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Article

Synthesis and Antitumour activity of some aryl semicarbazones

by 1,*, 1, 2, 2 and 2
1
Department of Pharrnaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221005, (INDIA)
2
Division of CancerTreatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, (USA)
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2000, 68(4), 369-377; https://doi.org/10.3797/scipharm.aut-00-34
Received: 3 May 2000 / Revised: 28 August 2000 / Accepted: 28 August 2000 / Published: 16 October 2000

Abstract

Various 4-substituted phenyl semicarbazone derivatives were synthesized and evaluated in vitro by NCI in the 3-cell line, one dose primary anticancer assay. Three compounds showed significant activity against breast MCF7 cell line and were further evaluated for potential anticancer activity in an in vitro human disease-oriented tumour cell line screening panel that consisted of 60 human tumour cell lines arranged in nine subpanels, representing diverse histologies. Leukemia, colon, ovarian and breast cancer cell lines were relatively more sensitive to these compounds than the other cell lines. The 4-carboxy substituted p-nitrobenzylidene phenyl semicarbazone (1c) emerged as the most active compound with average GI50 value (the molar drug concentration required for the 50% growth inhibition) of 28.6µM. This compound showed greater activity than methotrexate against NCI-H226(Lung), BT-549 and T-47D(Breast) cancer cell lines.
Keywords: Aryl semicarbazones; Antitumour; Methotrexate Aryl semicarbazones; Antitumour; Methotrexate

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MDPI and ACS Style

Pandeya, S.N.; Yogeeswari, P.; Sausville, E.A.; Mauger, A.B.; Narayanan, V.L. Synthesis and Antitumour activity of some aryl semicarbazones. Sci. Pharm. 2000, 68, 369-377. https://doi.org/10.3797/scipharm.aut-00-34

AMA Style

Pandeya SN, Yogeeswari P, Sausville EA, Mauger AB, Narayanan VL. Synthesis and Antitumour activity of some aryl semicarbazones. Scientia Pharmaceutica. 2000; 68(4):369-377. https://doi.org/10.3797/scipharm.aut-00-34

Chicago/Turabian Style

Pandeya, S.N., P. Yogeeswari, E.A. Sausville, A.B. Mauger, and V.L. Narayanan. 2000. "Synthesis and Antitumour activity of some aryl semicarbazones" Scientia Pharmaceutica 68, no. 4: 369-377. https://doi.org/10.3797/scipharm.aut-00-34

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