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N-Acyl Amino Acids: Metabolism, Molecular Targets, and Role in Biological Processes

1
Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy
2
Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
3
Endocannabinoid Research Group, Institute of Translational Pharmacology, National Research Council, 00133 Rome, Italy
*
Authors to whom correspondence should be addressed.
Biomolecules 2019, 9(12), 822; https://doi.org/10.3390/biom9120822
Received: 15 October 2019 / Revised: 18 November 2019 / Accepted: 29 November 2019 / Published: 3 December 2019
(This article belongs to the Special Issue Bioactive Lipids in Health and Disease)
The lipid signal is becoming increasingly crowded as increasingly fatty acid amide derivatives are being identified and considered relevant therapeutic targets. The identification of N-arachidonoyl-ethanolamine as endogenous ligand of cannabinoid type-1 and type-2 receptors as well as the development of different –omics technologies have the merit to have led to the discovery of a huge number of naturally occurring N-acyl-amines. Among those mediators, N-acyl amino acids, chemically related to the endocannabinoids and belonging to the complex lipid signaling system now known as endocannabinoidome, have been rapidly growing for their therapeutic potential. Here, we review the current knowledge of the mechanisms for the biosynthesis and inactivation of the N-acyl amino acids, as well as the various molecular targets for some of the N-acyl amino acids described so far.
Keywords: N-acyl amino acids; N-acyl Glycines; N-acyl Serines N-acyl amino acids; N-acyl Glycines; N-acyl Serines
MDPI and ACS Style

Battista, N.; Bari, M.; Bisogno, T. N-Acyl Amino Acids: Metabolism, Molecular Targets, and Role in Biological Processes. Biomolecules 2019, 9, 822.

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