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Volume 6
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10.11599/germs.2016.1084
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GERMS is published by MDPI from Volume 25 Issue 4 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with the former publisher Infection Science Forum S.R.L..
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Article

IL-17 and IL-22 Genetic Polymorphisms in HBV Vaccine Non- and Low-Responders Among Healthcare Workers

by
Zohreh Borzooy
1,2,
Adrian Streinu-Cercel
3,4,*,
Abbass Mirshafiey
5,
Azam Khamseh
6,
Masoud Karkhaneh Mahmoudie
6,
Shadi Sadat Navabi
7,
Marjan Nosrati
8,
Zahra Najafi
9,
Mostafa Hosseini
10 and
Seyed Mohammad Jazayeri
11
1
Department of Infectious Diseases, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
2
Department of Immunology and Department of Virology, School of PublicHealth, Tehran Universityof Medical Sciences, Tehran, Iran
3
Department of Infectious Diseases, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
4
National Institute of Infectious Diseases, "Prof. Dr. Matei Balş”, Bucharest 021105, Romania
5
Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
6
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
7
Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran
8
Department of Infection Control, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
9
Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran
10
Department of Epidemiology and Biostatistics School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
11
Hepatitis B Molecular Laboratory, Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
 
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Author to whom correspondence should be addressed.
GERMS 2016, 6(1), 14-20; https://doi.org/10.11599/germs.2016.1084
Submission received: 15 October 2015 / Revised: 25 December 2015 / Accepted: 30 December 2015 / Published: 1 March 2016
Versions Notes

Abstract

Background: Healthcare workers constitute a population at high risk for HBV infection. Efficient vaccination options are available; however, the individual response to HBV vaccination may vary widely between subjects, potentially due to cytokine profiles and genetic variations. In the present study, we investigated the relationship between IL-17 and IL-22 gene polymorphisms versus non- and low-responsiveness to HBV vaccination in healthcare workers. Methods: We selected the following IL-17 and IL-22 polymorphisms: rs4711998 (A/G) from IL-17 and rs2227501 (A/T), rs2227503 (A/G), rs1026786 (A/G) from IL-22 sequences genes. These were determined by polymerase chain reaction restriction fragment length polymorphisms. Results: The IL-17 rs4711998 GG genotype had a significantly lower frequency in non-responders compared to low-responders (p = 0.025). However, we did not identify a relationship between IL-22 rs1026780, rs2227501 and rs2227503 genotypes and the anti-HBs response following HBV vaccination. Conclusion: These data suggest that genetic variation in rs4711998 polymorphisms in the IL-17 cytokine may influence vaccine-induced immune responses to HBV vaccine in healthcare workers.
Keywords: HBV vaccine; healthcare workers; IL-17; IL-22; gene polymorphisms HBV vaccine; healthcare workers; IL-17; IL-22; gene polymorphisms

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MDPI and ACS Style

Borzooy, Z.; Streinu-Cercel, A.; Mirshafiey, A.; Khamseh, A.; Mahmoudie, M.K.; Navabi, S.S.; Nosrati, M.; Najafi, Z.; Hosseini, M.; Jazayeri, S.M. IL-17 and IL-22 Genetic Polymorphisms in HBV Vaccine Non- and Low-Responders Among Healthcare Workers. GERMS 2016, 6, 14-20. https://doi.org/10.11599/germs.2016.1084

AMA Style

Borzooy Z, Streinu-Cercel A, Mirshafiey A, Khamseh A, Mahmoudie MK, Navabi SS, Nosrati M, Najafi Z, Hosseini M, Jazayeri SM. IL-17 and IL-22 Genetic Polymorphisms in HBV Vaccine Non- and Low-Responders Among Healthcare Workers. GERMS. 2016; 6(1):14-20. https://doi.org/10.11599/germs.2016.1084

Chicago/Turabian Style

Borzooy, Zohreh, Adrian Streinu-Cercel, Abbass Mirshafiey, Azam Khamseh, Masoud Karkhaneh Mahmoudie, Shadi Sadat Navabi, Marjan Nosrati, Zahra Najafi, Mostafa Hosseini, and Seyed Mohammad Jazayeri. 2016. "IL-17 and IL-22 Genetic Polymorphisms in HBV Vaccine Non- and Low-Responders Among Healthcare Workers" GERMS 6, no. 1: 14-20. https://doi.org/10.11599/germs.2016.1084

APA Style

Borzooy, Z., Streinu-Cercel, A., Mirshafiey, A., Khamseh, A., Mahmoudie, M. K., Navabi, S. S., Nosrati, M., Najafi, Z., Hosseini, M., & Jazayeri, S. M. (2016). IL-17 and IL-22 Genetic Polymorphisms in HBV Vaccine Non- and Low-Responders Among Healthcare Workers. GERMS, 6(1), 14-20. https://doi.org/10.11599/germs.2016.1084

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