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Scientia Pharmaceutica, Volume 85, Issue 4

December 2017 - 4 articles

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Articles (4)

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Article

3 Citations

3,674 Views

9 Pages

Theoretical Investigation of the Enantioselective Complexations between pfDHFR and Cycloguanil Derivatives

Suriyawut Kulatee,
Pisanu Toochinda,
Anotai Suksangpanomrung and
Luckhana Lawtrakul

Sci. Pharm.2017, 85(4), 37;https://doi.org/10.3390/scipharm85040037

21 November 2017

Point mutations in Plasmodium falciparum dihydrofolate reductase (pfDHFR), especially the double mutant variant (A16V + S108T), led to ineffective inhibiting by cycloguanil (Cyc). Cycloguanil derivatives showed good inhibiting properties against wild...

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Article

72 Citations

7,263 Views

9 Pages

Leishmanicidal Activity of Biogenic Fe₃O₄ Nanoparticles

Mehrdad Khatami,
Hajar Alijani,
Iraj Sharifi,
Fatemeh Sharifi,
Shahram Pourseyedi,
Sam Kharazi,
Marcos Augusto Lima Nobre and
Manouchehr Khatami

Sci. Pharm.2017, 85(4), 36;https://doi.org/10.3390/scipharm85040036

20 November 2017

Abstract: Due to the multiplicity of useful applications of metal oxide nanoparticles (ONPs) in medicine are growing exponentially, in this study, Fe3O4 (iron oxide) nanoparticles (IONPs) were biosynthesized using Rosemary to evaluate the leishmanici...

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Article

13 Citations

4,506 Views

12 Pages

Hydrogen Sulfide Releasing 2-Mercaptoacrylic Acid-Based Derivative Possesses Cytoprotective Activity in a Small Intestine of Rats with Medication-Induced Enteropathy

Yulia Sklyarova,
Iryna Fomenko,
Iryna Lozynska,
Andrii Lozynskyi,
Roman Lesyk and
Alexandr Sklyarov

Sci. Pharm.2017, 85(4), 35;https://doi.org/10.3390/scipharm85040035

24 October 2017

Small intestinal injury is known to be one of the most commonly appearing pathologies, resulting in the use of medications such as: nonsteroidal anti-inflammatory drugs (NSAIDs), antitumor drugs and angiotensin-converting enzyme (ACE) inhibitors. The...

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Article

8 Citations

3,792 Views

16 Pages

Antimycobacterial Activities of N-Substituted-Glycinyl 1H-1,2,3-Triazolyl Oxazolidinones and Analytical Method Development and Validation for a Representative Compound

Naser F. Al-Tannak and
Oludotun A. Phillips

Sci. Pharm.2017, 85(4), 34;https://doi.org/10.3390/scipharm85040034

2 October 2017

Twelve N-substituted-glycinyl triazolyl oxazolidinone derivatives were screened for antimycobacterial activity against susceptible (Mycobacterium tuberculosis (Mtb) H37Rv) and resistant (isoniazid (INH)-resistant Mtb (SRI 1369), rifampin (RMP)-resist...

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