Relevance of Gene Expression of Pharmacogenes for Drug Response and Toxicity

Dear Colleagues,

The identification of new cellular and molecular pathways is fundamental to deeply understand the molecular mechanisms underlying individual differences in drug response and toxicity.

The achievement of high-throughput technologies, and large-scale RNA expression projects, such as ENCODE and Genotype-Tissue Expression (GTEx), is driving remarkable change in the field.

Indeed, the large amount of genomic data available today represents a key component for the identification of clinically relevant differences implicated in drug response and, thus, in achieving personalized therapies.

The rising interest in personalized medicine in clinical practice is, in fact, essential to understanding the impact of individual variability on the incidence and manifestation of diseases and, therefore, to adapting therapies in a targeted manner to reduce the occurrence of adverse drug reactions.

Such a need is further reinforced by the fact that more than 95% of patients carry at least 1 actionable pharmacogene.

The aim of this Special Issue is to increase our knowledge and comprehension regarding the modulation of gene expression of pharmacogenes, particularly with regard to (i) the functional consequences of pharmacogenetic relevant variants and (ii) the practical implications in terms of precision medicine and reduction of adverse drug reactions.

Experts and beginners are welcome to contribute to this Special Issue focused on:

• Mechanisms of gene expression involving key genes implicated in drug response and toxicity;
• Splicing defects in pharmacogenes;
• Non-coding RNAs implicated in drug metabolism, response, and toxicity;
• Identification of inter-individual and inter-population differences in gene expression of pharmacogenes.

Meta-analyses of current knowledge around this topic are encouraged.

Dr. Ilaria Campesi
Prof. Dr. Matteo Floris
Dr. Maria Laura Idda
Dr. Magdalena Zoledziewska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• gene expression
• pharmacogenetics
• pharmacogene
• ncRNAs
• personalized medicine
• drug response