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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

Table of Contents

Sci. Pharm., Volume 68, Issue 4 (December 2000) – 10 articles , Pages 333-438

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Open AccessArticle
Zur Elementbestimmung in Solanaceen
Sci. Pharm. 2000, 68(4), 435-438; https://doi.org/10.3797/scipharm.aut-00-40 - 18 Dec 2000
Cited by 2 | Viewed by 393
Abstract
The Contents of Al, Ba, Cr, Cu, Sr, and Zn in Atropa belladonna, Datura stramonium, and Hyoscyamus niger are measured by ICP-AES. Enrichment of these elements in the leaves is observed. Full article
Open AccessArticle
Buchariate: An Aromatic Ester from Salvia bucharica
Sci. Pharm. 2000, 68(4), 429-433; https://doi.org/10.3797/scipharm.aut-00-39 - 12 Dec 2000
Cited by 10 | Viewed by 420
Abstract
Salvia bucharica belonging to the family Lamiaceae (Labiatae), afforded a new aromatic ester named buchariate [1-(p-hydroxybenzoyloxy)-3-oxo-octane (1)] along with twelve known constituents for the first time from our investigated source. The structures of all the isolated constituents were determined [...] Read more.
Salvia bucharica belonging to the family Lamiaceae (Labiatae), afforded a new aromatic ester named buchariate [1-(p-hydroxybenzoyloxy)-3-oxo-octane (1)] along with twelve known constituents for the first time from our investigated source. The structures of all the isolated constituents were determined through spectroscopic techniques and comparison with literature values. The structure of new constituent (1) was elucidated through extensive 2-D NMR experiments. Full article
Open AccessArticle
Bufadienolides from Drimia robusta BAK
Sci. Pharm. 2000, 68(4), 421-427; https://doi.org/10.3797/scipharm.aut-00-38 - 01 Dec 2000
Cited by 2 | Viewed by 388
Abstract
From bulbs of Drimia robusta 7 bufadienolides were isolated, 3 of them new natural compounds. Structure elucidation was performed by comparison with authentic substances or by means of 1H-, 13C-NMR-spectroscopy and FAB-MS. The substances were identified as scilliroside (1), [...] Read more.
From bulbs of Drimia robusta 7 bufadienolides were isolated, 3 of them new natural compounds. Structure elucidation was performed by comparison with authentic substances or by means of 1H-, 13C-NMR-spectroscopy and FAB-MS. The substances were identified as scilliroside (1), 12ß-hydroxyscillirosidin (2), 12ß-hydroxyscilliroside (3), hellebrigenin-3-0-ß-glucoside (4), 16ß-hydroxyhellebrigenin (5), 16ß-hydroxyhellebrigenin-3-O-ß-glucoside (6) and 5ß,16ß-dihydroxybufalin-3-O-ß-glucoside (7). Full article
Open AccessArticle
SPECTROPHOTOMETRIC DETERMINATION OF SOME PHARMACEUTICAL COMPOUNDS USING 2,2-DIPHENYL-1-PICRYLHYDRAZYL
Sci. Pharm. 2000, 68(4), 403-419; https://doi.org/10.3797/scipharm.aut-00-37 - 24 Nov 2000
Cited by 3 | Viewed by 382
Abstract
A simple, rapid and sensitive spectrophotometric procedure for the assay of some drugs has been developed. The method is based on the reaction of the studied drugs with 2,2-diphenyl-1-picrylhydrazyl (DPPH). The latter is employed to abstract a hydrogen atom from the drugs thereby [...] Read more.
