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Open AccessArticle

Association of Circulating COMP and YKL-40 as Markers of Metabolic Changes of Cartilage with Adipocytokines in Juvenile Idiopathic Arthritis

1
Department of Clinical Chemistry and Laboratory Diagnostics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, ul. Jedności 8, 41-200 Sosnowiec, Poland
2
Department of Rheumatology, The John Paul II Pediatric Center in Sosnowiec, ul. Gabrieli Zapolskiej 3, 41-218 Sosnowiec, Poland
*
Author to whom correspondence should be addressed.
Metabolites 2020, 10(2), 61; https://doi.org/10.3390/metabo10020061
Received: 16 January 2020 / Revised: 1 February 2020 / Accepted: 6 February 2020 / Published: 10 February 2020
(This article belongs to the Special Issue Metabolomics Analysis for Biomarker Discovery and Human Health)
The aim of this study was to evaluate the association of circulating cartilage oligomeric matrix protein (COMP) and human cartilage glycoprotein-39 (YKL-40) as markers of metabolic changes of cartilage, with leptin, adiponectin, and resistin in juvenile idiopathic arthritis (JIA) patients before and after treatment. A significant decrease of COMP and an increase of YKL-4 were found in blood of untreated patients. JIA treatment leading to clinical improvement resulted in normalization of COMP levels only. Concentrations of both markers in treated patients, while showing no clinical improvement, differed from those in controls and patients with remission. The leptin level decreased (p < 0.05) in untreated patients; however, concentrations of adiponectin and resistin increased (p < 0.05) as compared to controls. JIA treatment resulted in normalization of adipocytokine levels in remissive patients but not those with active JIA. Untreated patients showed a correlation between COMP and leptin, adiponectin, and body mass index (BMI) and between YKL-40 and leptin, adiponectin, BMI, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). In inactive JIA, a correlation between YKL-40 and leptin was shown. Treated patients with an active JIA demonstrated a correlation between COMP and adiponectin and between YKL-40 and leptin, adiponectin, BMI, CRP, and ESR. The results of this work indicate that leptin and adiponectin but not resistin may be involved in the development and progression of joint dysfunction in JIA. Additionally, we suggest that YKL-40 may be a useful biomarker of disease activity and may be used to assess treatment towards remission, as compared to COMP.
Keywords: juvenile idiopathic arthritis; cartilage degradation markers; cartilage oligomeric matrix protein; human cartilage glycoprotein 39; adipocytokines; leptin; adiponectin; resistin juvenile idiopathic arthritis; cartilage degradation markers; cartilage oligomeric matrix protein; human cartilage glycoprotein 39; adipocytokines; leptin; adiponectin; resistin
MDPI and ACS Style

Winsz-Szczotka, K.; Kuźnik-Trocha, K.; Gruenpeter, A.; Wojdas, M.; Dąbkowska, K.; Olczyk, K. Association of Circulating COMP and YKL-40 as Markers of Metabolic Changes of Cartilage with Adipocytokines in Juvenile Idiopathic Arthritis. Metabolites 2020, 10, 61.

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