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Leishmanicidal Activity of Biogenic Fe3O4 Nanoparticles

School of Medicine, Bam University of Medical Sciences, Bam, Iran
Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
Department of Biotechnology, Shahid Bahonar University of Kerman, Kerman, Iran
Fac de Ciências e Tecnologia-FCT, Universidade Estadual Paulista-UNESP, Presidente Prudente-SP 19060-900, Brazil
Department of Radiology, Kerman University of Medical Sciences, Kerman, Iran
Authors to whom correspondence should be addressed.
Academic Editor: Gernot A. Eller
Sci. Pharm. 2017, 85(4), 36;
Received: 31 August 2017 / Revised: 6 November 2017 / Accepted: 7 November 2017 / Published: 20 November 2017
PDF [4186 KB, uploaded 20 November 2017]


Abstract: Due to the multiplicity of useful applications of metal oxide nanoparticles (ONPs) in medicine are growing exponentially, in this study, Fe3O4 (iron oxide) nanoparticles (IONPs) were biosynthesized using Rosemary to evaluate the leishmanicidal efficiency of green synthesized IONPs. This is the first report of the leishmanicidal efficiency of green synthesized IONPs against Leishmania major. The resulting biosynthesized IONPs were characterized by ultraviolet-visible spectroscopy (UV-Vis), X-ray diffraction (XRD), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FTIR). The leishmanicidal activity of IONPS was studied via 3-4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results showed the fabrication of the spherical shape of monodisperse IONPs with a size 4 ± 2 nm. The UV-visible spectrophotometer absorption peak was at 334 nm. The leishmanicidal activity of biogenic iron oxide nanoparticles against Leishmania major (promastigote) was also studied. The IC50 of IONPs was 350 µg/mL. In this report, IONPs were synthesized via a green method. IONPs are mainly spherical and homogeneous, with an average size of about 4 nm, and were synthesized here using an eco-friendly, simple, and inexpensive method. View Full-Text
Keywords: biosynthesis; iron oxide nanoparticles; IONPs; leishmanicidal biosynthesis; iron oxide nanoparticles; IONPs; leishmanicidal

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Khatami, M.; Alijani, H.; Sharifi, I.; Sharifi, F.; Pourseyedi, S.; Kharazi, S.; Lima Nobre, M.A.; Khatami, M. Leishmanicidal Activity of Biogenic Fe3O4 Nanoparticles. Sci. Pharm. 2017, 85, 36.

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