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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2009, 77(Short Lectures (SL)), 178; (registering DOI)

An Acoustically-Driven Biochip: Particle-Cell In-teractions Under Physiological Flow Conditions

Dept. of Pharm. Technology& Biopharmaceutics, University of Vienna, Althanstr. 14, 1090 Vienna, Austria
Biological Physics Group, University Augsburg, Universitätsstr. 1, 86159, Augsburg, Germany
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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Introduction: The interaction of particulate drug carriers with cells has generally been assessed in stationary microplate assays. These setups fail to reflect the flow conditions in vivo which generate substantial hydrodynamic drag forces [1]. In order to address this shortcoming, a microfluidic biochip with the capability of imitating a wide range of shear rates and pulsation modes has been developed. This device, which is based on an incorporated surface acoustic wave pump, was used to study the interaction of targeted microparticles with epithelial cells under flow conditions.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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FILLAFER, C.; RATZINGER, G.; NEUMANN, J.; DISSAUER, S.; WIRTH, M.; GABOR, F.; SCHNEIDER, M. An Acoustically-Driven Biochip: Particle-Cell In-teractions Under Physiological Flow Conditions. Sci. Pharm. 2009, 77, 178.

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