Novel Room Temperature Ionic Liquid for Liquid-Phase Microextraction of Cannabidiol from Natural Cosmetics

Huber, Susanne; Harder, Matthias; Funck, Kevin; Erharter, Kevin; Popp, Michael; Bonn, Günther K.; Rainer, Matthias

doi:10.3390/separations7030045

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Novel Room Temperature Ionic Liquid for Liquid-Phase Microextraction of Cannabidiol from Natural Cosmetics

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Institute of Analytical Chemistry and Radiochemistry, Leopold-Franzens University of Innsbruck, Innrain 80–82, Innsbruck 6020, Austria

Institute of Organic Chemistry, Leopold-Franzens University of Innsbruck, Innrain 80–82, Innsbruck 6020, Austria

Michael Popp Research Institute for New Phyto Entities, Leopold-Franzens University of Innsbruck, Mitterweg 24, Innsbruck 6020, Austria

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ADSI—Austrian Drug Screening Institute, Innrain 66a, Innsbruck 6020, Austria

Author to whom correspondence should be addressed.

Separations 2020, 7(3), 45; https://doi.org/10.3390/separations7030045

Received: 30 July 2020 / Revised: 20 August 2020 / Accepted: 24 August 2020 / Published: 26 August 2020

(This article belongs to the Special Issue Microextraction Techniques for Sample Preparation)

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Abstract

This study presents the synthesis of a novel asymmetric 1,3-di(alkoxy)imidazolium based room temperature ionic liquid, more precisely 1-butoxy-3-ethoxy-2-ethyl-imidazolium bis(trifluoromethane)sulfonimide, and its application as an extraction solvent in liquid-phase microextraction of cannabidiol from natural cosmetics. Quantification was implemented, using a high performance liquid chromatography system coupled to ultraviolet detection. Molecular structure elucidation was performed by nuclear magnetic resonance spectroscopy. The extraction procedure was optimized by means of two different design of experiments. Additionally, a full validation was executed. The established calibration model, ranging from 0.6 to 6.0 mg g⁻¹, was linear with a coefficient of determination of 0.9993. Accuracy and precision were demonstrated on four consecutive days with a bias within −2.6 to 2.3% and a maximum relative standard deviation value of 2.5%. Recoveries, tested for low and high concentration within the calibration range, were 80%. Stability of extracted cannabidiol was proven for three days at room temperature and fourteen days at 4 °C and −20 °C. An autosampler stability for 24 h was validated. Liquid-phase microextraction of cannabidiol from different formulated cream based cosmetics was performed, including four ointments and four creams. The results show that a significantly higher selectivity could be achieved compared to a conventional extraction methods with methanol. View Full-Text

Keywords: room temperature ionic liquid; cannabidiol; liquid-phase microextraction; cosmetic

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MDPI and ACS Style

Huber, S.; Harder, M.; Funck, K.; Erharter, K.; Popp, M.; Bonn, G.K.; Rainer, M. Novel Room Temperature Ionic Liquid for Liquid-Phase Microextraction of Cannabidiol from Natural Cosmetics. Separations 2020, 7, 45. https://doi.org/10.3390/separations7030045

AMA Style

Huber S, Harder M, Funck K, Erharter K, Popp M, Bonn GK, Rainer M. Novel Room Temperature Ionic Liquid for Liquid-Phase Microextraction of Cannabidiol from Natural Cosmetics. Separations. 2020; 7(3):45. https://doi.org/10.3390/separations7030045

Chicago/Turabian Style

Huber, Susanne, Matthias Harder, Kevin Funck, Kevin Erharter, Michael Popp, Günther K. Bonn, and Matthias Rainer. 2020. "Novel Room Temperature Ionic Liquid for Liquid-Phase Microextraction of Cannabidiol from Natural Cosmetics" Separations 7, no. 3: 45. https://doi.org/10.3390/separations7030045

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Novel Room Temperature Ionic Liquid for Liquid-Phase Microextraction of Cannabidiol from Natural Cosmetics

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