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Open AccessArticle

Herbal Tea for the Management of Pharyngitis: Inhibition of Streptococcus pyogenes Growth and Biofilm Formation by Herbal Infusions

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Department of Biology, Faculty of Science, Dalhousie University, Halifax, NS 3H 4R2, Canada
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Department of Animal Science, Faculty of Animal Science and Export Agriculture, Uva Wellassa University, Badulla 90 000, Sri Lanka
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Department of Plant, Food, and Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, NS B2N 5E3, Canada
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Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada
*
Author to whom correspondence should be addressed.
Biomedicines 2019, 7(3), 63; https://doi.org/10.3390/biomedicines7030063
Received: 4 August 2019 / Revised: 21 August 2019 / Accepted: 23 August 2019 / Published: 24 August 2019
(This article belongs to the Section Natural Compounds in Biomedicine)
Herbal teas are becoming popular as functional beverages due to their various health promotional properties. This study aimed at assessing 13 hot water infusions (HWIs) from different herbs against streptococcal pharyngitis (strep throat). Licorice root exhibited the lowest minimum inhibitory concentrations (MIC) of 1.56 mg/mL, followed by barberry root, thyme, and oregano flowering shoots, with a MIC of 3.13 mg/mL. At their respective minimum bactericidal concentrations (MBC), licorice showed the bactericidal effect on S. pyogenes within 12 h after exposure while others need 24 h for a similar outcome. The HWIs exhibited inhibitory activity on biofilm formation, ranging from 1.56 to 6.25 mg/mL, which confirmed by ruptured cells or clusters of dead cell debris observed in scanning electron microscope (SEM). Overall, non-toxic concentrations of efficacious HWIs from licorice root, barberry root, thyme, and oregano flowering shoots may provide potential sources for developing herbal teas or biomedicine for the management of S. pyogenes infections. View Full-Text
Keywords: herbal plants; hot water infusions; phytochemicals; natural health product; Streptococcus pyogenes; mass spectrometry herbal plants; hot water infusions; phytochemicals; natural health product; Streptococcus pyogenes; mass spectrometry
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MDPI and ACS Style

Wijesundara, N.M.; Rupasinghe, H.P.V. Herbal Tea for the Management of Pharyngitis: Inhibition of Streptococcus pyogenes Growth and Biofilm Formation by Herbal Infusions. Biomedicines 2019, 7, 63.

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