Next Article in Journal
Valuation of the Energy Performance of a Greenhouse with an Electric Heater Using Numerical Simulations
Previous Article in Journal
Activated Sludge Respiration Activity Inhibition Caused by Mobile Toilet Chemicals
Previous Article in Special Issue
Influence of Carbon Quantum Dots on the Biome
Open AccessFeature PaperCommentary

Untangling the Potential of Carbon Quantum Dots in Neurodegenerative Disease

1
Tenafly High School, Tenafly, NJ 07670, USA
2
Department of Preclinical Research, Angion Biomedica Corp., Uniondale, NY 11553, USA
3
Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, TX 79968, USA
*
Authors to whom correspondence should be addressed.
Processes 2020, 8(5), 599; https://doi.org/10.3390/pr8050599
Received: 18 March 2020 / Revised: 12 May 2020 / Accepted: 13 May 2020 / Published: 18 May 2020
(This article belongs to the Special Issue Protein Biosynthesis and Drug Design & Delivery Processes)
The transitioning of carbon quantum dot (cQD) applications from electrochemistry, catalysis and environmental sensing to biomedicine represents an important milestone in its 15-year history; a bellwether for its yet-unrealized potential in interventional biology, imaging, diagnostics, prophylaxis and therapy. However, despite the significant advances made over the last decade in several areas of the cQD domain, our knowledge of the exact chemical ipseity of cQDs at the Angstrom level remains either in its infancy or is largely ignored. The imminent crossing over of cQDs into biological systems and into the blood–brain barrier demands attention to the critical, yet unmet, need to resolve the inherent heterogeneity in cQD preparations and their separation into purified conformers, to identify the issues associated with potential cytotoxicity as well as to examine their bioavailability. Perhaps most importantly, and ironically neglected as well, is the compelling urgency to obtain an atomic- and molecular-level understanding of cQD’s interactions with biological receptors; a demand that requires absolute knowledge of its structure, chemistry and aspects therein. The need for the total chemical mapping of cQDs, with Angstrom-level resolution, remains the unrealized cornerstone to tailoring its specificity for its designated use in preclinical and clinical trials. View Full-Text
Keywords: carbon quantum dots; heterogeneity; structure carbon quantum dots; heterogeneity; structure
Show Figures

Figure 1

MDPI and ACS Style

Jung, L.; Narayan, P.; Sreenivasan, S.T.; Narayan, M. Untangling the Potential of Carbon Quantum Dots in Neurodegenerative Disease. Processes 2020, 8, 599.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop