pyridine ligand (spectator ligand) at longer reaction times. Density Functional calculations have been performed and the results are compared with our previous studies with other iodido derivatives. View Full-Text
Keywords: platinum iodido complexes; cytotoxicity; photoactivation platinum iodido complexes; cytotoxicity; photoactivation
Show Figures

Graphical abstract

MDPI and ACS Style

Cubo, L.; Parro, T.; Carnero, A.; Salassa, L.; Matesanz, A.I.; Quiroga, A.G. Synthesis, Reactivity Studies, and Cytotoxicity of Two trans-Iodidoplatinum(II) Complexes. Does Photoactivation Work? Inorganics 2018, 6, 127.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop