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Biomedicines 2018, 6(1), 6;

Non Melanoma Skin Cancer Pathogenesis Overview

Klinik für Dermatologie und Allergologie, Universitätsklinikum Marburg, Baldingerstraße, 35043 Marburg, Germany
Department of Dermatology, Sapienza Università di Roma, Rome 00100, Italy
Department of Dermatology, Università della Magna Grecia, Catanzaro 88100, Italy
Author to whom correspondence should be addressed.
Received: 16 November 2017 / Revised: 7 December 2017 / Accepted: 20 December 2017 / Published: 2 January 2018
(This article belongs to the Special Issue Photodynamic Therapy in Cancer)
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(1) Background: Non-melanoma skin cancer is the most frequently diagnosed cancer in humans. The process of skin carcinogenesis is still not fully understood. However, several studies have been conducted to better explain the mechanisms that lead to malignancy; (2) Methods: We reviewed the more recent literature about the pathogenesis of non-melanoma skin cancer focusing on basal cell carcinomas, squamous cell carcinoma and actinic keratosis; (3) Results: Several papers reported genetic and molecular alterations leading to non-melanoma skin cancer. Plenty of risk factors are involved in non-melanoma skin cancer pathogenesis, including genetic and molecular alterations, immunosuppression, and ultraviolet radiation; (4) Conclusion: Although skin carcinogenesis is still not fully understood, several papers demonstrated that genetic and molecular alterations are involved in this process. In addition, plenty of non-melanoma skin cancer risk factors are now known, allowing for an effective prevention of non-melanoma skin cancer development. Compared to other papers on the same topic, our review focused on molecular and genetic factors and analyzed in detail several factors involved in non-melanoma skin cancer. View Full-Text
Keywords: actinic keratosis; pathogenesis; precancerous conditions; skin neoplasms actinic keratosis; pathogenesis; precancerous conditions; skin neoplasms

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Didona, D.; Paolino, G.; Bottoni, U.; Cantisani, C. Non Melanoma Skin Cancer Pathogenesis Overview. Biomedicines 2018, 6, 6.

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