Triflate-mediated Synthesis of 3-(4-Methoxyquinazolin-2-yl)- quinazolin-2,4-(1H,3H)-dione and its Antimicrobial Activity.

Usifoh C. O.; Ukoh G. C.

doi:10.3797/scipharm.aut-02-14

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Article

23 April 2002

Triflate-mediated Synthesis of 3-(4-Methoxyquinazolin-2-yl)- quinazolin-2,4-(1H,3H)-dione and its Antimicrobial Activity.

and

Departments of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria

Pharmaceutical Microbiology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria

Author to whom correspondence should be addressed.

Sci. Pharm.2002, 70(2), 123-128;https://doi.org/10.3797/scipharm.aut-02-14

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Abstract

The synthesis of a novel quinazolinone was accomplished by the reaction of quinazolin- 2,4-(1H,3H)-dione with trifluoromethanesulfonic anhydride in triethylamine. The antimicrobial activity was determined against eight microorganisms. The organisms were all susceptible to 3-(4-methoxyquinazolin-2-yl)-quinazolin-2,4-(1H,3H)-dione 3 at the concentrations used. The gram positive organisms showed more susceptibility than the gram negative ones.

Keywords:

Quinazolinoe, Triflate, Antimicrobial activity

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