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Open AccessArticle

Synthesis, Reactivity Studies, and Cytotoxicity of Two trans-Iodidoplatinum(II) Complexes. Does Photoactivation Work?

Departamento de Química Inorgánica, Universidad Autónoma de Madrid, 28049-Madrid, Spain
IBIS, Campus Hospital Universitario Virgen del Rocío, 41013-Sevilla, Spain
Donostia International Physics Center, 20018-Donostia, Spain
Author to whom correspondence should be addressed.
Inorganics 2018, 6(4), 127;
Received: 19 October 2018 / Revised: 21 November 2018 / Accepted: 23 November 2018 / Published: 3 December 2018
trans-Platinum complexes have been the landmark in unconventional drugs prompting the development of innovative structures that might exhibit chemical and biological profiles different to cisplatin. Iodido complexes signaled a new turning point in the platinum drug design field when their cytotoxicity was reevaluated and reported. In this new study, we have synthesized and evaluated diodidoplatinum complexes trans-[PtI2(amine)(pyridine)] bearing aliphatic amines (isopropylamine and methylamine) and pyridines in trans configuration. X-ray diffraction data support the structural characterization. Their cytotoxicity has been evaluated in tumor cell lines such as SAOS-2, A375, T-47D, and HCT116. Moreover, we report their solution behavior and reactivity with biological models. Ultraviolet-a (UVA) irradiation induces an increase in their reactivity towards model nucleobase 5′-GMP in early stages, and promotes the release of the pyridine ligand (spectator ligand) at longer reaction times. Density Functional calculations have been performed and the results are compared with our previous studies with other iodido derivatives. View Full-Text
Keywords: platinum iodido complexes; cytotoxicity; photoactivation platinum iodido complexes; cytotoxicity; photoactivation
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MDPI and ACS Style

Cubo, L.; Parro, T.; Carnero, A.; Salassa, L.; Matesanz, A.I.; Quiroga, A.G. Synthesis, Reactivity Studies, and Cytotoxicity of Two trans-Iodidoplatinum(II) Complexes. Does Photoactivation Work? Inorganics 2018, 6, 127.

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