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Gadolinium(III)-DOTA Complex Functionalized with BODIPY as a Potential Bimodal Contrast Agent for MRI and Optical Imaging

Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Leuven 3001, Belgium
Author to whom correspondence should be addressed.
Academic Editors: Stephen Mansell and Steve Liddle
Inorganics 2015, 3(4), 516-533;
Received: 29 September 2015 / Revised: 10 November 2015 / Accepted: 17 November 2015 / Published: 25 November 2015
(This article belongs to the Special Issue Rare Earth and Actinide Complexes)
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The synthesis and characterization of a novel gadolinium(III) DOTA complex functionalized with a boron-dipyrromethene derivative (BODIPY) is described. The assembly of the complex relies on azide diazotransfer chemistry in a copper tube flow reactor. The azide thus formed is coupled directly with an alkyne via click chemistry, resulting into a paramagnetic and luminescent gadolinium(III) complex. Luminescent data and relaxometric properties of the complex have been evaluated, suggesting the potential applicability of the complexes as a bimodal contrast agent for magnetic resonance and optical imaging. The complex displays a bright emission at 523 nm with an absorption maximum of 507 nm and high quantum yields of up to 83% in water. The proton relaxivity of the complex measured at 310 K and at frequencies of 20 and 60 MHz had the values of 3.9 and 3.6 s1·mM1, respectively. View Full-Text
Keywords: Gadolinium(III); BODIPY; click chemistry; MRI; contrast agent Gadolinium(III); BODIPY; click chemistry; MRI; contrast agent

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Ceulemans, M.; Nuyts, K.; De Borggraeve, W.M.; Parac-Vogt, T.N. Gadolinium(III)-DOTA Complex Functionalized with BODIPY as a Potential Bimodal Contrast Agent for MRI and Optical Imaging. Inorganics 2015, 3, 516-533.

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