Next Article in Journal
Beyond the Usual Suspects: Physiological Roles of the Arabidopsis Amidase Signature (AS) Superfamily Members in Plant Growth Processes and Stress Responses
Previous Article in Journal
Toll-like Receptor 2 as a Marker Molecule of Advanced Ovarian Cancer
 
 
Article

Sex-Biased Expression of Pharmacogenes across Human Tissues

1
Institute of Genetics and Biomedical research, 07100 Sassari, Italy
2
Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
3
Unit of Environmental Epidemiology, School of Public Health, Imperial College, London SW7 2AZ, UK
4
Hospital Pharmacy Unit, Trento General Hospital, Autonomous Province of Trento, 38122 Trento, Italy
5
Department of Chemistry and Pharmacy, School of Hospital Pharmacy, University of Sassari, 07100 Sassari, Italy
6
National Laboratory of Pharmacology and Gender medicine, National Institute of Biostructure and Biosystems, 00136 Rome, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Giuseppe Palumbo
Biomolecules 2021, 11(8), 1206; https://doi.org/10.3390/biom11081206
Received: 25 June 2021 / Revised: 5 August 2021 / Accepted: 11 August 2021 / Published: 13 August 2021
Individual response to drugs is highly variable and largely influenced by genetic variants and gene-expression profiles. In addition, it has been shown that response to drugs is strongly sex-dependent, both in terms of efficacy and toxicity. To expand current knowledge on sex differences in the expression of genes relevant for drug response, we generated a catalogue of differentially expressed human transcripts encoded by 289 genes in 41 human tissues from 838 adult individuals of the Genotype-Tissue Expression project (GTEx, v8 release) and focused our analysis on relevant transcripts implicated in drug response. We detected significant sex-differentiated expression of 99 transcripts encoded by 59 genes in the tissues most relevant for human pharmacology (liver, lung, kidney, small intestine terminal ileum, skin not sun-exposed, and whole blood). Among them, as expected, we confirmed significant differences in the expression of transcripts encoded by the cytochromes in the liver, CYP2B6, CYP3A7, CYP3A5, and CYP1A1. Our systematic investigation on differences between male and female in the expression of drug response-related genes, reinforce the need to overcome the sex bias of clinical trials. View Full-Text
Keywords: pharmacogenes; transcripts; sex-bias; drug metabolism; sex differences pharmacogenes; transcripts; sex-bias; drug metabolism; sex differences
Show Figures

Figure 1

MDPI and ACS Style

Idda, M.L.; Campesi, I.; Fiorito, G.; Vecchietti, A.; Urru, S.A.M.; Solinas, M.G.; Franconi, F.; Floris, M. Sex-Biased Expression of Pharmacogenes across Human Tissues. Biomolecules 2021, 11, 1206. https://doi.org/10.3390/biom11081206

AMA Style

Idda ML, Campesi I, Fiorito G, Vecchietti A, Urru SAM, Solinas MG, Franconi F, Floris M. Sex-Biased Expression of Pharmacogenes across Human Tissues. Biomolecules. 2021; 11(8):1206. https://doi.org/10.3390/biom11081206

Chicago/Turabian Style

Idda, Maria Laura, Ilaria Campesi, Giovanni Fiorito, Andrea Vecchietti, Silvana Anna Maria Urru, Maria Giuliana Solinas, Flavia Franconi, and Matteo Floris. 2021. "Sex-Biased Expression of Pharmacogenes across Human Tissues" Biomolecules 11, no. 8: 1206. https://doi.org/10.3390/biom11081206

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop