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Article

Determination of the Qualitative Composition of Biologically-Active Substances of Extracts of In Vitro Callus, Cell Suspension, and Root Cultures of the Medicinal Plant Rhodiola rosea

1
Department of Bionanotechnology, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia
2
Institute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, Russia
3
Natural Nutraceutical Biotesting Laboratory, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia
4
Department of General Mathematics and Informatics, Kemerovo State University, Krasnaya Street, 6, 650043 Kemerovo, Russia
5
Laboratory of Biocatalysis, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia
6
Kuzbass State Agricultural Academy, Markovtseva Street, 5, 650056 Kemerovo, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Joanna Kolniak-Ostek
Biomolecules 2021, 11(3), 365; https://doi.org/10.3390/biom11030365
Received: 20 January 2021 / Revised: 18 February 2021 / Accepted: 23 February 2021 / Published: 27 February 2021
The results of the qualitative composition analysis of the dried biomass extracts of in vitro callus, cell suspension, and root cultures show that the main biologically active substances (BAS) in the medicinal plant, Rhodiola rosea, are 6-C-(1-(4-hydroxyphenyl)ethyl)aromadendrin (25 mg, yield 0.21%), 2-(3,7-dihydroxy-2-(2-hydroxypropan-2-yl)-2,3-dihydrobenzofuran-5-yl)-6,7-dihydroxychroman-4-one (23 mg, yield 0.2%), 2-(3,4-dimethoxyphenyl)-5,7-dimethoxychroman-4-one (175 mg, yield 1.5%), 5,7-dihydroxy-2-(4-hydroxy-3-(2-(4-hydroxyphenyl)-4-oxo-4H-chromen-6-yl)phenyl)-4H-chromen-4-one (45 mg, yield 0.5%), 5,6,7,8-tetrahydroxy-4-methoxyflavone (0.35 mg, 0.5%). BAS from the dried biomass extracts of in vitro callus, cell suspension, and root cultures of Rhodiola rosea will be used for the production of pharmaceuticals and dietary supplements with antitumor, antimicrobial, and antioxidant effects. View Full-Text
Keywords: in vitro callus; cell suspension; root cultures; Rhodiola rosea; biologically-active substances; HPLC; 1H NMR spectra in vitro callus; cell suspension; root cultures; Rhodiola rosea; biologically-active substances; HPLC; 1H NMR spectra
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MDPI and ACS Style

Asyakina, L.; Sukhikh, S.; Ivanova, S.; Prosekov, A.; Ulrikh, E.; Chupahin, E.; Babich, O. Determination of the Qualitative Composition of Biologically-Active Substances of Extracts of In Vitro Callus, Cell Suspension, and Root Cultures of the Medicinal Plant Rhodiola rosea. Biomolecules 2021, 11, 365. https://doi.org/10.3390/biom11030365

AMA Style

Asyakina L, Sukhikh S, Ivanova S, Prosekov A, Ulrikh E, Chupahin E, Babich O. Determination of the Qualitative Composition of Biologically-Active Substances of Extracts of In Vitro Callus, Cell Suspension, and Root Cultures of the Medicinal Plant Rhodiola rosea. Biomolecules. 2021; 11(3):365. https://doi.org/10.3390/biom11030365

Chicago/Turabian Style

Asyakina, Lyudmila, Stanislav Sukhikh, Svetlana Ivanova, Alexander Prosekov, Elena Ulrikh, Evgeny Chupahin, and Olga Babich. 2021. "Determination of the Qualitative Composition of Biologically-Active Substances of Extracts of In Vitro Callus, Cell Suspension, and Root Cultures of the Medicinal Plant Rhodiola rosea" Biomolecules 11, no. 3: 365. https://doi.org/10.3390/biom11030365

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