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J. Dev. Biol., Volume 3, Issue 1 (March 2015) , Pages 1-24

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Open AccessReview
Inhibition of SERPINE1 Function Attenuates Wound Closure in Response to Tissue Injury: A Role for PAI-1 in Re-Epithelialization and Granulation Tissue Formation
J. Dev. Biol. 2015, 3(1), 11-24; https://doi.org/10.3390/jdb3010011 - 02 Mar 2015
Cited by 5 | Viewed by 4762
Abstract
Plasminogen activator inhibitor-1 (PAI-1; SERPINE1) is a prominent member of the serine protease inhibitor superfamily (SERPIN) and a causative factor of multi-organ fibrosis as well as a key regulator of the tissue repair program. PAI-1 attenuates pericellular proteolysis by inhibiting the catalytic activity [...] Read more.
Plasminogen activator inhibitor-1 (PAI-1; SERPINE1) is a prominent member of the serine protease inhibitor superfamily (SERPIN) and a causative factor of multi-organ fibrosis as well as a key regulator of the tissue repair program. PAI-1 attenuates pericellular proteolysis by inhibiting the catalytic activity of both urokinase and tissue-type protease activators (uPA and tPA) effectively modulating, thereby, plasmin-mediated fibrinolysis and the overall pericellular proteolytic cascade. PAI-1 also impacts cellular responses to tissue injury and stress situations (growth, survival, migration) by titering the locale and temporal activation of multimeric cell-surface signaling complexes. This review will describe PAI-1 structure and function and detail the role of PAI-1 in the tissue repair program with an emphasis on cutaneous wound healing. Full article
(This article belongs to the Special Issue Wound Healing and Tissue Regeneration)
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Open AccessCommunication
Strain-Dependent Gene Expression during Mouse Embryonic Palate Development
J. Dev. Biol. 2015, 3(1), 2-10; https://doi.org/10.3390/jdb3010002 - 06 Feb 2015
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Abstract
The effect of strain background on gene function in growth and development has been well documented. However, it has not been extensively reported whether the strain background affects the gene expression pattern. Here, we found that the expression of homeobox gene Meox-2 and [...] Read more.
The effect of strain background on gene function in growth and development has been well documented. However, it has not been extensively reported whether the strain background affects the gene expression pattern. Here, we found that the expression of homeobox gene Meox-2 and FGF receptor 1 gene Fgfr1 during mouse palate development is strain-dependent. On the C57B6 inbred background, Meox-2 is expressed in the palatal outgrowth on Embryonic Day 11.5 (E11.5); the expression shifts posteriorly and is restricted to the back of palate on E14.5. On the Swiss Webster outbred background, Meox-2 expression covers both anterior and posterior regions with the same intensity from E12.5 to E14.5. On the Black Swiss background, Meox-2 expression also covers the entire palate A-P axis, but is much weaker in the anterior region on E14.5. Fgfr1 also displays distinct expression patterns in the palatal outgrowth on E11.5 in these three strains. On the Black Swiss outbred background, the expression is restricted to the anterior palatal outgrowth. In marked contrast, the expression in the Swiss Webster outbred strain is located exclusively in the posterior palate outgrowth on E11.5, whereas in the C57B6 inbred strain, the expression is undetectable in the palatal outgrowth on E11.5. Full article
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Open AccessEditorial
Acknowledgement to Reviewers of the Journal of Developmental Biology in 2014
J. Dev. Biol. 2015, 3(1), 1; https://doi.org/10.3390/jdb3010001 - 09 Jan 2015
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Abstract
The editors of the Journal of Developmental Biology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2014:[...] Full article
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