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Retinoids in Stellate Cells: Development, Repair, and Regeneration

1
Department of Animal Biology, Faculty of Science, University of Málaga, 29071 Málaga, Spain
2
Andalusian Center for Nanomedicine and Biotechnology (BIONAND), 29590 Málaga, Spain
*
Author to whom correspondence should be addressed.
J. Dev. Biol. 2019, 7(2), 10; https://doi.org/10.3390/jdb7020010
Received: 18 April 2019 / Revised: 15 May 2019 / Accepted: 17 May 2019 / Published: 24 May 2019
(This article belongs to the Special Issue Retinoids in Development 2019)
Stellate cells, either hepatic (HSCs) or pancreatic (PSCs), are a type of interstitial cells characterized by their ability to store retinoids in lipid vesicles. In pathological conditions both HSCs and PSCs lose their retinoid content and transform into fibroblast-like cells, contributing to the fibrogenic response. HSCs also participate in other functions including vasoregulation, drug detoxification, immunotolerance, and maintenance of the hepatocyte population. PSCs maintain pancreatic tissue architecture and regulate pancreatic exocrine function. Recently, PSCs have attracted the attention of researchers due to their interactions with pancreatic ductal adenocarcinoma cells. PSCs promote tumour growth and angiogenesis, and their fibrotic activity increases the resistance of pancreatic cancer to chemotherapy and radiation. We are reviewing the current literature concerning the role played by retinoids in the physiology and pathophysiology of the stellate cells, paying attention to their developmental aspects as well as the function of stellate cells in tissue repair and organ regeneration. View Full-Text
Keywords: hepatic stellate cells; pancreatic stellate cells; Ito cells; retinoids; retinoic acid; tissue repair; organ regeneration; pancreatic ductal adenocarcinoma hepatic stellate cells; pancreatic stellate cells; Ito cells; retinoids; retinoic acid; tissue repair; organ regeneration; pancreatic ductal adenocarcinoma
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MDPI and ACS Style

Carmona, R.; Barrena, S.; Muñoz-Chápuli, R. Retinoids in Stellate Cells: Development, Repair, and Regeneration. J. Dev. Biol. 2019, 7, 10. https://doi.org/10.3390/jdb7020010

AMA Style

Carmona R, Barrena S, Muñoz-Chápuli R. Retinoids in Stellate Cells: Development, Repair, and Regeneration. Journal of Developmental Biology. 2019; 7(2):10. https://doi.org/10.3390/jdb7020010

Chicago/Turabian Style

Carmona, Rita; Barrena, Silvia; Muñoz-Chápuli, Ramón. 2019. "Retinoids in Stellate Cells: Development, Repair, and Regeneration" J. Dev. Biol. 7, no. 2: 10. https://doi.org/10.3390/jdb7020010

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