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Influence of Carbon Quantum Dots on the Biome

Untangling the Potential of Carbon Quantum Dots in Neurodegenerative Disease

Tenafly High School, Tenafly, NJ 07670, USA
Department of Preclinical Research, Angion Biomedica Corp., Uniondale, NY 11553, USA
Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, TX 79968, USA
Authors to whom correspondence should be addressed.
Processes 2020, 8(5), 599;
Received: 18 March 2020 / Revised: 12 May 2020 / Accepted: 13 May 2020 / Published: 18 May 2020
(This article belongs to the Special Issue Protein Biosynthesis and Drug Design & Delivery Processes)
The transitioning of carbon quantum dot (cQD) applications from electrochemistry, catalysis and environmental sensing to biomedicine represents an important milestone in its 15-year history; a bellwether for its yet-unrealized potential in interventional biology, imaging, diagnostics, prophylaxis and therapy. However, despite the significant advances made over the last decade in several areas of the cQD domain, our knowledge of the exact chemical ipseity of cQDs at the Angstrom level remains either in its infancy or is largely ignored. The imminent crossing over of cQDs into biological systems and into the blood–brain barrier demands attention to the critical, yet unmet, need to resolve the inherent heterogeneity in cQD preparations and their separation into purified conformers, to identify the issues associated with potential cytotoxicity as well as to examine their bioavailability. Perhaps most importantly, and ironically neglected as well, is the compelling urgency to obtain an atomic- and molecular-level understanding of cQD’s interactions with biological receptors; a demand that requires absolute knowledge of its structure, chemistry and aspects therein. The need for the total chemical mapping of cQDs, with Angstrom-level resolution, remains the unrealized cornerstone to tailoring its specificity for its designated use in preclinical and clinical trials. View Full-Text
Keywords: carbon quantum dots; heterogeneity; structure carbon quantum dots; heterogeneity; structure
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MDPI and ACS Style

Jung, L.; Narayan, P.; Sreenivasan, S.T.; Narayan, M. Untangling the Potential of Carbon Quantum Dots in Neurodegenerative Disease. Processes 2020, 8, 599.

AMA Style

Jung L, Narayan P, Sreenivasan ST, Narayan M. Untangling the Potential of Carbon Quantum Dots in Neurodegenerative Disease. Processes. 2020; 8(5):599.

Chicago/Turabian Style

Jung, Lindsey, Prakash Narayan, Sreeprasad T. Sreenivasan, and Mahesh Narayan. 2020. "Untangling the Potential of Carbon Quantum Dots in Neurodegenerative Disease" Processes 8, no. 5: 599.

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