A simple, rapid and sensitive spectrophotometric procedure for the assay of some drugs has been developed. The method is based on the reaction of the studied drugs with 2,2-diphenyl-1-picrylhydrazyl (DPPH). The latter is employed to abstract a hydrogen atom from the drugs thereby promoting a process of radical coupling. This results in a reduction of the violet color of DPPH with the formation of the yellow colored 2,2-diphenyl-1-picrylhydrazine (DPPH2). The decrease in the intensity of the violet color is used to measure the concentration of the drugs. All measurements are made at λ= 520 nm on methanolic solutions of the reagent and drugs. Beer's law is obeyed in the ranges of 5-30 µg/ml (for aceclofenac, diclofenac sodium and thiaprofenic acid), 2-15 µg/ml (for tenoxicam, furosemide and lansoprazole) and 2-12 µg/ml (for benoxinate hydrochloride and ritodrine). The validity of the method was tested by carrying out standard addition procedure analyzing the studied drugs in pure form as well as in their pharmaceutical preparations without interference from common additives. Results of the proposed methods are in good agreement with those of the official or reported methods. Full article
Open AccessArticle
Synthesis of Thienopyridines and Isoquinolines from 6-Amino-1,2-dihydro-4-methyl-2-thioxopyridine-3,5-dicarbonitrile and of Phthalazines from Thieno[3,4-c]pyridazine
Sci. Pharm. 2000, 68(4), 389-401; https://doi.org/10.3797/scipharm.aut-00-36 - 05 Nov 2000
Cited by 5 | Viewed by 371
Abstract
Thienopyridine 1 and thienopyridazine 13 have been readily reacted with electron-poor olefins to give isoquinolines and phthalazines, respectively. Some of the obtained compounds were tested for their antimicrobial activity. Full article
Open AccessArticle
Thermoregulatory and In-vivo Anti-inflammatory Effects of Vigabatrin In Rat and Mice
Sci. Pharm. 2000, 68(4), 379-388; https://doi.org/10.3797/scipharm.aut-00-35 - 01 Nov 2000
Cited by 3 | Viewed by 389
Abstract
Effects of acute administration of vigabatrin (VGB) that has significant GABA-mimetic properties were studied for its antiinflammatory, antigranuloma effects in rats and thermoregulatory actions in mice. Treatment of rats with VGB (125, 250 and 500 mg/kg, i.p doses) caused a significant and persistent [...] Read more.
Effects of acute administration of vigabatrin (VGB) that has significant GABA-mimetic properties were studied for its antiinflammatory, antigranuloma effects in rats and thermoregulatory actions in mice. Treatment of rats with VGB (125, 250 and 500 mg/kg, i.p doses) caused a significant and persistent inhibition in the carrageenan induced paw edema. Inhibitory effect at high dose (500 mg/kg, which was about 10-fold of the maximal effective dose 50 mg/kg in humans) was 40-, 41- and 39% of the control at 2-, 3- and 4 hours afier the treatment. In cotton-pellet-granuloma study, only the high dose was significantly (P<0.05) effective and inhibition in granuloma was 17 and 28% of the control at 250 and 500 mg/kg doses, respectively. In another model, leukocyte migration to the inflamed peritoneal cavity was used as a parameter in rats. In this model, VGB (500 mg/kg, i.p) induced a significant (P<0.05) reduction in leukocyte migration to the inflamed peritoneal cavity when administered 30 min before carrageenan. This was comparable to indomethacin (10 mg/kg) that also caused a significant (P<0.05) reduction in leukocyte migration. The inhibition in the leukocyte migration was 66 and 61% with VGB and indomethacin, respectively. In thermoregulation studies, the rectal temperature of normothermic mice declined dose dependently. In another part of this study all the doses of VGB induced a significant reduction in body temperature at 45 min following drug administration in yeast-induced hyperpyrexic mice. The hypothermic response diminished after 90 min, 3 hours and 6 hours of treatment at 125, 250 and 500 mg/kg doses respectively and none of the dose showed any change in rectal temperature at 24-hour study point. The results of the present study indicate that vigabatrin has the potential to induce anti-edema, antigranuloma and leukocyte anti-migratory effects in inflamed peritoneal cavity and reduce the rectal temperature in normothermic as well as hyperthermia-induced mice with acute regimen. These effects are thought to be the result of GABA accumulation, its interaction with PG biosynthesis and other neuromediators. Full article
Open AccessArticle
Synthesis and Antitumour activity of some aryl semicarbazones
Sci. Pharm. 2000, 68(4), 369-377; https://doi.org/10.3797/scipharm.aut-00-34 - 16 Oct 2000
Cited by 6 | Viewed by 380
Abstract
Various 4-substituted phenyl semicarbazone derivatives were synthesized and evaluated in vitro by NCI in the 3-cell line, one dose primary anticancer assay. Three compounds showed significant activity against breast MCF7 cell line and were further evaluated for potential anticancer activity in an in [...] Read more.
