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Open AccessArticle

Atomic Absorption Spectrometry of Acidic Pharmaceutical Constituents by Precipitation Using Co (II), Cd (II) and Mn (II)

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Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt
2
Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig , Egypt
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2000, 68(4), 343-355; https://doi.org/10.3797/scipharm.aut-00-32
Received: 20 June 2000 / Revised: 28 August 2000 / Accepted: 28 August 2000 / Published: 11 October 2000
Simple and accurate methods are described for the quantitative determination of flufenamic acid, mefenamic acid and tranexamic acid utilizing precipitation reactions with cobalt, cadmium and manganese. The acidic drugs were precipitated from their neutral alcoholic solutions with cobalt sulphate, cadmium nitrate or manganese chloride standard solutions followed by direct determination of the ions in the precipitate or indirect determination of the ions in the filtrate by atomic absorption spectroscopy. The optimum conditions for precipitation were carefully studied. The molar ratio of the reactants was ascertained. Statistical analysis of the results compared to the results of the official methods revealed equal precision and accuracy. The suggested procedures were applied for determining flufenamic acid, mefenamic acid and tranexamic acid in pharmaceutical preperations as well and proved validity.
Keywords: Cobalt; Cadmiun; Manganese; Flufenamic acid; Mefenamic acid; Tranexamic acid; Atomic Absorption Spectrophotometry Cobalt; Cadmiun; Manganese; Flufenamic acid; Mefenamic acid; Tranexamic acid; Atomic Absorption Spectrophotometry
MDPI and ACS Style

Salem, H.; El-Maamli, M.; Shalaby, A. Atomic Absorption Spectrometry of Acidic Pharmaceutical Constituents by Precipitation Using Co (II), Cd (II) and Mn (II). Sci. Pharm. 2000, 68, 343-355.

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