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Open AccessArticle

Electrosprayed Nanoparticles Based on Hyaluronic Acid: Preparation and Characterization

Institute BioEngineering, ITMO University, Kronverkskiy prospekt, 49A, 197101 St. Petersburg, Russia
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Technologies 2020, 8(4), 71; https://doi.org/10.3390/technologies8040071
Received: 17 October 2020 / Revised: 13 November 2020 / Accepted: 24 November 2020 / Published: 27 November 2020
Modern drug delivery systems demand the development of targeted polymer-carriers with the set of obligatory requirements. Thus, such capsules must have total biocompatibility, biodegradability, and possess non-allergenic, and non-tumorigenic properties. Hyaluronic acid (HA), as a natural linear polysaccharide that is included in the pericellular and extracellular matrixes, satisfies all these demands in the best possible way. In this study, the biopolymer nanoparticles with an average diameter of 300 nm were successfully obtained from aqueous HA solutions by electrospraying technique and characterized. Due to the presence of active functional groups in the structure of HA, such polymer particles can incorporate various pharmaceutical agents. This finding expands the investigation and subsequent application of drug-loaded nanoparticles based on HA as challenging and advanced targeted delivery systems. View Full-Text
Keywords: biopolymer; drug delivery; electrical conductivity; electrospinning; electrospraying; hyaluronic acid; nanoparticles; spraying solutions; surface tension; viscosity biopolymer; drug delivery; electrical conductivity; electrospinning; electrospraying; hyaluronic acid; nanoparticles; spraying solutions; surface tension; viscosity
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MDPI and ACS Style

Snetkov, P.; Zakharova, K.; Morozkina, S.; Baranov, M.; Olekhnovich, R.; Uspenskaya, M. Electrosprayed Nanoparticles Based on Hyaluronic Acid: Preparation and Characterization. Technologies 2020, 8, 71. https://doi.org/10.3390/technologies8040071

AMA Style

Snetkov P, Zakharova K, Morozkina S, Baranov M, Olekhnovich R, Uspenskaya M. Electrosprayed Nanoparticles Based on Hyaluronic Acid: Preparation and Characterization. Technologies. 2020; 8(4):71. https://doi.org/10.3390/technologies8040071

Chicago/Turabian Style

Snetkov, Petr; Zakharova, Kseniia; Morozkina, Svetlana; Baranov, Mikhail; Olekhnovich, Roman; Uspenskaya, Mayya. 2020. "Electrosprayed Nanoparticles Based on Hyaluronic Acid: Preparation and Characterization" Technologies 8, no. 4: 71. https://doi.org/10.3390/technologies8040071

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