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Biomedicines 2018, 6(1), 5; https://doi.org/10.3390/biomedicines6010005

Programming of Cell Resistance to Genotoxic and Oxidative Stress

1
Institute of Biology of Komi Science Centre of Ural Branch of RAS, Syktyvkar 167982, Russia
2
Polytechnical Institute of Vyatka State University, Kirov 610000, Russia
3
Biology department of St. Olaf College, Northfield, MN 55057, USA
*
Author to whom correspondence should be addressed.
Received: 29 October 2017 / Revised: 23 December 2017 / Accepted: 31 December 2017 / Published: 2 January 2018
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Abstract

Different organisms, cell types, and even similar cell lines can dramatically differ in resistance to genotoxic stress. This testifies to the wide opportunities for genetic and epigenetic regulation of stress resistance. These opportunities could be used to increase the effectiveness of cancer therapy, develop new varieties of plants and animals, and search for new pharmacological targets to enhance human radioresistance, which can be used for manned deep space expeditions. Based on the comparison of transcriptomic studies in cancer cells, in this review, we propose that there is a high diversity of genetic mechanisms of development of genotoxic stress resistance. This review focused on possibilities and limitations of the regulation of the resistance of normal cells and whole organisms to genotoxic and oxidative stress by the overexpressing of stress-response genes. Moreover, the existing experimental data on the effect of such overexpression on the resistance of cells and organisms to various genotoxic agents has been analyzed and systematized. We suggest that the recent advances in the development of multiplex and highly customizable gene overexpression technology that utilizes the mutant Cas9 protein and the abundance of available data on gene functions and their signal networks open new opportunities for research in this field. View Full-Text
Keywords: cell programming; stress resistance; gene overexpression; radiation; oxidative stress; chemical genotoxins; malignant transformation; diversity of mechanisms cell programming; stress resistance; gene overexpression; radiation; oxidative stress; chemical genotoxins; malignant transformation; diversity of mechanisms
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Velegzhaninov, I.O.; Ievlev, V.A.; Pylina, Y.I.; Shadrin, D.M.; Vakhrusheva, O.M. Programming of Cell Resistance to Genotoxic and Oxidative Stress. Biomedicines 2018, 6, 5.

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