Various 4-substituted phenyl semicarbazone derivatives were synthesized and evaluated in vitro by NCI in the 3-cell line, one dose primary anticancer assay. Three compounds showed significant activity against breast MCF7 cell line and were further evaluated for potential anticancer activity in an in vitro human disease-oriented tumour cell line screening panel that consisted of 60 human tumour cell lines arranged in nine subpanels, representing diverse histologies. Leukemia, colon, ovarian and breast cancer cell lines were relatively more sensitive to these compounds than the other cell lines. The 4-carboxy substituted p-nitrobenzylidene phenyl semicarbazone (1c) emerged as the most active compound with average GI50 value (the molar drug concentration required for the 50% growth inhibition) of 28.6µM. This compound showed greater activity than methotrexate against NCI-H226(Lung), BT-549 and T-47D(Breast) cancer cell lines. Full article
Open AccessArticle
Spectrophotometric and Conductometric Study of the Complexation of Ranitidine to Fez+, Fe3+, Al*, Mg*+, Cu", Ni2+ and PtP+ Metal Ions: Pharmaceutical Implications
Sci. Pharm. 2000, 68(4), 357-367; https://doi.org/10.3797/scipharm.aut-00-33 - 12 Oct 2000
Cited by 1 | Viewed by 380
Abstract
Complexation properties of ranitidine (Ran) with Fe2+, Fe3+, A13+, Mg2+, Cu2+, Ni2+ and Pb2+ were studied using UV/V|S spectroscopy and conductometric titrations respectively. Ranitidine was found to form 1:1 complexes in [...] Read more.
Complexation properties of ranitidine (Ran) with Fe2+, Fe3+, A13+, Mg2+, Cu2+, Ni2+ and Pb2+ were studied using UV/V|S spectroscopy and conductometric titrations respectively. Ranitidine was found to form 1:1 complexes in methanol or aqueous buffer (pH 6.5) with all cations except magnesium. In case of Fe3+ complexes of the formula [(Fe3+)2Ran] were evident. Full article
Open AccessArticle
Atomic Absorption Spectrometry of Acidic Pharmaceutical Constituents by Precipitation Using Co (II), Cd (II) and Mn (II)
Sci. Pharm. 2000, 68(4), 343-355; https://doi.org/10.3797/scipharm.aut-00-32 - 11 Oct 2000
Cited by 3 | Viewed by 393
Abstract
Simple and accurate methods are described for the quantitative determination of flufenamic acid, mefenamic acid and tranexamic acid utilizing precipitation reactions with cobalt, cadmium and manganese. The acidic drugs were precipitated from their neutral alcoholic solutions with cobalt sulphate, cadmium nitrate or manganese [...] Read more.
Simple and accurate methods are described for the quantitative determination of flufenamic acid, mefenamic acid and tranexamic acid utilizing precipitation reactions with cobalt, cadmium and manganese. The acidic drugs were precipitated from their neutral alcoholic solutions with cobalt sulphate, cadmium nitrate or manganese chloride standard solutions followed by direct determination of the ions in the precipitate or indirect determination of the ions in the filtrate by atomic absorption spectroscopy. The optimum conditions for precipitation were carefully studied. The molar ratio of the reactants was ascertained. Statistical analysis of the results compared to the results of the official methods revealed equal precision and accuracy. The suggested procedures were applied for determining flufenamic acid, mefenamic acid and tranexamic acid in pharmaceutical preperations as well and proved validity. Full article
Open AccessArticle
SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NEW SULPHONAMIDES OF PYRIMIDINE
Sci. Pharm. 2000, 68(4), 333-341; https://doi.org/10.3797/scipharm.aut-00-31 - 01 Oct 2000
Cited by 11 | Viewed by 377
Abstract
The paper presents the synthesis of 5-substituted pyrimidine sulphonamides as well as the results of studies on the antibacterial and antifungal activity of obtained derivatives. Full article
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